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02 Sep 2018 - 05 Sep 2018


Image: Gene therapy treated airway stem cells (Photo courtesy of Dr. Nigel Farrow, University of Adelaide).

Preconditioning Enhances Stem Cell Transplantation in CF Model

Disruption of the epithelial cell layer using the agent polidocanol was found to facilitate effective transplantation of cultured stem cells into nasal airways in a mouse model of cystic fibrosis. More...
15 Aug 2018
Image: Red blood cells can safely transport nanoscale drug carriers to chosen organs by targeted placement of intravascular catheters (Photo courtesy of the University of Pennsylvania).

RBC Transporters Used for Targeting Nanoparticle Drug Carriers

A novel, patent pending nanoparticle drug delivery system uses red blood cells to transport drug carriers directly to selected target organs with minimal exposure to other areas of the body. More...
14 Aug 2018
Image: A representation of the molecular structure of PDHX protein (Photo courtesy of Wikimedia Commons).

Cancer Growth Promoted by an Oncogenic MicroRNA

Cancer researchers have discovered a critical molecular mechanism by which a specific microRNA promotes breast cancer growth through suppression of production of the enzyme PDHX (pyruvate dehydrogenase complex component X). More...
02 Aug 2018
Image: A micrograph of a teratoma showing tissue from all three germ layers: mesoderm (immature cartilage - left-upper), endoderm (gastrointestinal glands - center-bottom) and ectoderm (epidermis - right) (Photo courtesy of Wikimedia Commons).

Teratomas Offer Source for Rebuilding Damaged Tissues

Muscle stem cells, which were derived from benign teratoma tumors, were found to demonstrate exceptional potential as starting material for rebuilding and maintaining damaged muscle tissues. More...
19 Jul 2018
Image: This artist\'s concept shows two nanoparticles coming into the brain (at top) while a pair of scissors cuts at bottom right. Use of gene editing to cut DNA at a precise location reduced autism symptoms in mice with fragile X syndrome (Photo courtesy of the University of California, Berkeley).

CRISPR/Cas9 Corrects Symptoms of Fragile X Syndrome in Model

In order to correct fragile X syndrome in a mouse model, a team of neurological disease researchers used gold nanoparticles rather than viruses to deliver the CRISP\Cas9 gene-editing tool to cells in striatum, a brain region associated with formation of habits. More...
06 Jul 2018
Image: Structure of the CFTR (cystic fibrosis transmembrane conductance regulator) protein. Mutations of the CFTR gene affecting chloride ion channel function lead to dysregulation of epithelial fluid transport in the lung, pancreas, and other organs, resulting in cystic fibrosis (Photo courtesy of Wikimedia Commons).

RNA-Based Gene Therapy Developed for Cystic Fibrosis

A potential gene therapy approach for treating cystic fibrosis utilizes lipid nanoparticle-delivered chemically modified mRNA. More...
05 Jul 2018
Image: Immune cells that ingested spider silk nanoparticles (in green). The endosomes – the part of the cell in which the nanoparticles release the vaccine – appear in blue (Photo courtesy of Bourquin Laboratory, University of Geneva).

Spider Silk Microparticle System Engineered for Anticancer Drugs

Engineered spider silk microparticles underlie a novel transport system for the delivery of immunotherapeutic drugs to critical stimulatory sites in the immune system. More...
25 Jun 2018

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