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Therapeutics

Image: Zika virus (green) preferentially targets the stem cells (red) in a human glioblastoma (Photo courtesy of Zhu et al., 2017).

Oncolytic Therapy Cures Glioblastoma in Model

Results of experiments conducted using a mouse glioblastoma model suggest that treatment with Zika virus could be used to treat this aggressive and usual fatal disease. More...
19 Sep 2017
Image: A diagram of a scaffold loaded with CAR T-cells and “microspheres” containing nutrients to help the cells multiply and then leave the scaffold to go attack cancer cells (Photo courtesy of the Fred Hutchinson Cancer Research Center).

Nanoparticle Reagent Simplifies Gene Expression Programming

Novel nanoparticle carriers were used to deliver mRNA directly to specific cell types (T-cells of the immune system and blood stem cells) in order to induce short-term changes in gene expression that could be harnessed to treat diseases ranging from cancer to diabetes. More...
13 Sep 2017
Image: A ribbon model of the beta-2 adrenergic receptor (Photo courtesy of Wikimedia Commons).

Depressing Stress Signaling Increases Immune Activity

Cancer researchers evaluating the immune status of the tumor microenvironment found that CD8+ T-cell frequency and functional orientation were regulated by beta-2-adrenergic receptor (beta-AR) signaling and suggested using clinically available beta-blockers in patients to improve responses to immunotherapy. More...
12 Sep 2017
Image: A molecular ribbon structure of prostate-specific membrane antigen (PSMA) (Photo courtesy of Wikimedia Commons).

Immunotherapy Slows Tumor Growth in Prostate Cancer Model

Cancer researchers have developed a novel immunotherapy technique based on synthetic DNA plasmids that successfully controlled tumor growth and prolonged survival in a mouse prostate cancer model. More...
01 Sep 2017
Image: A scanning electron micrograph (SEM) of a gold nanostar. The nanostar\'s size caused it to accumulate within tumors, where researchers used infrared light to heat it and destroy cancerous growths (Photo courtesy of Dr. Tuan Vo-Dinh, Duke University).

Combined Approach Cures Bladder Cancer in Model

A novel anticancer "photothermal immunotherapy" technique that used lasers and gold nanostars to heat up and destroy tumors in combination with an immunotherapeutic drug cured and immunized mice against bladder cancer in a small proof-of-concept study. More...
28 Aug 2017
Image: A new study advocates for the use of cardiac stem cells obtained from young hearts in reversing the process of aging in the human heart (Photo courtesy of Shutterstock).

Stem Cell Therapy Restores Youthful Heart Performance

Cardiac disease researchers have demonstrated in a rat model that injections of cardiosphere-derived cells from young rats could rejuvenate the hearts of aged animals. More...
24 Aug 2017
Image: Photomicrographs of muscle cells from a patient with myotonic dystrophy type I, untreated (left) and treated with the RNA-targeting Cas9 system (right). The MBNL1 protein is in green, repetitive RNA in red and the cell\'s nucleus in blue (Photo courtesy of the University of California, San Diego).

Progress Reported in Development of Gene Editing Tool

Progress has been reported in the effort to develop a CRISPR/Cas9 gene editing tool to be used for modifying RNA rather than the usual target DNA. More...
21 Aug 2017
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BioResearch Therapeutics channel deals with all aspects of therapies beyond the five-year horizon.
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