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Therapeutics

Image: An illustration of TRAFFIC (Thread-Reinforced Alginate Fiber for Islets enCapsulation), a novel removable implant device for control of type I diabetes (Photo courtesy of Cornell University).

Removable Device Developed for Treatment of Type I Diabetes

A team of biomedical engineers has devised a novel technique for implantation and removal of living pancreatic beta cells in order to control insulin levels in patients with type I diabetes. More...
18 Jan 2018
Image: Skeletal muscle cells isolated using the ERBB3 and NGFR surface markers (right) restore human dystrophin (green) after transplantation significantly greater than previous methods (left) (Photo courtesy of the University of California, Los Angeles and Nature Cell Biology).

Combined Treatments Cure Muscular Dystrophy in Model

A new approach for generating functional muscle tissue from induced human pluripotent stem cells enabled replacement of muscle loss in a mouse model of Duchenne muscular dystrophy (DMD). More...
03 Jan 2018
Image: An adeno-associated virus (AAV) was used to transport genes for CRISPR/Cas9 into motor neurons to delay onset of symptoms of ALS in mice (Photo courtesy of Dr. David Schaffer, University of California, Berkeley).

CRISPR/Cas9 Treatment Eases Symptoms in ALS Model

Neurodegenerative disease researchers treated a mouse model of amyotrophic lateral sclerosis with a modified adeno-associated virus that delivered the CRISPR/Cas9 gene-editing tool to the animals' neurons, where it disabled a malfunctioning gene. More...
01 Jan 2018
Image: Three T-cells surround a cancer cell. New drugs, such as immune checkpoint inhibitors, can help the immune system attack cancer, but the drugs’ effectiveness depends on the patient’s genetic makeup (Photo courtesy of the U.S. National Institutes of Health).

Immune Checkpoint Inhibitor Effectiveness Dependent on HLA Diversity

Findings reported in a recently published paper suggested that an individual’s own genes controlled his or her response to immunotherapy drugs known as immune checkpoint inhibitors. More...
25 Dec 2017
Image: An advanced in vivo Cas9-based epigenetic gene activation system enhances skeletal muscle mass (top) and fiber size growth (bottom) in a treated mouse (right) compared with an independent control (left). The fluorescent microscopy images at bottom show purple staining of the laminin glycoprotein in tibialis anterior muscle fibers (Photo courtesy of the Salk Institute for Biological Research).

Novel Gene Therapy Based on Modified Version of CRISPR/Cas9 Tool

A modified form of the CRISPR/Cas9 gene-editing tool does not cause "double-strand breaks" (DSBs) in the DNA, yet it retains the ability to target and activate specific sites in the genome. More...
21 Dec 2017
Image: A photomicrograph of green-stained, proliferating cardiomyocytes in a mouse heart after gel injection (Photo courtesy of the University of Pennsylvania).

MicroRNA Treatment Prompts Cardiomyocyte Proliferation

Working with a variety of mouse models, heart diseases researchers showed that a hydrogel delivery system could release a specific microRNA at the site of injury following a myocardial infarction where it induced cardiomyocyte proliferation and tissue regeneration. More...
11 Dec 2017
Image: Melanin protein (light refracting granular material at the center of the photomicrograph) in a pigmented melanoma (Photo courtesy of Wikimedia Commons).

Light-Enhanced Microneedle Vaccine Prevents Melanoma Development

A novel immunotherapeutic vaccine prevented the development of skin cancer in a mouse model by exploiting the ability of the protein melanin to transform light energy into heat. More...
20 Nov 2017
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BioResearch Therapeutics channel deals with all aspects of therapies beyond the five-year horizon.
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