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Image: A photomicrograph of green-stained, proliferating cardiomyocytes in a mouse heart after gel injection (Photo courtesy of the University of Pennsylvania).

MicroRNA Treatment Prompts Cardiomyocyte Proliferation

Working with a variety of mouse models, heart diseases researchers showed that a hydrogel delivery system could release a specific microRNA at the site of injury following a myocardial infarction where it induced cardiomyocyte proliferation and tissue regeneration. More...
11 Dec 2017
Image: Melanin protein (light refracting granular material at the center of the photomicrograph) in a pigmented melanoma (Photo courtesy of Wikimedia Commons).

Light-Enhanced Microneedle Vaccine Prevents Melanoma Development

A novel immunotherapeutic vaccine prevented the development of skin cancer in a mouse model by exploiting the ability of the protein melanin to transform light energy into heat. More...
20 Nov 2017
Image: An artist\'s rendition of a fluorescence microscope image of the artificial beta cells (Photo courtesy of Gu Laboratory, University of North Carolina).

Novel Approach for Treating Diabetes Based on Artificial Beta Cells

A possible long-term approach for treating diabetes could be based on a novel type of artificial pancreatic beta cells capable of releasing insulin in response to elevated levels of glucose. More...
14 Nov 2017
Image: In this reconstituted schematic, hematopoietic stem cells (HSC) transplanted in a mouse model of Friedreich\'s ataxia differentiate into microglial cells (red) and transfer mitochondrial protein (green) to neurons (blue), preventing neurodegeneration (Photo courtesy of Dr. Stephanie Cherqui, University of California, San Diego).

Stem Cell Therapy Cures Friedreich's Ataxia in Mouse Model

Stem cell therapy was used to cure Friedreich's ataxia in a mouse model of the fatal degenerative disease. More...
09 Nov 2017
Image: Researchers have found that magnetic nanoparticles could be appropriate for use in self-regulating hyperthermia therapeutics (Photo courtesy of iStock).

Novel Ferrite Nanoparticles for Hyperthermic Cancer Therapeutics

A novel type of nontoxic magnetic nanoparticles shows potential for treating malignant tumor cells through controlled hyperthermia. More...
08 Nov 2017
Image: A photomicrograph of a liver biopsy from a patient with alpha-1 antitrypsin deficiency. The PAS with diastase stain shows the diastase-resistant pink globules that are characteristic of this disease (Photo courtesy of Wikimedia Commons).

Diseased Liver Model Facilitates Search for AAT Deficiency Cure

Researchers have developed a new humanized liver mouse model with the mutation that causes alpha-1 antitrypsin deficiency in order to determine whether it is possible to cure the disease by repopulating the defective liver with gene edited healthy cells. More...
02 Nov 2017
Image: Researchers have found MS can be inhibited or reversed using a novel gene therapy technique that stops the disease’s immune response in mouse models (Photo courtesy of the University of Florida Health).

Gene Therapy Targets Liver in Mouse MS Study

Results of studies carried out on a mouse model of multiple sclerosis (MS) demonstrated the potential of a novel potent and long-lasting gene immunotherapy approach for preventing and treating the disease. More...
02 Oct 2017
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