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Image: A scanning electron micrograph (SEM) of engineered T-cells lacking coronin 1 (Photo courtesy of the University of Basel).

Novel Method Prevents Rejection of Transplanted Organs

A team of Swiss researchers reported finding a method that prevents rejection of transplanted organs without lessening the immune system's ability to fight off infection by pathogenic microorganisms. More...
28 Jan 2019
Image: A diagram of how regulatory T-cells suppress effector T-cells and dendritic cells (Photo courtesy of Wikimedia Commons).

Gene Therapy Cures Severe Autoimmune Disorder in Model

An often fatal autoimmune disorder was cured in mice by using a lentiviral vector to insert a working copy of the defective FOXP3 (Forkhead box P3, also known as scurfin) gene into blood stem cells. More...
24 Jan 2019
Image: A representation of the movement of the flower-like particle as it makes its way to deliver therapeutic genes (Photo courtesy of Washington State University).

Fluorinated Nanoparticles Facilitate Drug Transfer to Cellular Cytosol

In a proof-of-principle study, novel "nanoflower" drug transporters were used to successfully deliver model drug analogues to cells growing in culture. More...
22 Jan 2019
Image: A molecular model of the Melanocortin 4 receptor (Mc4r) protein (Photo courtesy of Wikimedia Commons).

Gene Editing Prevents Mice from Developing Hereditary Obesity

A modified version of the CRISPR/Cas9 genome-editing tool was used to correct a mutated gene in mice, which prevented the animals from becoming obese. More...
27 Dec 2018
Image: Two megakaryoctes (see arrows) are visible in this slide of bone marrow (Photo courtesy of Wikimedia Commons).

Gene Therapy Treatment Uses Microparticles to Deliver DNA or RNA

A novel gene therapy approach for correcting hereditary blood disorders is based on the use of megakaryocytic microparticles (MkMPs) to deliver plasmid DNAs and small RNAs to hematopoietic stem and progenitor cells (HSPCs). More...
18 Dec 2018
Image: Toxic amyloid plaques (red) and tau tangles (brown) form on the brain of a mouse modeled to have Alzheimer\'s disease. This study shows that a DNA vaccine reduces both amyloid and tau in the mouse AD model, with no adverse immune responses (Photo courtesy of the University of Texas Southwestern Medical Center).

Novel DNA Vaccine Prevents AD in Mouse Model

A team of Alzheimer's disease (AD) researchers has shown that a DNA vaccine directed at the toxic Abeta42 peptide protected the animals comprising a mouse (AD) model from both amyloid plaques and pathogenic tau tangles. More...
04 Dec 2018
Image: A scanning electron micrograph (SEM) of a human T-cell (Photo courtesy of the U.S. National Institutes of Health).

Technology Evaluated for T-cell Receptor Identification and Cloning

A team of cancer researchers developed a tracking and screening system that accurately identifies T-cell receptors from individual tumors within just a few days. More...
21 Nov 2018

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