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27 Jun 2018 - 29 Jun 2018
07 Jul 2018 - 11 Jul 2018
07 Jul 2018 - 12 Jul 2018


Image: A population of induced pluripotent stem cell-derived neurons in an allogenic, previously injured spinal cord of a pig at three-and-a-half months (Photo courtesy of the University of California, San Diego).

Neural Cells Repair Spinal Cord Damage without Triggering Rejection

Stem cell researchers working with a porcine model have demonstrated the potential for using neural precursor cells (NPCs) – derived from induced pluripotent stem cells (iPSCs) that had once been skin cells – to repair damage to the spinal cord. More...
24 May 2018
Image: Left two panels: Hepatocyte-like cells (HLCs) differentiated from the stem cells of patients with hemophilia B show very low levels of clotting factor IX, (FIX), shown in white. Right two panels: After treating these same cell lines with a gene correction tool, FIX increased to healthy levels (Photo courtesy of the Salk Institute).

Cell-based Gene Therapy Treatment Cures Hemophilia B in Model

A novel, cell-based gene therapy approach was used to cure hemophilia B in a mouse model of the disease. More...
17 May 2018
Image: Nanoparticles loaded with the dual immunotherapy platform (Photo courtesy of UNC Lineberger Comprehensive Cancer Center).

Nanoparticle Delivery Increases Effectiveness of Anti-Cancer Immunotherapy

A nanoparticle delivery system was used to transport antibody-based immunotherapeutic drugs in trials conducted in cancer cell in vitro cultures and in animal models. More...
10 May 2018
Image: Histological sections of liver from control mice treated with saline (left) and the CRISPR/Cas9 epigenetic repression system in which cholesterol levels were lowered (right) show generally normal and healthy tissue (Photo courtesy of Dr. Charles Gersbach, Duke University).

Model Demonstrates Potential for Long-Term Gene Silencing

An adeno-associated viral (AAV) vector was used to deliver a modified version of the CRISPR/Cas9 gene-editing tool to liver cells in a mouse model, which resulted in suppression of the serum enzyme Pcsk9 and reduction of cholesterol levels. More...
08 May 2018
Image: Recovery of the injured heart muscle after four weeks of treatment with extracellular vesicles. Immunostains: wheat germ agglutinin (red), troponin (green), and DAPI [(4\',6-diamidino-2-phenylindole)] (blue) (Photo courtesy of Dr. Gordana Vunjak-Novakovic, Columbia University School of Engineering and Applied Science).

Cardiomyocyte Extracellular Vesicles Repair Heart Damage in Model

Studies conducted with a rat myocardial infarction model demonstrated the benefits of treating damaged heart muscle with extracellular vesicles (EVs) secreted by cardiomyocytes. More...
02 May 2018
Image: Organoids created from the bladder cancers of patients mimic the characteristics of each patient\'s tumor and may be used in the future to identify the best treatment for each patient (Photo courtesy of Columbia University Medical Center).

Bladder Cancer Organoids May Lead to Treatment Breakthrough

Cancer researchers have established a "bio-bank" of patient-derived organoid lines that recapitulates the histopathological and molecular diversity of human bladder cancer. More...
19 Apr 2018
Image: Genetically modified astrocytes (red) line the lesion border in the injured spinal cord. A new mouse study showed that triggering a gene inside astrocytes activated the star-shaped cells and may improve the brain’s ability to heal from a range of debilitating conditions, from stroke to concussions and spine injuries (Photo courtesy of Dr. Meifan Amy Chen, University of Texas Southwestern Medical Center).

Critical Brain Cell Repair Gene Identified in Study

Repair of damaged brain cells depends on the process of astrogliosis, which has been shown to be regulated by the MAP3K13 (also known as leucine zipper-bearing kinase [LZK]) gene. More...
10 Apr 2018

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