We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.
Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Events

27 Jun 2018 - 29 Jun 2018
07 Jul 2018 - 11 Jul 2018
07 Jul 2018 - 12 Jul 2018

In Vitro System Developed for Studying Lung Fibrosis

By BiotechDaily International staff writers
Posted on 05 Jun 2018
Print article
Image: Collagen from a healthy engineered lung tissue (Photo courtesy of Dr. Ruogang Zhao).
Image: Collagen from a healthy engineered lung tissue (Photo courtesy of Dr. Ruogang Zhao).
A novel lung-on-a-chip device was tested in a proof-of-principle study with results suggesting that this technology could be used to evaluate a variety of potential treatments for lung fibrosis.

Fibrosis is a severe health problem characterized by progressive stiffening of tissues, which causes organ malfunction and failure. A major bottleneck in developing new anti-fibrosis therapies is the lack of in vitro models that recapitulate dynamic changes in tissue mechanics during fibrogenesis.

To help overcome the lack of in vitro model systems for fibrosis, investigators at the University at Buffalo (NY, USA) created membranous human lung microtissues to model key biomechanical events occurred during lung fibrogenesis.

The investigators used microlithography to print microscale pillars of silicon-based organic polymer onto flexible plastic chips. Lung tissue cultured on top of the pillars behaved like functional alveoli. Fibrosis was induced by introducing a protein that caused healthy lung cells to become diseased, leading to the contraction and stiffening of the lung tissue.

The investigators reported in the May 25, 2018, online edition of the journal Nature Communications that by demonstrating these capabilities they had provided proof-of-principle evidence for using this fibrotic tissue array for multi-parameter, phenotypic analysis of the therapeutic efficacy of two anti-fibrosis drugs recently approved by the [U.S.] Food and Drug Administration. The test system confirmed that treatment with either Pirfenidone or Nintedanib reduced tissue contractility and prevented tissue stiffening and decline in tissue compliance.

"Obviously it is not an entire lung, but the technology can mimic the damaging effects of lung fibrosis. Ultimately, it could change how we test new drugs, making the process quicker and less expensive," said senior author Dr. Ruogang Zhao, assistant professor of biomedical engineering at the University at Buffalo.

Related Links:
University at Buffalo


Print article

Channels

Business

view channel

Collaborative Agreement to Aid in Setting Guidelines for Evaluating Potential Ebola Therapy

Cooperation between an Israeli biopharmaceutical company and medical branches of the US government is designed to set ground rules for continued evaluation of an experimental therapy for Ebola virus disease. RedHill Biopharma Ltd. (Tel Aviv, Israel), a biopharmaceutical company primarily focused on development and c... Read more
Copyright © 2000-2018 Globetech Media. All rights reserved.