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02 Sep 2018 - 05 Sep 2018


Image: Gene therapy treated airway stem cells (Photo courtesy of Dr. Nigel Farrow, University of Adelaide).

Preconditioning Enhances Stem Cell Transplantation in CF Model

Disruption of the epithelial cell layer using the agent polidocanol was found to facilitate effective transplantation of cultured stem cells into nasal airways in a mouse model of cystic fibrosis. More...
15 Aug 2018
Image: Red blood cells can safely transport nanoscale drug carriers to chosen organs by targeted placement of intravascular catheters (Photo courtesy of the University of Pennsylvania).

RBC Transporters Used for Targeting Nanoparticle Drug Carriers

A novel, patent pending nanoparticle drug delivery system uses red blood cells to transport drug carriers directly to selected target organs with minimal exposure to other areas of the body. More...
14 Aug 2018
Image: An illustration showing the protein cas12a bound to a DNA helix (red and white) (Photo courtesy of T. Yamano and H. Nishimasu / James Rybarski).

CRISPR Variant Enables More Accurate Genome Editing

Results of a recent study suggested that inherent binding properties of the Cas12a enzyme make it a better choice for gene editing purposes than the currently used CRISPR/Cas9 combination. More...
13 Aug 2018
Image: The figure shows two views, frontal and lateral, of the image obtained by CT of the lungs of a mouse with fibrosis (grey areas) before and after receiving nano-therapy directed at senescent cells (Photo courtesy of Guillem Garaulet and Francisca Mulero, Institute for Research in Biomedicine).

Gel Encapsulation Transport System Targets Disease-Related Cells

A novel therapeutic approach uses drugs encapsulated within galacto‚Äźoligosaccharide gel capsules to target diseases that have accumulated a high percentage of senescent cells. More...
10 Aug 2018
Image: The effects of p53 in cancer-associated fibroblasts on cancer cell migration: Cancer cells (magenta) migrate in the direction of cancer-associated fibroblasts (yellow) that express a non-mutated p53 gene (left); this migration slows down (center) when the p53 in the fibroblasts is silenced; when substances released by the cancer-associated fibroblasts are added to the laboratory dish, the migration is restored (right) (Photo courtesy of the Weizmann Institute of Science).

Conditions in the Tumor Microenvironment Change Role of p53

Cancer researchers have found that changes occurring in the tumor microenvironment manipulate the activity of fibroblast p53 protein, causing it to promote rather than restrict cancer growth. More...
09 Aug 2018
Image: A transmission electron micrograph (TEM) of norovirus particles in feces (Photo courtesy of Wikimedia Commons).

Norovirus Binding Requires Attachment to Fucose Residues

Norovirus, the most common cause of gastroenteritis worldwide, depends on binding to fucose molecules in order to attach to and invade cells in the human digestive tract. More...
09 Aug 2018
Image: Microcultures of oligocortical spheroids (Photo courtesy of Case Western Reserve University School of Medicine).

Stem Cell-Based Cultures Used for Brain Disease Research

A team of neurological disease researchers used stem cell technology to culture mini-organoids comprising all the major cell types found in the human cerebral cortex - including oligodendrocytes - for brain structure/function research. More...
08 Aug 2018

BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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