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Genomics/Proteomics

Image: An illustration of a TOP2 DNA-protein cross-link (TOP2cc in magenta) bound to DNA (Photo courtesy of Dr. Scott Williams).

Enzyme Mechanism Corrects Cellular DNA Damage

Researchers have identified a mechanism used by cells to correct damage to their DNA caused by chemotherapeutic drugs and some antibiotics. More...
16 Oct 2017
Image: A model of a potent peptide that targets influenza virus hemagglutinin and mimics the functionality of a broadly neutralizing antibody (Photo courtesy of Rameshwar U. Kadam, Ian Wilson\'s Laboratory, The Scripps Research Institute).

Potential Peptide Drugs Block Influenza Virus Activity

A recent paper described the design and structural characterization of a class of potent peptide inhibitors specifically targeted to block the activity of influenza virus hemagglutinin. More...
12 Oct 2017
Image: Mice infected with the bacteria Yersinia pseudotuberculosis form granulomas - structures that confine pathogens. But those with a mutant form of the RIPK1 enzyme, rendering cells unable to undergo a particular form of cell death called apoptosis, do not. This RIPK1-induced apoptosis is thought to be a strategy that helps dying cells alert their neighbors that an infection is present (Photo courtesy of the University of Pennsylvania).

Mechanism Identified Protects Cells from Virulence Factors

A team of molecular microbiologists has identified the mechanism that allows some cells to survive invasion by pathogenic bacteria such as species of Yersinia, which cause a range of illness from plague to gastrointestinal disease in humans. More...
10 Oct 2017
Image: The Crystallographic structure of NR0B1 (rainbow colored) complexed with the nuclear receptor protein LRH-1 (Liver receptor homolog-1) (Photo courtesy of Wikimedia Commons).

Advanced Proteomics Strategy Identifies Promising Drug Target

Use of an advanced proteomics strategy led to the discovery of a protein in non-small-cell lung cancer (NSCLC) cells that could be targeted by low molecular weight drugs. More...
09 Oct 2017
Image: Zebrafish β-cells labeled using the newly developed Beta-bow system through the combinatorial expression of fluorescent proteins, allowing the developmental history of β-cells to be traced during islet growth (Photo courtesy of and Ninov Lab, TU Dresden).

Beta-cells Heterogeneity Uncovered by Tracing Developmental Origins

Heterogeneity among β-cells has recently become evident, and it is thought that this heterogeneity might play a role in the progression of diabetes. Researchers have developed a system that enables tracing of the developmental history of β-cells by genetic barcoding and multicolor imaging. In a study using the zebrafish model, they found that different histories of β-cells generate functional and proliferative heterogeneity during islet growth. More...
05 Oct 2017
Image: Tissue staining shows Group A Streptococcus soft tissue infection at the cellular level. (L-R) Uninfected mouse tissue and mouse tissue 48 hours after infection. The dense dots indicate immune system cells that swarmed in to attempt to control the infection. The densest purple staining toward the bottom is necrotic tissue surrounding bacteria (Photo courtesy of Joshua Leiberman, University of Maryland).

Two Critical Genes Identified for Soft Tissue Infections

A team of molecular microbiologists has identified two genes that are critical for infection of soft tissue and dissemination into the bloodstream by pathogenic Group A Streptococcus bacteria. More...
04 Oct 2017
Image: Four spherical S. aureus bacteria being enveloped and destroyed by human white blood cells (Photo courtesy of the U.S. National Institute of Allergy and Infectious Diseases).

Staphylococcus Aureus Avoids Inducing Immune Memory in Model

A team of medical microbiologists has identified the mechanism that prevents the body's immune system from developing an effective protective response to repeated Staphylococcus aureus infections. More...
03 Oct 2017
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BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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