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Genomics/Proteomics

Image: Circulating tumor DNA (ct or cfDNA) is found in serum and plasma fractions from blood. The mechanism of cfDNA release is unknown, though apoptosis, necrosis, and active secretion from tumor cells have been hypothesized (Photo courtesy of Wikimedia Commons).

Computer Program Confirms Relationship of cfDNA and Tumor DNA

Cancer researchers have developed an accurate, scalable approach for monitoring cell-free tumor DNA from blood samples. More...
16 Nov 2017
Image: An artist\'s rendition of a fluorescence microscope image of the artificial beta cells (Photo courtesy of Gu Laboratory, University of North Carolina).

Novel Approach for Treating Diabetes Based on Artificial Beta Cells

A possible long-term approach for treating diabetes could be based on a novel type of artificial pancreatic beta cells capable of releasing insulin in response to elevated levels of glucose. More...
14 Nov 2017
Image: A scanning electron micrograph (SEM) of the influenza virus (Photo courtesy of the CDC).

Gene Vaccine Protects Mice from Influenza Virus Strains

A team of molecular virologists protected mice from deadly infection caused by a range of influenza viruses by using a deactivated adenovirus vector to vaccinate them with a cocktail of centralized viral genes. More...
13 Nov 2017
Image: In this reconstituted schematic, hematopoietic stem cells (HSC) transplanted in a mouse model of Friedreich\'s ataxia differentiate into microglial cells (red) and transfer mitochondrial protein (green) to neurons (blue), preventing neurodegeneration (Photo courtesy of Dr. Stephanie Cherqui, University of California, San Diego).

Stem Cell Therapy Cures Friedreich's Ataxia in Mouse Model

Stem cell therapy was used to cure Friedreich's ataxia in a mouse model of the fatal degenerative disease. More...
09 Nov 2017
Image: A synthetic tissue releases therapeutic proteins (maroon/yellow) once triggered by metabolites (sandy brown). The metabolites contact with the double-stranded DNA (red/blue) to release the red triggering DNA. The triggering DNA activates the aptamer (cyan)-protein complex to release the protein (Photo courtesy of Xin Zou and Jinping Lai / Pennsylvania State University).

Hydrogel-Based Model System Mimics Cellular Signaling Processes

An artificial hydrogel-based model system responds to chemical signals by binding or releasing bound proteins in a manner similar to processes occurring in living cells. More...
07 Nov 2017
Image: A Cas13a molecule pictured with an RNA molecule (Photo courtesy of Lauren Solomon, Broad Communications).

CRISPR Tool Enables Genome Repair by Precise RNA Editing

The CRISPR/Cas9 gene-editing tool has been modified to act as a promising RNA editing platform with broad applicability for research, therapeutics, and biotechnology. More...
06 Nov 2017
Image: A photomicrograph of a liver biopsy from a patient with alpha-1 antitrypsin deficiency. The PAS with diastase stain shows the diastase-resistant pink globules that are characteristic of this disease (Photo courtesy of Wikimedia Commons).

Diseased Liver Model Facilitates Search for AAT Deficiency Cure

Researchers have developed a new humanized liver mouse model with the mutation that causes alpha-1 antitrypsin deficiency in order to determine whether it is possible to cure the disease by repopulating the defective liver with gene edited healthy cells. More...
02 Nov 2017
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BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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