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Genomics/Proteomics

Image: The structure of the NRAS protein (Photo courtesy of Wikimedia Commons).

Experimental Drug Blocks Development of Malignant Melanomas

A promising experimental drug may prevent growth and spread of malignant melanomas having a mutation in the NRAS gene. More...
14 Feb 2019
Image: A photomicrograph showing the CDX2 transcription factor localized to mitotic chromosomes (Photo courtesy of Dr. David Suter, Ecole Polytechnique Fédérale de Lausanne).

Interaction of Transcription Factors Can Predict DNA Binding

A team of Swiss stem cell researchers has demonstrated that by observing the binding of transcription factors to mitotic chromosomes it is possible to predict how they will bind non-specifically to DNA. More...
13 Feb 2019
Image: Part of the Myosin II structure. Atoms in the heavy chain are colored pink (on the left-hand side); atoms in the light chains are colored faded-orange and faded-yellow (also on the left-hand side) (Photo courtesy of Wikimedia Commons).

Melanoma Cells Secrete Factors to Promote Tumor Growth

A team of British researchers found that high Myosin II activity in invasive melanoma cells induced reprogramming of innate immune responses in the local microenvironment to support tumor growth. More...
12 Feb 2019
Image: The microvessel-on-a-chip used for angiogenesis research (Photo courtesy of Dr. Yukiko Matsunaga, Institute of Industrial Science, the University of Tokyo).

Three-Dimensional Growth Chamber Promotes Understanding of Angiogenesis

Collaboration between French and Japanese researchers resulted in the development of a three-dimensional "microvessel-on-a-chip" device for advancing the understanding of the processes that drive angiogenesis (production of new blood vessels). More...
11 Feb 2019
Image: A micrograph showing tangles of tau protein (green) in the brain cell of a person who had Alzheimer’s disease (Photo courtesy of Thomas Deerinck of the National Center for Microscopy and Imaging Research at the University of Califronia, San Diego School of Medicine).

Lowering Cholesteryl Ester Levels Reduces Tau Tangles

An excess of cholesteryl esters, the storage product for excess cholesterol within cells, was shown to induce tau protein in neurons to form abnormal aggregates called neurofibrillary tangles that are characteristic of Alzheimer's disease. More...
07 Feb 2019
Image: Researchers used CRISPR/Cas9 genome editing to control genetic inheritance in mammals for the first time (Photo courtesy of Cooper Laboratory, University of California, San Diego).

Genome Editing Used to Bias Genetic Inheritance in Mice

Genomics researchers have demonstrated the feasibility of using CRISPR/Cas9 gene editing to bias genetic inheritance in mice used for laboratory studies. More...
06 Feb 2019
Image: Modified human interleukin-27-alpha. Inspired by the murine interleukin-27-alpha, one amino acid has been exchanged, enabling the formation of a disulfide-bridge (marked in red) (Photo courtesy of Dr. M. Feige, Technical University of Munich).

Comparison of Human and Mouse Interleukins Reveals Link

A study comparing the structure and function of human and mouse interleukins revealed a close link between protein folding and immune regulation. More...
05 Feb 2019


BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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