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Genomics/Proteomics

Image: A photomicrograph of a cross section of a mouse aorta, the main artery in the body, with a large plaque. Straight red lines toward the upper left are the wall of the aorta. Yellow areas are where housekeeping cells called macrophages are clearing cellular waste (Photo courtesy of Ismail Sergin, Washington University School of Medicine).

Trehalose Boosts Macrophage Ability to Clear Plaques

Cardiovascular disease researchers working with mouse models have found that treatment with the sugar trehalose boosts the activity of the macrophages responsible for clearing the molecular and cellular debris that make up atherosclerotic plaques. More...
22 Jun 2017
Image: The structure of the obscurin protein encoded by the OBSCN gene (Photo courtesy of Wikimedia Commons).

Gene Mutation Leads to Hypertrophic Cardiomyopathy

A team of heart disease researchers explained how a mutation in the gene coding for the obscurin family of proteins leads to the development of an enlarged heart, a condition known as hypertrophic cardiomyopathy. More...
21 Jun 2017
Image: A model of the KRAS protein with important domains highlighted (Photo courtesy of ResearchGate).

Exosomes Prove Superior for Transporting Anticancer MicroRNAs

Cancer researchers used modified exosomes to transport inhibitory siRNA molecules to block the activity of the KRAS oncogene and thereby suppress cancer development in multiple mouse models of pancreatic cancer and significantly increase overall survival. More...
20 Jun 2017
Image: A photomicrograph showing T-cells (red) and tumor cells (green) incubated with control particles (left) or immunoswitch particles (right). The T-cells that have attached to tumor cells are indicated by green arrows (Photo courtesy of Alyssa Kosmides, Johns Hopkins University).

Bifunctional Nanoparticles Show Potential in Cancer Models

To be successful, an immunotherapeutic approach for treating cancer must overcome the immunosuppressive effects of the tumor microenvironment; a novel bifunctional nanoparticle does just that. More...
19 Jun 2017
Image: Dr. Kim and his team are using breakthrough gene-editing technology to develop a new screening tool for Parkinson’s disease. The technology allows scientists in the lab to “light up” and then monitor a brain protein called alpha-synuclein that has been associated with Parkinson’s (Photo courtesy of the University of Central Florida).

CRISPR/Cas9 Technology Used to Help Screen for PD

A team of neurodegenerative disease researchers used CRISPR/Cas9 gene editing technology to introduce a luminescent reporter into the gene that encodes the pathogenic protein alpha-synuclein, an approach that they plan to develop into a screening tool for drugs to treat Parkinson's disease (PD). More...
16 Jun 2017
Image: Research has identified a microRNA that can protect the brain from epilepsy-related trauma and stress (Photo courtesy of Getty Images).

MicroRNA Protects Normal Brain from Trauma and Stress

A microRNA has been identified that helps prevent the normal brain from becoming susceptible to the type of seizures induced by trauma or stress in individuals with epilepsy. More...
14 Jun 2017
Image: A micrograph showing cirrhosis, a form of liver fibrosis (Photo courtesy of Wikimedia Commons).

Cytokine Drives Scar Formation in the Liver

Researchers have identified a cytokine that contributes strongly to the processes involved in the formation of scars in the liver, such as those that form as a consequence of hepatitis C infection. More...
12 Jun 2017
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BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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