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Image: Two megakaryoctes (see arrows) are visible in this slide of bone marrow (Photo courtesy of Wikimedia Commons).

Gene Therapy Treatment Uses Microparticles to Deliver DNA or RNA

A novel gene therapy approach for correcting hereditary blood disorders is based on the use of megakaryocytic microparticles (MkMPs) to deliver plasmid DNAs and small RNAs to hematopoietic stem and progenitor cells (HSPCs). More...
18 Dec 2018
Image: 5-Methylcytosine is a methylated form of the DNA base cytosine that may be involved in the regulation of gene transcription (Photo courtesy of Wikimedia Commons).

DNA Methylation Pattern May Be Biomarker for Cancer Detection

A team of Australian researchers has determined that a characteristic pattern of methylated DNA allows for easy detection of the genomes of cancerous cells and may serve as a universal biomarker for rapid diagnosis of many types of cancer. More...
17 Dec 2018
Image: A strong immune response can be seen in this immunofluorescence image of lung tissue infected with pneumonia where immune cells are stained green and red (Photo courtesy of Colin Buss, Massachusetts Institute of Technology).

Nanoparticle Assay Detects Respiratory Bacteria in Pneumonia Model

Researchers used a mouse pneumonia model to demonstrate how a nanoparticle-based technique could be used to detect Pseudomonas aeruginosa bacteria in infected animals and monitor bacterial clearance from their lungs during the course of antibiotic treatment. More...
13 Dec 2018
Image: Six days after treatment with IGF-1 carried by dendrimer nanoparticles (blue), the particles have penetrated through the cartilage of the knee joint (Photo courtesy of Brett Geiger and Jeff Wyckoff, Massachusetts Institute of Technology).

Deeply Penetrating Nanoparticles Designed to Treat Osteoarthritis

A novel nanoparticle-based drug transport system designed to treat osteoarthritis delivers the anabolic growth factor IGF-1 (insulin-like growth factor 1) directly to injured chondrocytes, which are located deep within a dense layer of cartilage tissue. More...
12 Dec 2018
Image: Endodermal cells, they form organs such as lung, liver and pancreas (Photo courtesy of IDR, Helmholtz Zentrum München).

Diabetes Researchers Convert Stem Cells into Insulin-Producing Cells

A team of stem cell biologists working on the problem of pancreas replacement in patients with type I diabetes identified the extrinsic and intrinsic signaling mechanisms that coordinate the fate-determining transcriptional events underlying the maturation of bipotent pancreatic progenitors and used this information to convert these pancreatic progenitors - derived from human embryonic stem cells - to insulin-producing islet cells. More...
11 Dec 2018
Image: Illustration showing the protein Cas12a (Cpf1) bound to a DNA helix (red and white) (Photo courtesy of T. Yamano and H. Nishimasu, who discovered and published the coordinates of each atom in the protein-DNA complex. James Rybarski used those coordinates and software called PyMol to generate the illustration).

Analytical Tools Reveal Molecular Mechanism of Gene-Editing Tool

A recent paper described the use of advanced analytical techniques to define the mode of action of the gene-editing tool CRISPR/cas12. More...
10 Dec 2018
Image: Graph shows elevated activity of a transcription-factor network that includes the molecule onecut2 in tumors of patients whose prostate cancer resisted hormone therapy (above purple bar) compared with other types (Photo courtesy of the Nature Publishing Group).

Hormone Treatment Linked to Development of Aggressive Cancer

A team of cancer researchers has identified a gene that promotes the growth and spread of the most aggressive type of prostate cancer. More...
06 Dec 2018

BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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