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Drug Discovery

Image: Compared to a control (left), a soluble version of TLR5 (right) reduced the formation of amyloid plaques (brown) in the brains of mice that produced large amounts of human beta-amyloid (Photo courtesy of Chakrabarty et al., 2018).

Vaccination with Receptor Protein Protects Mice against AD

A soluble version of a protein involved in the formation of toxic amyloid plaques was shown to prevent aggregation of amyloid beta (Abeta) and slow development of Alzheimer's disease (AD) in a mouse model. More...
12 Sep 2018
Image: A photomicrograph of the Gram-positive bacterium, Propionibacterium acnes growing in thioglycollate medium. P. acnes bacteria, which normally reside in the sebaceous glands of the skin, are responsible for acne vulgaris, or pimples (Photo courtesy of the [U.S.] Centers for Disease Control and Prevention).

Early Stages Proceed in Development of Acne Vaccine

A potential vaccine to protect against development of acne is based on a virulence factor isolated from the bacteria that causes the severe skin inflammation. More...
11 Sep 2018
Image: Mice fed a diet high in trans fats and cholesterol for 12 weeks show fatty deposits in the liver (red staining) (Photo courtesy of Dr. Brian DeBosch, Washington University School of Medicine).

Blocking Glucose Metabolism Prevents Development of Metabolic Syndrome

A novel approach to preventing diabetes and other manifestations of metabolic syndrome, which includes obesity, diabetes, and fatty liver disease, showed promising results in mouse model systems. More...
03 Sep 2018
Image: With the new method, the researchers were able to image polyclonal antibody/HIV envelope complexes at a resolution of 4.7 angstroms. At this resolution, the researchers discovered that in rabbits, antibodies specific to a vulnerable site on HIV\'s outer glycan layer (blue shapes) are structurally highly convergent and closely resemble a previously isolated monoclonal antibody (green and teal ribbons) (Photo courtesy of Dr. Lars Hangartner, Scripps Research Institute).

Electron Microscopy Technique Boosts Development of Antibody-Based Vaccines

The novel use of an electron microscope imagining technique enabled vaccine developers to follow the design process of structure-based vaccines in real time. More...
22 Aug 2018
Image: In cells under duress, stress granules (in magenta) form outside of the nucleus (in blue). TDP-43 protein in green (arrow) that cannot bind to polyADP ribose (PAR) builds up in large clumps distinct from stress granules (Photo courtesy of Leeanne McGurk, University of Pennsylvania).

PARP-Inhibitors Reduce Damage in Some Neurological Disorders

A recent study found that blocking the activity of the poly(ADP-ribose)polymerase (PARP) family of enzymes reduced the amount of harmful TDP-43 (transactive response DNA binding protein) structures in brain cells under stress and slowed or prevented development of cytoplasmic inclusions found in neurological disorders such as amyotrophic lateral sclerosis (ALS), and some forms of frontotemporal degeneration (FTD). More...
20 Aug 2018
Image: The figure shows two views, frontal and lateral, of the image obtained by CT of the lungs of a mouse with fibrosis (grey areas) before and after receiving nano-therapy directed at senescent cells (Photo courtesy of Guillem Garaulet and Francisca Mulero, Institute for Research in Biomedicine).

Gel Encapsulation Transport System Targets Disease-Related Cells

A novel therapeutic approach uses drugs encapsulated within galacto‐oligosaccharide gel capsules to target diseases that have accumulated a high percentage of senescent cells. More...
10 Aug 2018
Image: Image shows the effect particles coated with phage (red) have on bacterial colonies (green). The dark green areas around the particles show areas where bacteria are being killed. (Photo courtesy of Rachit Agarwal, Garcia Laboratory, Georgia Institute of Technology).

Bacteriophages Delivered by Dry Powder Cure Lung Diseases in Model

A novel antibacterial transport system utilized a dry powder approach to deliver microparticles coated with bacteriophages to difficult to access areas in the lungs. More...
03 Aug 2018

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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