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Drug Discovery

Image: A simplified diagram of the structure of Epstein-Barr virus (EBV) (Photo courtesy of Wikimedia Commons).

New Anticancer Drugs Interfere with DNA Binding Properties of EBV

The recent synthesis of small molecular drugs that interfere with the DNA binding properties of Epstein-Barr virus (EBV) suggests that it may be possible to develop medications for the treatment of EBV-associated cancers. More...
18 Mar 2019
Image: The structure of the third complement (C3) protein (Photo courtesy of Wikipedia).

Natural Antibodies Can Prevent Adverse Immune Reactions

Natural antibodies, in particular IgG, have been shown to be a critical factor that determines the efficiency of complement activation in different subjects and by different nanomaterials. More...
11 Mar 2019
Image: Yerba Santa growing on roadside in California, USA (Photo courtesy of Wikimedia Commons).

Sterubin Shown to Possess Neuroprotective and Anti-inflammatory Properties

Sterubin, a flavonoid isolated from extracts of a North American medicinal plant was found to have potent neuroprotective and anti-inflammatory properties. More...
05 Mar 2019
Image: A confocal microscope image shows the SA-4-1BBL (green color) bound to its receptor on an immune cell (red color) to initiate an immune activation cascade to fight cancer (Photo courtesy of the University of Louisville).

Engineered Ligand Protein Protects Mice from Developing Cancer

A team of cancer researchers has developed a recombinant protein molecule that, when injected into mice, was able to protect the animals against subsequent tumor challenge irrespective of the tumor type. More...
04 Mar 2019
Image: A simple treatment using four small molecules converts human astrocytes - a common type of cells in the nervous system - into new neurons, which develop complex structures after four months (Photo courtesy of the Gong Chen Laboratory, Pennsylvania State University).

Cocktail of Molecules Induces Astrocytes to Transform into Neurons

A team of neurobiological researchers developed a simple recipe requiring only three or four small molecules to convert human fetal astrocytes into neurons. More...
20 Feb 2019
Image: The diagram illustrates the path of action of a new imaging and platelet targeting chemotherapy agent for the early detection and treatment of cancers (Photo courtesy of the Baker Heart and Diabetes Institute).

Anti-Cancer Treatment Targets Activated Platelets in Tumor Microenvironment

A novel chemotherapeutic agent transport system is based on the binding of an antibody-drug conjugate specifically directed to a surface protein on activated platelets in the tumor microenvironment. More...
19 Feb 2019
Image: The structure of the NRAS protein (Photo courtesy of Wikimedia Commons).

Experimental Drug Blocks Development of Malignant Melanomas

A promising experimental drug may prevent growth and spread of malignant melanomas having a mutation in the NRAS gene. More...
14 Feb 2019

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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