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Drug Discovery

Image: Pancreatic cancer cells deficient in the expression of the human gene known as Schlafen 11 and resistant to chemotherapy (left panels) were re-sensitized to chemotherapeutic treatment (middle and right panels) by inhibiting the expression of the transfer RNA known as tRNA-Leu-TAA through specially designed antisense oligonucleotides (Photo courtesy of Manqing Li, Michael David Laboratory, University of California, San Diego).

Proposed Treatment Aims to Re-Sensitize Cancer Cells

Cancer cells that lack the Schlafen 11 gene frequently develop resistance to commonly used DNA-damaging (DDA) chemotherapeutic drugs, but recent research suggests that this resistance may be reversible. More...
08 Nov 2018
Image: The structure of CDK9 (cyclin-dependent kinase 9) protein (Photo courtesy of Wikimedia Commons).

Novel CDK9 Inhibitor Prevents Cancer Growth

Blocking the activity of cyclin-dependent kinase 9 (CDK9) has been shown to be a way to reactivate tumor suppressor genes silenced be growing tumors, which could spur development of chemotherapeutic agents designed to specifically target this enzyme. More...
06 Nov 2018
Image: A micrograph showing a DNA drug (CpG-STAT3 antisense, red) penetrating human prostate cancer cells within 15 minutes of exposure (CpG-STAT3 antisense, red; intracellular vesicles, green) (Photo courtesy of City of Hope).

Antisense DNA Drug Cures Prostate Cancer in Model

A team of cancer researchers has developed a novel oligonucleotide drug that destroys prostate tumors by overcoming tumor immune tolerance and activating the antitumor immune response. More...
31 Oct 2018
Image: The stem and bark of Camptotheca acuminate (common name xi shu), has been used for centuries in traditional Chinese medicine (Photo courtesy of Wikimedia Commons).

Candidate Anticancer Drug Effectively Treats Drug-resistant Pancreatic Cancer

A candidate anticancer drug derived from the medicinal bark of a Chinese tree was shown to effectively treat drug-resistant pancreatic cancer alone or in combination with other pancreatic cancer chemotherapeutic drugs. More...
29 Oct 2018
Image: A diagram of a fundamentally new molecule that can halt proliferation and growth of breast cancer cells in the laboratory (Photo courtesy of the Stevens Institute of Technology).

Molecular Scaffolds Promise Drug Synthesis in Breast Cancer Treatment

A recently developed class of molecular scaffolds for treatment of breast cancer promises to facilitate the synthesis of drugs capable of degrading or inhibiting estrogen receptors (ERs). More...
16 Oct 2018
Image: A three-dimensional (3D) representation of the chemical structure of trans-resveratrol (Photo courtesy of Wikimedia Commons).

Targeted Delivery of Resveratrol Prevents Lung Cancer in Model

A team of Swiss cancer researchers prevented development of lung cancer in a mouse model system using a method, which they had developed, that delivered high concentration dosages of the natural cancer chemoprevention compound resveratrol directly to the animals' lungs. More...
15 Oct 2018
Image: The structure of the recently developed cancer drug Metavert (Photo courtesy of the U.S. National Library of Medicine).

Candidate Cancer Drug Blocks Growth and Reverses Drug Resistance

A candidate drug for treatment of pancreatic cancer was shown to slow growth and spread of the disease in cell cultures and reverse drug resistance in preclinical animal models. More...
09 Oct 2018

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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