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09 Apr 2018 - 12 Apr 2018
10 Apr 2018 - 13 Apr 2018

Drug Discovery

Image: A synthetic, injectable hydrogel developed at Rice University boosts the toxicity of a new class of cancer-fighting immunotherapy drugs. This scanning electron microscopy image shows the self-assembled nanofibers that make up the hydrogel (Photo courtesy of Hartgerink Research Group, Rice University).

Hydrogel Developed for Controlled Release of Immunotherapeutic Drugs

Cancer researchers have developed an injectable hydrogel designed to expedite the controlled release of a cyclic dinucleotide drug for enhanced cancer immunotherapy. More...
21 Mar 2018
Image: The process of extracting proteolipid material, protein enrichment, and vesicular formulation of leukosomes (Photo courtesy of the Houston Methodist Research Institute).

Biomimetic Nanoparticles Prove Effective for Biotherapeutic Drug Transport

Nanoparticles coated with proteins from immune system leukocytes were shown to provide an effective transport and delivery system for biotherapeutic drugs. More...
19 Mar 2018
Image: The crystal Structure of K-Ras G12C (Photo courtesy of the Yale Cancer Center).

New Cancer Treatments Aimed at Preventing Drug Resistance

Cancer researchers have proposed a method for preventing development of resistance to chemotherapy that targets a mutation that appears spontaneously in certain lung tumors. More...
14 Mar 2018
Image: The 123B9 dimeric peptide (right panel) has a scorpion-like shape with two arms that bind to EphA2-expressing cancer cells and a tail (brown) comprising the cytotoxic chemotherapeutic agent paclitaxel. The compound recognizes the surface of cancer cells that are rich in EphA2 (labeled in red in the left panel) and deliver the cytotoxic agent (Photo courtesy of the Pellecchia Laboratory, University of California, Riverside).

Oncogene Used as Drug Transporter to Block Tumor Growth

A potent peptide-drug conjugate that targets the EphA2 oncogene was shown to reduce circulating cancer cells and metastases in breast cancer models. More...
07 Mar 2018
Image: When injected into tumors, this therapy forms a gel to attack cancer cells (Photo courtesy of the Gu Laboratory, University of North Carolina).

Novel Hydrogel Slows Tumor Growth and Prevents Recurrence

A team of cancer researchers developed a novel hydrogel device designed to be injected at the site of a tumor, where it forms a scaffold for sequential release of chemotherapeutic and immunotherapeutic drugs. More...
06 Mar 2018
Image: Knee joints from control and FoxO deficient mice. The areas in red are joint cartilage, which is destroyed in FoxO deficient mice after treadmill running (Photo courtesy of the Lotz Laboratory, The Scripps Research Institute).

FOXO Protein Deficiency Linked to Osteoarthritis Severity

A mouse model that had been genetically engineered to lack FOXO (Forkhead box) proteins in cartilage was found to exhibit worse arthritis with aging and increased cartilage degradation in response to surgically induced arthritis. More...
03 Mar 2018
Image: Osteoarthritis leads to the progressive loss of joint cartilage, shown in red (Photo courtesy of Nancy Liu/Denis Evseenko Laboratory, University of Southern California).

Novel Drug Candidate Reverses Arthritic Bone Loss in Models

A small molecule drug candidate was found to induce bone regeneration and reduce inflammation in various rat osteoarthritis models. More...
21 Feb 2018

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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