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Drug Discovery

Image: A representation of the movement of the flower-like particle as it makes its way to deliver therapeutic genes (Photo courtesy of Washington State University).

Fluorinated Nanoparticles Facilitate Drug Transfer to Cellular Cytosol

In a proof-of-principle study, novel "nanoflower" drug transporters were used to successfully deliver model drug analogues to cells growing in culture. More...
22 Jan 2019
Image: Treatment with the drug D-PDMP reduced beta-1,4-GalT-V protein levels in human colorectal cancer cells and killed cancer cells (Photo courtesy of Dr. Subroto B. Chatterjee, Johns Hopkins University).

Blocking Colorectal Cancer Growth by Inhibiting Glycosphingolipid Synthesis

Results of a recent study suggested that inhibition of glycosphingolipid (GSL) synthesis could be a novel approach for the treatment of colorectal cancer. More...
21 Jan 2019
Image: Growth of the newly discovered Streptomyces sp. myrophorea, so named because it produces a distinctive fragrance similar to that of oil of wintergreen. Although superficially resembling fungi, Streptomyces are true bacteria and are the source of two-thirds of the various frontline antibiotics used in medicine (Photo courtesy of G. Quinn, Swansea University).

Bacteria from Medicinal Soil Kills Antibiotic-Resistant Pathogens

A novel strain of Streptomyces bacteria isolated from an Irish bog with soil having a long tradition of use in folk medicine was shown to possess potent anti-microbial properties especially against antibiotic resistant pathogens. More...
07 Jan 2019
Image: A digitally colorized transmission electron microscopic (TEM) image of Zika virus. Virus particles, colored blue, are 40 nanometers in diameter, with an outer envelope and an inner dense core (Photo courtesy of the CDC).

Zika Vaccine Protects without Inducing Antibody Production

A novel vaccine against Zika virus infection, which was successfully tested in mouse models, is based on the delivery of genes for Zika virus structural proteins via attenuated adenovirus vectors. More...
02 Jan 2019
Image: NanoBEADS transporters were constructed by conjugating poly(lactic‐co‐glycolic acid) nanoparticles with tumor‐targeting Salmonella typhimurium bacteria (Photo courtesy of Virginia Tech).

Targeted System Uses Conjugated Bacteria to Deliver Drugs

A novel delivery system for anti-cancer chemotherapeutic agents utilizes attenuated bacteria that have been conjugated to polymeric nanoparticles to transport the drugs via a targeted, passive process. More...
31 Dec 2018
Image: This transmission electron micrograph (TEM) depicts the liberated, chain-like, ribonucleic acid (RNA) genome of the respiratory syncytial virus (RSV) pathogen. RSV is a negative-sense, enveloped RNA virus. The virion is variable in shape and size, with a diameter ranging between 120 and 300 nanometers (Photo courtesy of the CDC).

Vaccine Effectively Protects Mice against RSV Infection

The potential of a microneedle skin patch for vaccination against respiratory syncytial virus (RSV) has been demonstrated in a mouse model system. More...
26 Dec 2018
Image: A model of the active site of the kinase GSK-3 (glycogen synthase kinase 3) (Photo courtesy of Wikimedia Commons).

Suppression of a Specific Kinase Blocks Growth of Dependent Tumors

A recent paper revealed that the enzyme glycogen synthase kinase 3 (GSK3) was required for the in vitro and in vivo growth and survival of human mutant KRas-dependent tumors but was dispensable for mutant KRas-independent tumors. More...
20 Dec 2018

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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