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22 May 2018 - 25 May 2018
26 May 2018 - 27 May 2018
04 Jun 2018 - 07 Jun 2018

Drug Discovery

Image: A model of cambinol (small yellow structure near top center) binding to nSMAse2 enzyme (Photo courtesy of Kanagasabai Vadive, University of California, Los Angeles).

Oral Cambinol Treatment Shows Potential for Blocking Development of AD

Alzheimer's disease researchers have shown that the low molecular weight drug cambinol blocks the formation of exosomes that allow the spread of insoluble, toxic tau aggregates, which are characteristic of the neurodegenerative disorder. More...
16 May 2018
Image: A colorized scanning electron micrograph (SEM) of a red blood cell infected with malaria parasites, which are shown in blue (Photo courtesy of the U.S. National Institute of Allergy and Infectious Diseases).

PB Transposon Mutagenesis Identifies Malaria Genes and Drug Targets

A team of genome researchers took advantage of the unusual nucleotide composition of Plasmodium falciparum DNA to create mutant strains of the malaria parasite in order to identify essential genes and potential drug targets. More...
15 May 2018
Image: Nanoparticles loaded with the dual immunotherapy platform (Photo courtesy of UNC Lineberger Comprehensive Cancer Center).

Nanoparticle Delivery Increases Effectiveness of Anti-Cancer Immunotherapy

A nanoparticle delivery system was used to transport antibody-based immunotherapeutic drugs in trials conducted in cancer cell in vitro cultures and in animal models. More...
10 May 2018
Image: An illustration of blood vessels including artery, arteriole, capillaries, vein and venule (Photo courtesy of the [U.S.] National Cancer Institute).

Protein Supports Optimal Vascular System Performance

A protein has been identified that acts as a sensor of mechanical stimulation and is essential for sensing blood flow and supporting optimal performance of the vascular system. More...
01 May 2018
Image: A micrograph of a pancreatic cancer spheroid culture (Photo courtesy of Dr. Shurong Hou, Scripps Research Institute).

HTS Method Based on 3D Tumor Organoid Cultures

A drug development team has described a high-throughput screening (HTS)-compatible method – based on three-dimensional (3D) tumor organoids – for evaluating multiple chemical compounds for potential chemotherapeutic drug candidates. More...
30 Apr 2018
Image: A photomicrograph showing fibrotic heart cells from a patient who had heart failure. The cells have an elaborate fibronectin matrix (shown in red), which causes fibrosis and heart damage (Photo courtesy of Cincinnati Children\'s Hospital Medical Center).

Inhibiting Fibronectin Polymerization Reduces Injury to Cardiac Muscle

Working with a mouse model of human heart disease, researchers showed that interfering with fibronectin (FN) polymerization or its genetic deletion in fibroblasts would attenuate cardiac myofibroblasts (MF), fibrosis, and improve cardiac function following heart attack related injury. More...
24 Apr 2018
Image: A micrograph of the West Nile virus (shown in yellow) (Photo courtesy of Wikimedia Commons).

Vaccine Cures and Protects against West Nile Virus

Treatment with a novel siRNA-based vaccine offered efficient late-stage therapy and facilitated development of natural long-term immunity against West Nile virus in a mouse model system. More...
18 Apr 2018

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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