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Image: Surface model of Leishmania’s ribosomal large subunit (rLSU) based on the first high-resolution structure, obtained by 2.8-A° cryo-EM. Circled are the locations of three focal points of rLSU rRNA segmentation in regards to the ribosome exit tunnel. 26S rRNA segment-terminals in the leishmanial ribosome were found to converge to these three separate focal points, all located on the solvent-exposed side of the rLSU. The 5.8S rRNA chain is represented as yellow surface and all other chains are represented as cartoon tubes. The study revealed the fragmented nature of leishmanial rRNA and irregular distribution of rRNA modifications, with implications for drug development against Leishmania and related parasites (Photo courtesy of Cell Reports).

High-Resolution Analysis of Leishmanial Ribosome Provides Clues for Drug Design

Derived from a 2.8-Å cryo-EM map, researchers have achieved an atomic resolution structure of the Leishmania donovani large ribosomal subunit (rLSU). Comparison with other eukaryotes and with bacteria provides an important framework for better understanding ribosome biogenesis and a solid structural basis for developing highly selective therapeutics against Leishmania and closely related parasites. More...
08 Sep 2016
Image: A 3D nanofiber net formed by the supergelators to trap oil molecules (Photo courtesy of IBN at A*STAR / Institute of Bioengineering and Nanotechnology).

Effective Cleanup with Smart Material That Forms Oil-Trapping Net

Researchers have developed supergelators – an organic oil-scavenging material that rapidly forms a 3D net to trap oil molecules, gelatinizing into solidified masses that can be more easily removed from oceans, lakes, and other aqueous solutions. More...
07 Jul 2016
Image: A space-filling model of the anticonvulsant drug carbamazepine (Photo courtesy of Wikimedia Commons).

Wastewater May Contaminate Crops with Potentially Dangerous Pharmaceuticals

Reclaimed wastewater used to irrigate crops is contaminated with pharmaceutical residues that can be detected in the urine of those who consumed such produce. More...
29 Apr 2016
Image: Scientists had viewed ant antennae as being used only to receive information – new research has demonstrated that they also transmit critical social signals (Photo courtesy of the University of Melbourne).

Ant Antennae Communicate Vital Social ID Information

Scientists have shone new light on the complexities of insect communication with the discovery that ants not only pick up information through their antennae, but also use them to convey social signals.   More...
05 Apr 2016

Link Found Between Brain Metabolism and Fluid Intelligence

By measuring a metabolic activity marker using magnetic resonance spectroscopy, a new study in young adults has indicated that healthy brain metabolism corresponds with fluid intelligence, a measure of one’s ability to solve unusual or complex problems.  More...
03 Apr 2016

Failing Hearts Switch Fuels to Continue Generating Energy

A new study provides fresh biochemical insight into heart failure and may eventually lead to new diagnostic and pathology tests as well as therapeutic targets to prevent or slow progression of the disease.   More...
24 Feb 2016
Image: A microscopic image of glioblastoma cells growing along the fibers of the 3D scaffold (Image courtesy of (Photo courtesy of Dr. Andrew Wan laboratory, Institute of Bioengineering and Nanotechnology, Singapore).

Key Finding May Lead to Improved Treatment of Aggressive Brain Cancers

Researchers have shown an essential role for the cell microenvironment in the growth of glioblastoma brain cancer cells, a discovery that could lead to a breakthrough in fighting such deadly cancers.  More...
20 Jan 2016
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The Biochemistry channel of BioResearch covers the chemical process of biomolecules and biochemical processes from enzyme-catalyzed reactions to signal transduction, from the biochemistry of cell metabolism down to cell-membrane transport.
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