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Drug Discovery

Image: Leukemia cells (green) interact with blood vessels (blue) via the molecule CD98 (Photo courtesy of the University of California, San Diego).

Cell Surface Glycoprotein Critical for Acute Myeloid Leukemia

The cell surface glycoprotein CD98 was identified as a key factor required for growth and spread of acute myeloid leukemia (AML). More...
08 Nov 2016
Image: The protein produced by the adenomatous polyposis coli (APC) tumor suppressor gene (Photo courtesy of Wikimedia Commons).

Candidate Drug Kills CRCs with Mutated Tumor Suppressor Gene

A candidate small molecule drug for treatment of colorectal cancer acts by blocking cholesterol biosynthesis in a subset of tumor cells that carry a mutated version of a gene that normally suppresses tumor formation. More...
04 Nov 2016
Image: The experimental drug NGI-1 slows cancer growth by blocking glycosylation of the epidermal growth factor receptor (EGFR), which is shown in the above diagram (Photo courtesy of Wikimedia Commons).

Experimental Drug Slows Lung Cancer Growth by Blocking Protein Glycosylation

An interesting new experimental anti-cancer drug slows growth of certain lung tumor cells by preventing the glycosylation of critical cell surface receptor proteins. More...
03 Nov 2016
Image: Photomicrographs show that placebo-treated cells (left) have far more lipid (red) production compared to ND-646 treated cells (right) (Photo courtesy of the Salk Institute).

Experimental Drug Shrinks Lung Tumors by Blocking Fatty Acid Synthesis

An experimental drug that blocks the activity of the enzyme that regulates de novo fatty acid synthesis caused a dramatic reduction in the size of tumors in animal models of non-small-cell lung cancer (NSCLC). More...
27 Oct 2016
Image: Tumor growth in the xenograft bladder cancer model was monitored using a bioluminescence imaging system. Forty-five days after inoculation, metastatic tumors were detected in the lungs, liver and bone (Photo courtesy of Scientific Reports).

Flufenamic Acid Slows Spread of Bladder Cancer in Mouse Model

The enzyme aldo-keto reductase 1C1, which could be suppressed by the anti-cold drug flufenamic acid, was found to be highly active in metastatic human bladder cancer and represents a potent molecular target for treating the disease. More...
26 Oct 2016
Image: A microscopic view of a typical neuroblastoma with rosette formation (Photo courtesy of Dr. Maria Tsokos, National Cancer Institute).

Neuropeptide May Serve as Biomarker for Neuroblastoma Patients

A study has found the common nerve protein Neuropeptide Y (NPY) to be elevated in the blood of those with an aggressive form of neuroblastoma, suggesting that NPY could serve as biomarker in a prognostic and/or treatment monitoring test, and as a new target for developing a more effective therapeutic drug for this early childhood cancer. More...
26 Oct 2016
Image: Neutralizing antibodies that bind to specific antigens on the flu virus may aid in the development of a universal influenza vaccine (Photo courtesy of Dr. Matthew Miller, McMaster University).

Mechanism Described for Cytotoxicity Regulation against Influenza A

A new discovery that revealed how neutralizing antibodies bind to specific antigens on the flu virus may aid in the development of a universal influenza vaccine. More...
20 Oct 2016
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The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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