Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Events

06 Jun 2016 - 09 Jun 2016
22 Jun 2016 - 24 Jun 2016
04 Jul 2016 - 06 Jul 2016

Antidiabetes Drug Makes Lung Cancer Susceptible to Radiotherapy

By BiotechDaily International staff writers
Posted on 28 May 2013
Print article
Metformin, an anitdiabetic drug, has been shown to slow the growth of lung cancer cells and makes them more likely to be killed by radiotherapy.

Scientists from McMaster University (Hamilton, ON, Canada) discovered that metformin acted on the defense mechanisms non-small-cell lung tumors—the most typical form of the disease—use to resist radiotherapy. They published their findings April 30, 2013, in the British Journal of Cancer.

Lung cancer cells typically adapt to radiotherapy by activating survival processes that make them resistant to the treatment and even helps them to grow faster. However, by examining lung cancer cells grown in the lab and in mice, the researchers showed that metformin reverses this effect, once again making them sensitive to radiotherapy. Significantly, the researchers utilized “real life” levels of the drug in their experiments, similar to those already used for treating diabetes.

Metformin seems to work by enhancing the damage-detection signals sent within cancer cells in response to radiotherapy, over-riding the cells’ survival mechanisms. These signals blocks cancer cells from producing the new proteins they need to grow rapidly, prevents them from making new cells and eventually encourages them to die.

Dr. Theodoros Tsakiridis, study author and a radiation oncologist at the Juravinski Cancer Center and McMaster University, said, “Our study shows that the diabetes drug metformin can stop lung cancer cells from growing and makes them more sensitive to treatment by radiotherapy. “We’re now working with other institutions to develop a clinical trial that will investigate metformin in lung cancer patients treated with radiotherapy. If we can prove that this works in patients then we could have a potentially powerful weapon in the fight against the disease.”

In spite radiotherapy being an effective treatment for many cancers, it has a limited effect for lung cancer patients. Dr. Kat Arney, science information manager at Cancer Research UK (London, UK), said, “Lung cancer remains one of the most difficult cancers to treat, with less than 10% of people surviving the disease for at least five years. We urgently need new and better ways of treating lung cancer and this research takes us a step towards making radiotherapy a more potent treatment. To improve the chances for lung cancer patients, Cancer Research UK is planning to increase significantly its investment in research into this form of the disease, so that patients can benefit from new and improved treatments sooner.”

Related Links:

McMaster University



Print article

Channels

Genomics/Proteomics

view channel
Image: Follicular helper T-cells (TFH cells, shown in blue) play a crucial role in the maturation of antibody-producing B-cells (shown in green). Activated B-cells give rise germinal centers (shown in red), where mature B-cells proliferate and produce highly specific antibodies against pathogens. Top left: normal germinal center in a mouse tonsil. All others: Germinal centers fail to form when the interaction between ICOS and TBK1 is interrupted (Photo courtesy of Dr. Kok-Fai Kong, La Jolla Institute for Allergy and Immunology).

Molecular Pathway Controlling High-affinity Antibody Production Identified

A molecular pathway has been identified that controls formation of follicular helper T-cells (TFH cells) germinal centers and production of high-affinity antibodies through interaction with the inducible... Read more

Drug Discovery

view channel

Experimental Small-Molecule Anticancer Drug Blocks RAS-binding Domains

The experimental small-molecule anticancer drug rigosertib was shown to block tumor growth by acting as an RAS-mimetic and interacting with the RAS binding domains of RAF kinases, resulting in their inability to bind to RAS, which inhibited the RAS-RAF-MEK pathway. Oncogenic activation of RAS genes due to point mutations... Read more

Biochemistry

view channel
Image: A space-filling model of the anticonvulsant drug carbamazepine (Photo courtesy of Wikimedia Commons).

Wastewater May Contaminate Crops with Potentially Dangerous Pharmaceuticals

Reclaimed wastewater used to irrigate crops is contaminated with pharmaceutical residues that can be detected in the urine of those who consumed such produce. Investigators at the Hebrew University... Read more

Lab Technologies

view channel

Huge Modifiable Biomedical Database to Be Available on the Wikidata Site

Genome researchers are exploiting the power of the open Internet community Wikipedia database to create a comprehensive resource for geneticists, molecular biologists, and other interested life scientists. While efficiency in generating scientific data improves almost daily, applying meaningful relationships between... Read more

Business

view channel

European Biotech Agreement to Promote Antigen-Drug Conjugation Technology

Two European biotech companies have joined forces to exploit and commercialize an innovative, site-specific ADC (antigen-drug conjugate) conjugation technology. ProBioGen (Berlin, Germany), a company specializing in the development and manufacture of complex glycoproteins and Eucodis Bioscience (Vienna, Austria), a... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.