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05 Mar 2017 - 09 Mar 2017
20 Mar 2017 - 23 Mar 2017
12 Apr 2017 - 14 Apr 2017


Image: An adult heart muscle cell, grown in a newborn rat heart (Photo courtesy of Chulan Kwon, Johns Hopkins University School of Medicine).

Mature Heart Muscle Cells Created from Implanted Stem Cells

Bypassing a longstanding tissue culture challenge, researchers have succeeded in generating mature and viable human heart muscle cells in the laboratory by implanting, into newborn rat hearts, induced pluripotent stem cells (I-PSCs) from a healthy adult or an adult with a type of heart disease. The host rat heart provides the signals and chemistry needed by the implanted human immature heart muscle cells to progress and overcome the developmental block that has otherwise prevented their maturation in lab cultures. More...
10 Feb 2017
Image: A photomicrograph showing numerous immune suppressive cells in green and yellow, infiltrating the tumor mass (tumor cells in white). By depleting these immune suppressive cells, immunotherapy becomes much more effective (Photo courtesy of the University of Michigan).

Combined Gene and Immunotherapy Shows Potential for Aggressive Brain Tumors

A novel approach that combined gene and immunotherapy demonstrated considerable potential in a mouse model as a method for treating the aggressive brain tumor glioblastoma multiforme (GBM). More...
17 Jan 2017
Image: Induction of reprogramming improved muscle regeneration in aged mice. (Left) impaired muscle repair in aged mice; (right) improved muscle regeneration in aged mice subjected to reprogramming (Photo courtesy of the Salk Institute for Biological Studies).

Reprogramming Therapy Reverses Signs of Aging in Mouse Progeria Model

Researchers on the biology of aging have shown that when the type of cellular reprogramming used to produce pluripotent stem cells is applied intermittently to whole animals the aging process can be arrested or reversed without stimulating cancer development. More...
28 Dec 2016
Image: Photomicrographs of the engineered cells (nuclei in blue) with HIF-1 visualized (in red). In the left hand panel, cells are in hypoxia but no doxycycline is present, therefore HIF-1 remains active (red dots). In the right hand panel, the cells are grown in hypoxia and in the presence of doxycycline, therefore the cyclic peptide inhibitor is produced and HIF-1 is inhibited, as demonstrated by the absence of the red dots (Photo courtesy of the University of Southampton).

Gene Therapy Prevents Cancer Cells from Surviving in Hypoxic Environment

Gene therapy techniques were used to insert a peptide into cultures of human cancer cells that blocked their ability to use the enzyme Hypoxia-inducible factor-1, a heterodimeric transcription factor that enables cell survival under low oxygen conditions by altering the transcription of over 300 genes. More...
08 Dec 2016
Image: Indirect immunofluorescence on a patient’s intestinal lining shows anti-enterocyte antibodies. Enterocytes are the cells of the intestinal lining (Photo courtesy of the NIH).

Successful Treatment of Enteritis Due to Newly Discovered Gene Mutation

Researchers report successful treatment of an adult patient with severe chronic autoimmune enteritis by using the drug Vedolizumab to target the effect on T-cell function of a mutation identified in the patient’s CTLA-4 gene. Vedolizumab may also help skin cancer patients with enteritis due to therapy with Ipilimumab. More...
07 Dec 2016
Image: An artist\'s concept of a domain-swapped T-cell receptor (TCR) engaging a peptide presented by a tumor cell on a major histocompatibility complex (MHC) molecule. In TCR gene therapy, genes encoding a tumor-specific TCR are introduced to a patient\'s T-cells, retargeting them to attack cancer cells. Swapping the constant domains between the alpha and beta chains of the tumor-specific TCR prevents these chains from mispairing with the TCR chains resident to each T-cell, which can result in autoimmune disease (Photo courtesy of the California Institute of Technology).

Modified T-Cells Attack Tumors without Triggering Autoimmune Disease

A team of molecular immunologists has devised a method to direct T-cells to recognize and fight cancer cells without risk of the modified cells attacking normal tissues and thereby triggering autoimmune disease. More...
22 Nov 2016
Image: In this image, the top row shows few T-cells in untreated mice, while the bottom rows show many T-cells produced after immunotherapy treatment (Photo courtesy of Massachusetts Institute of Technology).

Novel Immunotherapy Approach Shrinks or Eliminates Advanced Tumors

A novel four-component approach to anti-cancer immunotherapy overcame the complex network of immunosuppressive pathways present in advanced tumors and caused shrinkage of several types of tumors in different mouse models. More...
03 Nov 2016

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