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Molecular Light Shed on “Dark” Cellular Receptors

Scientists have created a new research tool to help find homes for orphan cell-surface receptors, toward better understanding of cell signaling, developing new therapeutics, and determining causes of drug side-effects.  More...
24 Nov 2015

Novel Gene Therapy Treatment Extends Life of Mice Severely Affected by Muscular Dystrophy

An alternative gene therapy approach was used to successfully treat a mouse model of Duchenne muscular dystrophy.  More...
11 Oct 2015

Whales Could Hold the Answer for Synthetic Blood

Ultra-stable proteins that allow deep-diving whales to remain active while holding their breath could help create lifesaving synthetic blood, claims a new study.  More...
07 Oct 2015

Entamoeba hystolytica Manipulates Host Ion Transport Proteins to Cause Cell Death

A team of molecular microbiologists has found that immunity to infection by the parasitic amoeba Entamoeba hystolytica could be induced in humans by using RNAi technology to block the genes controlling the activity of potassium ion transporter proteins.  More...
06 Oct 2015

Selective Ribosome-Targeting Drug with Low Ototoxicity Could Provide Safer Treatment Option for Leishmaniasis

In a multidisciplinary biological study, researchers have shed new light on the mechanism of action of a potent drug for leishmaniasis, the natural aminoglycoside paromomycin, and have found that a new synthetic derivative of PAR may provide a far lower risk of irreversible hearing loss side-effects, probably via its more selective targeting of cytosolic (vs. mitochondrial) ribosomes.  More...
02 Sep 2015

Ancient Viruses Built from Computer Models May Improve Gene Therapy Delivery

An advanced computer modeling strategy was used to design ancient forms of adeno-associated viruses, which were then synthesized in the laboratory for use as potential delivery vectors for gene therapy.  More...
11 Aug 2015

New Biomarkers May Serve as Companion Diagnostics for Patients Being Treated with IL-2

A transcriptional-profiling study has identified biomarkers related to efficacy of interleukin-2 treatment and has identified patient age as a key determining factor of clinical efficacy.   More...
02 Aug 2015

BioResearch Therapeutics channel deals with all aspects of therapies beyond the five-year horizon.
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