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Selective Ribosome-Targeting Drug with Low Ototoxicity Could Provide Safer Treatment Option for Leishmaniasis

In a multidisciplinary biological study, researchers have shed new light on the mechanism of action of a potent drug for leishmaniasis, the natural aminoglycoside paromomycin, and have found that a new synthetic derivative of PAR may provide a far lower risk of irreversible hearing loss side-effects, probably via its more selective targeting of cytosolic (vs. mitochondrial) ribosomes.  More...
02 Sep 2015

Ancient Viruses Built from Computer Models May Improve Gene Therapy Delivery

An advanced computer modeling strategy was used to design ancient forms of adeno-associated viruses, which were then synthesized in the laboratory for use as potential delivery vectors for gene therapy.  More...
11 Aug 2015

New Biomarkers May Serve as Companion Diagnostics for Patients Being Treated with IL-2

A transcriptional-profiling study has identified biomarkers related to efficacy of interleukin-2 treatment and has identified patient age as a key determining factor of clinical efficacy.   More...
02 Aug 2015
Image: New lung cells are continuously created to replace the damaged ones: Lung tissue six weeks after stem cell transplantation (left) and 16 weeks after transplantation (right). Cells that originated in the transplanted stem cells are green, as opposed to the uncolored host lung cells (Photo courtesy of the Weizmann Institute of Science).

Bone Marrow Transplantation Techniques Are Successfully Adapted for Lung Repair

A new approach for repairing the damage caused to lung tissue by diseases such as emphysema, bronchitis, asthma, and cystic fibrosis is based on transplanting embryonic stem cells into damaged lungs that have been conditioned by radiation treatment.  More...
29 Jul 2015
Image: Using a transmission electron microscope (TEM): (A) a bare nanoparticle, (B) a nanoparticle prepared for coating and (C) a nanoparticle coated with a thin layer of drug-delivering hydrogels (Photo courtesy of Dr. Jennifer West, Duke University).

Drug Augmented, Light-Activated Nanoparticles Effectively Kill Cancer Cells

The inclusion of a chemotherapeutic agent within a novel class of light-sensitive nanoparticles enhanced their ability to kill cancer cells.  More...
28 Jul 2015

Promising Cancer Immunotherapy Method Relies on Artificial Magnetic Antigen Presenting Cells

Cancer researchers have developed a method based on magnetic nanoparticles that enables the rapid extraction, enrichment, and expansion of a T-cell population that shows great promise as a tool for immunotherapy.  More...
26 Jul 2015

Swimming Nanorobots Could Provide Targeted Drug Delivery

Nano-sized swimmer robots that move in an S-like, undulatory motion could move easily through body fluids to deliver drugs to their targets.  More...
15 Jul 2015

BioResearch Therapeutics channel deals with all aspects of therapies beyond the five-year horizon.


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