Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING
BioConferenceLive
JIB

Genetic Barcode Helping Make Sense of Deluge of Genetic Data

By BiotechDaily International staff writers
Posted on 23 Dec 2013
An enhanced internet research application is helping clinicians and cancer researchers make sense out of a flood of genetic data from close to 100,000 patients and more than 50,000 lab mice.

The tool, called the Gene Expression Barcode 3.0, is will be a key resource in the new age of personalized medicine, in which cancer therapies are customized to the genetic composition of an individual patient’s tumor.

Significant new improvements in the Gene Expression Barcode 3.0 were reported in the January 2014 issue of the journal Nucleic Acids Research, published online December 2013 ahead of print. The senior author Dr. Michael J. Zilliox is from the Loyola University Chicago Stritch School of Medicine (IL, USA) and the co-inventor of the Gene Expression Barcode.

“The tool has two main advantages,” Dr. Zilliox said. “It’s fast and it’s free.” The Gene Expression Barcode is available online (please see Related Links below), and designed and hosted by Loyola University Chicago Stritch School of Medicine. The website is receiving 1,600 unique visitors monthly.

Determining how a patient’s cancer genes are expressed can help a clinician put together a pursonlized treatment. In a tumor cell, for example, certain genes are expressed while other genes are unexpressed. Moreover, different kinds of cancer cells have different patterns of gene expression. Genes are expressed through RNA, a nucleic acid that performs as a messenger to carry out instructions from DNA for making proteins.

Research institutions have made public genetic data from nearly 100,000 patients, most of whom had cancer, and more than 50,000 laboratory mice. However, in raw form, these data are too cumbersome to be of much practical use for most researchers. The Gene Expression Barcode employs sophisticated statistical methods to make this huge amount of data much more user-friendly to researchers.

The barcode algorithm is designed to estimate the genes that are expressed and those unexpressed.  The Gene Expression Barcode is binary coded: the expressed genes are ones and the unexpressed genes are zeroes.

Dr. Zilliox co-invented the Gene Expression Barcode, with Rafael Irizarry, Ph.D. Dr. Zilliox and Irizarry first reported the Gene Expression Barcode in 2007. In 2011, they reported an improved 2.0 version. The Barcode already has been cited in more than 120 scientific articles, and the new 3.0 version will make it even easier and faster for researchers to use, according to Dr. Zilliox.

Related Links:

Gene Expression Barcode
Loyola University Chicago Stritch School of Medicine



comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: Blocking the activity of HSP101 may imprison the malaria parasite inside its protective vacuole within the red blood cell. In the electron micrograph, the malaria parasites appear in blue and uninfected red blood cells are shown in red (Photo courtesy of the [US] National Institute of Allergy and Infectious Diseases).

Heat Shock Protein Plays Critical Role in Malaria Parasite Protein Trafficking

A pair of recent papers described the molecular operators that enable the malaria parasite Plasmodium falciparum to export a large variety of proteins across the parasitophorous vacuolar membrane (PVM)... Read more

Drug Discovery

view channel
Image: Molecular rendering of the crystal structure of parkin (Photo courtesy of Wikimedia Commons).

Cinnamon Feeding Blocks Development of Parkinson's Disease in Mouse Model

A team of neurological researchers has identified a molecular mechanism by which cinnamon acts to protect neurons from damage caused by Parkinson's disease (PD) in a mouse model of the syndrome.... Read more

Therapeutics

view channel
Image: This type of electronic pacemaker could become obsolete if induction of biological pacemaker cells by gene therapy proves successful (Photo courtesy of Wikimedia Commons).

Gene Therapy Induces Functional Pacemaker Cells in Pig Heart Failure Model

Cardiovascular disease researchers working with a porcine heart failure model have demonstrated the practicality of using gene therapy to replace implanted electronic pacemakers to regulate heartbeat.... Read more

Business

view channel

Cancer Immunotherapy Sector Predicted to Surge to USD 9 Billion Across Major Pharma Through 2022

The immunotherapy market will experience substantial growth through 2022, increasing from USD 1.1 billion in 2012 to nearly USD 9 billion in 2022 (corresponding to 23.8% annual growth) in the United Kingdom, United States, France, Germany, Italy, Spain, and Japan, according to recent market research. This notable growth... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.