Features | Partner Sites | Information | LinkXpress
Sign In
Demo Company

New Multimode Microplate Reader Delivers High Resolution Performance

By BiotechDaily International staff writers
Posted on 07 Oct 2013
Image: The Mithras2 LB 943 Multimode Monochromator Reader (Photo courtesy of Berthold Technologies).
Image: The Mithras2 LB 943 Multimode Monochromator Reader (Photo courtesy of Berthold Technologies).
A newly available next generation microplate reader performs luminescence, fluorescence, and absorbance measurements with the sensitivity and resolution usually obtained only from separate, dedicated instruments.

The Berthold Technologies (Bad Wildbad, Germany) Mithras2 LB943 microplate reader is a high-end multimode reader based on monochromator technology. The instrument is equipped with two double monochromators with high blocking efficiency and high f-number (increased transmission) for filter free absorbance and fluorescence measurements.

The Mithras2 was designed to carry out an impressive variety of assays including Luminescence, BRET (Bioluminescence Resonance Energy Transfer), fluorescence, FRET (Fluorescence Resonance Energy Transfer), fluorescence polarization (FP), UV/VIS absorbance, time-resolved fluorescence, and time-resolved-FRET. To accomplish these varied tasks the instrument was designed with a proprietary optical system consisting of separate paths for different reading technologies, thus offering quality analysis usually obtained only from separate dedicated instruments.

The instrument can be configured for up to four reagent injectors programmed to dispense multiple activators or detection reagents with user-adjustable volumes at any time during the measurement process. The injectors are based on proprietary JET injection technology that delivers superior accuracy and precision. Variable injections speeds and "bio-friendly" materials enable injection of live cells.

The Mitras2 can be used to measure enzyme activities, phagocytosis, calcium flux, cell viability, apoptosis, immunoassays, protein and nucleic acid concentrations, and protein-protein interactions. Single and multiple endpoint measurements as well as kinetic and scanning measurements can be performed. The data can be displayed numerically and graphically and may be printed or exported to a spreadsheet.

Related Links:

Berthold Technologies



view channel
Image: A new catalyst that improved the sensitivity of the standard PSA ELISA test by about 110-fold was made of palladium nanocubes coated with iridium (Photo courtesy of Dr. Xiaohu Xia, Michigan Technological University).

Peroxidase Mimic Outperforms Natural Horseradish Peroxidase in ELISA Test

A test-of-concept study demonstrated that a synthetic catalyst that mimics the action of horseradish peroxidase (HRP) could increase the sensitivity of a colorimetric enzyme-linked immunosorbent assay... Read more

Drug Discovery

view channel
Image: Endoscopic image of a bowel section known as the sigmoid colon afflicted with ulcerative colitis. The internal surface of the colon is blotchy and broken in places (Photo courtesy of Wikimedia Commons).

Orally Delivered Curcumin-Loaded Microparticles Effectively Treat Mouse Model of Ulcerative Colitis

Microparticles (MPs) loaded with the efficient anti-inflammatory agent curcumin were found to effectively treat a mouse model of ulcerative colitis. Ulcerative colitis is a chronic relapsing disease... Read more


view channel

Biopharmaceutical Partners Seek Alternatives to Glucocorticoid Steroid Drugs

Collaboration between American and Japanese biopharmaceutical companies is expected to lead to the development of a new class of small molecule drugs for treatment of hematological and inflammatory diseases. Gencia LLC (Charlottesville, VA, USA) and Takeda Pharmaceutical Company Ltd. (Osaka, Japan) announced the formation... Read more


17 Oct 2015 - 21 Oct 2015
25 Oct 2015 - 29 Oct 2015
16 Nov 2015 - 19 Nov 2015
Copyright © 2000-2015 Globetech Media. All rights reserved.