Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH MEDIA
GLOBETECH PUBLISHING LLC

DNA Bricks Have Potential Applications in Several Nanotech and Biotech Fields

By BiotechDaily International staff writers
Posted on 25 Dec 2013
Image: Interlocking DNA bricks create a three-dimensional molecular canvas. Each canvas is composed of many oligonucleotides, or DNA bricks, that have four consecutive eight nucleotide domains. The bricks assemble at right angles to other interlocking bricks, using standard A-T and G-C base pairing (Photo courtesy of Integrated DNA Technologies).
Image: Interlocking DNA bricks create a three-dimensional molecular canvas. Each canvas is composed of many oligonucleotides, or DNA bricks, that have four consecutive eight nucleotide domains. The bricks assemble at right angles to other interlocking bricks, using standard A-T and G-C base pairing (Photo courtesy of Integrated DNA Technologies).
Researchers have been exploiting the unique physical properties of DNA in order to develop applications not related to its role in storing genetic information.

Investigators at Harvard Medical School (Boston, MA, USA) have relied on highly purified oligonucleotides obtained from Integrated DNA Technologies (Coralville, IA, USA) to create three-dimensional DNA constructs or "bricks.” These bricks have potential applications in several different fields such as catalysts in the development of drug compounds or as elements to create electrical circuit boards on the nanometer scale.

A DNA brick is a relatively simple, single-stranded, 32-base DNA oligonucleotide construct. Each brick has four consecutive eight-base domains, and they assemble at right angles to complementary interlocking oligonucleotides guided by these eight-base domains. A computer program developed in the laboratory of Dr. Pen Yin, assistant professor of systems biology at Harvard Medical School, then "paints" the oligonucleotides onto a virtual molecular canvas that is represented as 10 x 10 x 10 cubic volumetric pixel elements or "voxels.” A three-dimensional shape is created by withholding individual voxels from the brick, and the software then determines which oligonucleotides are required to form the resulting three-dimensional canvas structure.

DNA bricks can be easily modified with other functional molecules, such as fluorophores, and can serve as a scaffold for growing other molecular matrices, such as those formed from SiO2, which have many material applications.

Related Links:

Harvard Medical School
Integrated DNA Technologies



WATERS CORPORATION

Channels

Drug Discovery

view channel
Image: Molecular model of the anti-cancer drug 5-fluorouracil (Photo courtesy of Wikimedia Commons).

Novel Microcapsule Approach Reduces Toxic Side Effects of Chemotherapy

Cancer researchers have reduced chemotherapy's toxic side effects by using nanoporous capsules to transport an enzyme to the site of a tumor where it is activated by a selective heating process to convert... Read more

Lab Technologies

view channel
Image: The gene assembly robot, the GeneTheatre (Photo courtesy of Analytik Jena AG).

Genomic Research Laboratories Await New Compact Liquid Handling System

A small footprint benchtop liquid handler that automates multiple gene assembly tasks and associated procedures such as PCR setup is now available for use by biotech and genomic research laboratories.... Read more

Business

view channel

NanoString and MD Anderson Collaborate on Development of Novel Multi-Omic Expression Profiling Assays for Cancer

The University of Texas MD Anderson Cancer Center (Houston, TX, USA) and NanoString Technologies, Inc. (Seattle, WA, USA) will partner on development of a revolutionary new type of assay—simultaneously profiling gene and protein expression, initially aiming to discover and validate biomarker signatures for immuno-oncology... Read more
 

Events

02 Jun 2015 - 03 Jun 2015
15 Jun 2015 - 18 Jun 2015
Copyright © 2000-2015 Globetech Media. All rights reserved.