Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC
GLOBETECH MEDIA

DNA Bricks Have Potential Applications in Several Nanotech and Biotech Fields

By BiotechDaily International staff writers
Posted on 25 Dec 2013
Image: Interlocking DNA bricks create a three-dimensional molecular canvas. Each canvas is composed of many oligonucleotides, or DNA bricks, that have four consecutive eight nucleotide domains. The bricks assemble at right angles to other interlocking bricks, using standard A-T and G-C base pairing (Photo courtesy of Integrated DNA Technologies).
Image: Interlocking DNA bricks create a three-dimensional molecular canvas. Each canvas is composed of many oligonucleotides, or DNA bricks, that have four consecutive eight nucleotide domains. The bricks assemble at right angles to other interlocking bricks, using standard A-T and G-C base pairing (Photo courtesy of Integrated DNA Technologies).
Researchers have been exploiting the unique physical properties of DNA in order to develop applications not related to its role in storing genetic information.

Investigators at Harvard Medical School (Boston, MA, USA) have relied on highly purified oligonucleotides obtained from Integrated DNA Technologies (Coralville, IA, USA) to create three-dimensional DNA constructs or "bricks.” These bricks have potential applications in several different fields such as catalysts in the development of drug compounds or as elements to create electrical circuit boards on the nanometer scale.

A DNA brick is a relatively simple, single-stranded, 32-base DNA oligonucleotide construct. Each brick has four consecutive eight-base domains, and they assemble at right angles to complementary interlocking oligonucleotides guided by these eight-base domains. A computer program developed in the laboratory of Dr. Pen Yin, assistant professor of systems biology at Harvard Medical School, then "paints" the oligonucleotides onto a virtual molecular canvas that is represented as 10 x 10 x 10 cubic volumetric pixel elements or "voxels.” A three-dimensional shape is created by withholding individual voxels from the brick, and the software then determines which oligonucleotides are required to form the resulting three-dimensional canvas structure.

DNA bricks can be easily modified with other functional molecules, such as fluorophores, and can serve as a scaffold for growing other molecular matrices, such as those formed from SiO2, which have many material applications.

Related Links:

Harvard Medical School
Integrated DNA Technologies



Channels

Drug Discovery

view channel
Image: Molecular model of the protein Saposin C (Photo courtesy of Wikimedia Commons).

Nanovesicles Kill Human Lung Cancer Cells in Culture and in a Mouse Xenograft Model

Nanovesicles assembled from the protein Saposin C (SapC) and the phospholipid dioleoylphosphatidylserine (DOPS) were shown to be potent inhibitors of lung cancer cells in culture and in a mouse xenograft model.... Read more

Biochemistry

view channel

Possible New Target Found for Treating Brain Inflammation

Scientists have identified an enzyme that produces a class of inflammatory lipid molecules in the brain. Abnormally high levels of these molecules appear to cause a rare inherited eurodegenerative disorder, and that disorder now may be treatable if researchers can develop suitable drug candidates that suppress this enzyme.... Read more

Lab Technologies

view channel
Image: The FLUOVIEW FVMPE-RS Gantry microscope (Photo courtesy of Olympus).

New Multiphoton Laser Scanning Microscope Configurations Expand Research Potential

Two new configurations of a state-of-the-art multiphoton laser scanning microscope extend the usefulness of the instrument for examining rapidly occurring biological events and for obtaining images from... Read more

Business

view channel

Roche Acquires Signature Diagnostics to Advance Translational Research

Roche (Basel, Switzerland) will advance translational research for next generation sequencing (NGS) diagnostics by leveraging the unique expertise of Signature Diagnostics AG (Potsdam, Germany) in biobanks and development of novel NGS diagnostic assays. Signature Diagnostics is a privately held translational oncology... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.