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12 Apr 2017 - 14 Apr 2017
22 Apr 2017 - 26 Apr 2017
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Genomics/Proteomics

Image: Treatment with fusicoccin-A induces the regeneration of damaged axons towards the center of the injury. The axons are stained in green and the tips of the growing axons, called growth cones, are stained in red (Photo courtesy of McGill University).

Drugs Identified May Stimulate Axon Regeneration

A team of neurological science researchers has identified a class of small molecular growth promotors that may prove to be the basis for drugs designed to correct loss of axons following brain or nervous system injury or other disorders and diseases, including multiple sclerosis and neurodegenerative conditions. More...
21 Mar 2017
Image: According to researchers, a rheumatoid arthritis treatment that suppresses the growth of PTEN mutant cancer cells could lead to targeted therapies against aggressive cancers that have few treatment options (Photo courtesy of Shutterstock).

RA Drug Blocks Growth of PTEN-Mutant Cancers

Cancer researchers have found that a drug approved for treatment of rheumatoid arthritis may block the growth of PTEN-mutant tumors by inhibiting the enzyme dihydroorotate dehydrogenase. More...
17 Mar 2017
Image: A photomicrograph showing stem cell-modeled mouse embryo at 96 hours (left); Mouse embryo cultured in vitro for 48 hours from the blastocyst stage (right). The red part is embryonic and the blue extra-embryonic (Photo courtesy of Sarah Harrison and Gaelle Recher, Zernicka-Goetz Laboratory, University of Cambridge).

Stem Cell Structure to Facilitate In Vitro Embryonic Studies

A biological construct that combines mouse embryonic stem cells and extra-embryonic trophoblast stem cells in a three-dimensional scaffold will allow in vitro studies of cellular interaction in a model that mimics a developing embryo. More...
16 Mar 2017
Image: The organ-on-a-chip platform seeks to recapitulate the complex microenvironment of blood vessels using miniaturized microfluidic devices (Photo courtesy of Joao Ribas, Brigham and Women\'s Hospital).

Biomechanical Stress and Inflammation Linked Using Muscle Cells

A team of biomedical engineers used induced pluripotent stem cells from patients with Hutchinson-Gilford progeria syndrome (HGPS) to investigate the relationship between biomechanical stress and inflammation in an organ-on-a-chip device that mimicked the microenvironment of the cardiovascular system. More...
15 Mar 2017
Image: A photomicrograph showing Streptococcus pneumoniae with black carbon (Photo courtesy of the University of Leicester).

Black Carbon Nanoparticles Modify Pathogens and Affect Resistance

Nanoparticles of black carbon, one of the main components of air pollution, have been found to modify the way bacterial pathogens grow in vitro and in vivo and to significantly increase their resistance to treatment with certain antibiotics. More...
14 Mar 2017
Image: A model of an adeno-associated virus containing the DNA coding for the RNA guide, the Cas9 protein derived from Campylobacter jejuni, and the fluorescent reporter protein (GFP). This is possible because of the small size of Cas9 (Photo courtesy of the Institute for Basic Science).

Miniaturized Gene Editing for Treatment of Macular Regeneration

A viral vector was used to insert a very small CRISPR/Cas9 gene-editing tool into mouse muscle cells or retinal pigment epithelium cells, where it induced mutations that partially cured laser damage that mimicked human chronic age-related macular degeneration. More...
10 Mar 2017
Image: A low-temperature scanning electron micrograph (SEM) of a cluster of E. coli bacteria, magnified 10,000 times (Photo courtesy of the USDA).

Genetic Remodeling Transforms E. Coli into Intestinal Pathogen

A team of molecular microbiologists has traced the genetic steps that enable the common bacteria Escherichia coli to transform from a commensal organism into a pathogenic one. More...
09 Mar 2017

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BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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