Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH MEDIA
GLOBETECH PUBLISHING LLC

European Drug Development Project Targets Gram-negative Bacteria

By BiotechDaily International staff writers
Posted on 25 Feb 2014
Image: Microscopic image of gram-negative Pseudomonas aeruginosa bacteria (pink-red rods) (Photo courtesy of Wikimedia Commons).
Image: Microscopic image of gram-negative Pseudomonas aeruginosa bacteria (pink-red rods) (Photo courtesy of Wikimedia Commons).
A consortium of European universities, research institutes, and biopharmaceutical companies has been established to discover and develop novel new antibiotics, especially for treatment of gram-negative bacterial infections.

The ENABLE (European Gram-Negative Antibacterial Engine) project brings together more than 30 European universities and companies, in a six-year program funded by the Innovative Medicines Initiative (Brussels, Belgium), a joint undertaking between the European Union and the pharmaceutical industry association EFPIA (European Federation of Pharmaceutical Industries and Associations – Brussels, Belgium).

The ENABLE project, which is the third within the ND4BB (New Drugs for Bad Bugs) series, spans 13 countries and charges the 32 partners with the mission of establishing a significant antibacterial drug discovery platform for the progression of research programs through discovery and Phase 1 clinical trials.

The primary target of the ENABLE project is gram-negative bacteria. Medically relevant gram-negative bacilli include a multitude of species. Some of them cause primarily respiratory problems (Hemophilus influenzae, Klebsiella pneumoniae, Legionella pneumophila, Pseudomonas aeruginosa), primarily urinary problems (Escherichia coli, Proteus mirabilis, Enterobacter cloacae, Serratia marcescens), and primarily gastrointestinal problems (Helicobacter pylori, Salmonella enteritidis, Salmonella typhi).

One of the several unique characteristics of these bacteria is the structure of the outer membrane. The outer leaflet of the membrane comprises a complex lipopolysaccharide (LPS) whose lipid portion acts as an endotoxin. If LPS enters the circulatory system, it causes a toxic reaction, with the sufferer developing a high temperature, high respiration rate, and low blood pressure. This may lead to endotoxic shock, which can be fatal. This outer membrane protects the bacteria from several antibiotics, dyes, and detergents that would normally damage either the inner membrane or the cell wall's (peptidoglycan). The outer membrane provides these bacteria with resistance to antibacterial agents such as lysozyme and penicillin.

MEDINA (Granada, Spain), one of the participants in the ENABLE project, is an independent nonprofit research and development organization established jointly by the pharmaceutical company Merck Sharp and Dohme, the government of Andalucia, and the University of Granada. Its researchers are actively seeking new molecules from its proprietary natural product libraries to develop new medicines that respond to unmet medical needs.

“MEDINA brings to the project one of the novel antibiotic molecules that will be developed within this partnership. Our participation in this program represents a fantastic opportunity to jointly develop one of our most advanced compounds in our pipeline,” said Dr. Olga Genilloud, scientific director of MEDINA. “MEDINA offers a unique and longstanding expertise in drug discovery. We are committed with the global research effort for the discovery of new antibiotics, as continuity of a long history of success which has resulted in some of the most important breakthrough drugs available to patients today.”

Related Links:

Innovative Medicines Initiative
European Federation of Pharmaceutical Industries and Associations
MEDINA



WATERS CORPORATION

Channels

Genomics/Proteomics

view channel
Image: Exosomes loaded with catalase (shown in red) efficiently interact with neurons (shown in black) to protect them from the effects of Parkinson\'s disease (Photo courtesy of Dr. Elena Batrakova, University of North Carolina).

Exome Delivery of the Anti-Oxidant Catalase Reduces Parkinson's Disease Symptoms in Mouse Model

The exosome delivery of the antioxidant enzyme catalase was shown to dramatically reduce symptoms of Parkinson's disease (PD) in a mouse model. Exosomes are cell-derived vesicles that are present in... Read more

Lab Technologies

view channel
Image: The gene assembly robot, the GeneTheatre (Photo courtesy of Analytik Jena AG).

Genomic Research Laboratories Await New Compact Liquid Handling System

A small footprint benchtop liquid handler that automates multiple gene assembly tasks and associated procedures such as PCR setup is now available for use by biotech and genomic research laboratories.... Read more

Business

view channel

NanoString and MD Anderson Collaborate on Development of Novel Multi-Omic Expression Profiling Assays for Cancer

The University of Texas MD Anderson Cancer Center (Houston, TX, USA) and NanoString Technologies, Inc. (Seattle, WA, USA) will partner on development of a revolutionary new type of assay—simultaneously profiling gene and protein expression, initially aiming to discover and validate biomarker signatures for immuno-oncology... Read more
 

Events

27 May 2015 - 28 May 2015
02 Jun 2015 - 03 Jun 2015
15 Jun 2015 - 18 Jun 2015
Copyright © 2000-2015 Globetech Media. All rights reserved.