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05 Mar 2017 - 09 Mar 2017
20 Mar 2017 - 23 Mar 2017
12 Apr 2017 - 14 Apr 2017

Drug Discovery

Image: A close-up image of a microfluidic chip used to fabricate nanoparticles that could be used to deliver therapeutic genes to specific organs of the body. Colored liquids have been added to highlight the channels (Photo courtesy of Rob Felt, Georgia Institute of Technology).

DNA Labels Simplify Development of Drug Delivery Nanoparticles

A team of biomedical engineers developed a method for labeling potential drug delivery nanoparticles with DNA "barcodes," which allowed the tracing of the nanoparticles within living test animals. More...
21 Feb 2017
Image: Dopamine-making cells in a mouse brain (Photo courtesy of Sung-ung Kang, Johns Hopkins University).

Defects in Newly Identified Molecular Pathway Lead to Parkinson's Disease

A molecular pathway has been traced that protects dopamine producing neurons and prevents Parkinson's disease, and this finding may pave the way for development of drugs to correct defects in this pathway in individuals who have the disease. More...
16 Feb 2017
Image: The crystal structure of the Myc protein in complex with DNA (Photo courtesy of Wikimedia Commons).

Novel Dual-Action Drug Blocks Carcinogenic MYC Oncogene Activity

A novel dual-action, low molecular weight drug suppresses the effects of the MYC cancer gene by blocking the action of two key regulatory proteins. More...
14 Feb 2017
Image: Atorvastatin bound to HMG-CoA reductase (Photo courtesy of Wikimedia Commons).

Statins Slow Growth of Cancers with p53 Structural Mutations

Cancer researchers have demonstrated the ability of cancer-lowering statin drugs to slow the growth of certain types of cancers with p53 mutations. More...
08 Feb 2017
Image: Researchers have synthesized an antisense oligonucleotide (ASO) that can lower tau levels and prevent some neurological damage. In neurons that contain the ASO (above, in red) there are no tau tangles (in green) (Photo courtesy of Dr. Sarah DeVos, Washington University School of Medicine).

Antisense Therapy Lowers Levels of Pathogenic Tau Protein in Models

Antisense therapy was used to reverse the damage caused by accumulation of tau protein in mouse and monkey models of neurodegenerative diseases. More...
08 Feb 2017
Image: Tiny, painless microneedles on a patch can deliver insulin in response to rising glucose levels (Photo courtesy of the ACS).

New Approach to Diabetes Based on Microneedle Smart Patch Insulin Delivery

A novel "microneedle smart patch" has been developed that was designed to automatically correct glucose imbalance in patients with type I or advanced type II diabetes. More...
02 Feb 2017
Image: A ball-and-stick model of the aurintricarboxylic acid (ATA) molecule (Photo courtesy of Wikimedia Commons).

Aurintricarboxylic Acid Proposed as Basis of New Glioblastoma Treatment Plan

The compound aurintricarboxylic acid (ATA) has been identified as a possible new therapeutic agent for treatment of patients with the deadly brain cancer glioblastoma multiforme (GBM). More...
01 Feb 2017

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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