Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH MEDIA
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC

Collaboration for Radiotherapy Microphere Drug Development for the Treatment of Primary and Secondary Liver Cancer

By BiotechDaily International staff writers
Posted on 31 Mar 2014
Sirtex Medical, Ltd. (Sydney, Australia) and Guerbet, SA (Villepinte, France) are entering into a clinical studies collaboration in primary and secondary (metastatic) liver cancer.

The aim of the collaboration is to examine how Sirtex’s SIR-Spheres microspheres and Guerbet’s Lipiodol Ultra Fluid may be combined or sequenced optimally—and additionally developed—for the treatment of patients with hepatocellular carcinoma, metastatic colorectal cancer, metastatic neuroendocrine tumors, and a variety of other primary and secondary liver cancers.

Sirtex’s chief executive officer, Gilman Wong commented that, “Sirtex’s and Guerbet’s shared vision is that one day, rather than being a terminal disease that patients unfortunately die from, liver cancer may be considered a chronic disease that patients can successfully live with. During my time at Sirtex, I have been fortunate to meet a number of patients who have survived their liver cancer for many years following treatment with SIR-Spheres microspheres. We hope through this clinical studies collaboration to make further gains for the benefit of the patients afflicted by liver cancer. Should the initial collaboration prove fruitful, future collaborations in R&D and marketing between our respective companies may be considered.”

Sirtex’s SIR-Spheres microspheres are utilized in selective internal radiation therapy (SIRT), also known as radioembolization, for the treatment of patients with inoperable liver tumors. SIR-Spheres microspheres have been shown in randomized controlled trials (RCTs) to optimize survival in patients with inoperable liver metastases from primary colorectal cancer. SIR-Spheres microspheres are now being assessed in six international, multicenter RCTs in metastatic colorectal cancer (mCRC) and hepatocellular carcinoma (HCC), which cumulatively will enroll over 2,100 patients. The first of these RCTs, the SIRFLOX study, finished patient enrolment in April 2013 and is expected to report its findings in early 2015.

Guerbet’s Lipiodol Ultra Fluid is used in traditional transarterial chemo-embolization (cTACE) procedures for the treatment of patients with inoperable liver tumors. cTACE has been published in over 100 clinical studies. Recently, cTACE has been established as the standard-of-care for the treatment of patients with intermediate stage HCC by three international clinical consensus guidelines in Europe, Japan, and the United States. These consensus guidelines universally recommend cTACE as the standard-of-care for patients with intermediate stage HCC.

Guerbet’s chief executive officer, Yves L’Epine, said, “We are excited about the potential of combining or sequencing our products to improve the efficacy of interventional radiology procedures in patients with unresectable hepatic tumors. Indeed, while Lipiodol and SIR-Spheres individually are well proven and widely used therapies in their own right, they have never been formally evaluated together or sequentially.”

Guerbet is a pharmaceutical group focused on contrast imaging development, offering of contrast products for X-ray and MRI and for interventional radiology, along with a range of injectors and related medical equipment to provide enhanced diagnosis and treatment of patients.

Related Links:

Sirtex Medical
Guerbet 



Channels

Genomics/Proteomics

view channel
Image: Many molecular biology studies begin with purified DNA and RNA extracted from complex environments such as the human gut (Photo courtesy of Los Alamos [US] National Laboratory).

New Metagenomics Analysis Tool Reduces False Discovery Rates

Genomic researchers recently described a novel new tool for analyzing the complex data generated during DNA screens of mixed populations of organisms such as the human gut microbiome. DNA screening... Read more

Drug Discovery

view channel
Image: Wafers like the one shown here are used to create “organ-on-a-chip” devices to model human tissue (Photo courtesy of Dr. Anurag Mathur, University of California, Berkeley).

Human Heart-on-a-Chip Cultures May Replace Animal Models for Drug Development and Safety Screening

Human heart cells growing in an easily monitored silicon chip culture system may one day replace animal-based model systems for drug development and safety screening. Drug discovery and development... Read more

Biochemistry

view channel
Image:  Model depiction of a novel cellular mechanism by which regulation of cryptochromes Cry1 and Cry2 enables coordination of a protective transcriptional response to DNA damage caused by genotoxic stress (Photo courtesy of the journal eLife, March 2015, Papp SJ, Huber AL, et al.).

Two Proteins Critical for Circadian Cycles Protect Cells from Mutations

Scientists have discovered that two proteins critical for maintaining healthy day-night cycles also have an unexpected role in DNA repair and protecting cells against genetic mutations that could lead... Read more

Business

view channel

“Softer” Mass Spec Techniques Gain Advantage in Biomarker Discovery

Two mass spectrometry (MS) technologies, MALDI and DESI, are increasing in applications as their effectiveness is established, according to Kalorama Information (New York, NY, USA) in its report “Proteomics Markets for Research and IVD Applications (Mass Spectrometry, Chromatography, Microarrays, Electrophoresis, Immunoassays,... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.