Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Determining How Low Energy Electrons Damage DNA May Enhance Radiation Protection Strategies

By BiotechDaily International staff writers
Posted on 13 Nov 2013
Print article
A new study by a group of French and Canadian researchers has produced clues into a little-examined but common radiation threat to DNA: low-energy electrons (LEEs), with energies of 0–15 eV.

The scientists have devised the preliminary model of a close DNA cellular environment under threat from LEEs, revealing for the first time their effects on DNA in natural, biologic conditions. Their study was published online August 8, 2013, in the Journal of Chemical Physics.

The investigators’ project is a significant move toward determining how LEEs injure DNA because it provides a realistic research platform for analysis of results. The goal is to use this knowledge to improve current uses of radiation, such as in cancer treatments.

“The way by which these electrons can damage DNA, and how much damage they inflict, quantitatively, is of major importance not only for general radiation protection purposes, but also for improving the efficiency and safety of therapeutic and diagnostic radiation therapy,” said Dr. Michel Fromm, the lead researcher from the Université de Franche-Comté (Besançon, France), whose expertise is in creating nanometer-scaled DNA layers. His co-author of the study is Dr. Leon Sanche, of Sherbrooke University (Sherbrooke, QC, Canada), who is one of the world’s leading authorities on LEE research.

The investigators studied specific features of a small DNA molecule called a plasmid on a specialized thin film they created, which was irradiated by an electron gun. The impact generated transient particles called anions, which dissociate into snippets of DNA. When analyzed, these molecular fragments provide clues into the processes of DNA strand breaks and other DNA injuries that health researchers seek to understand, repair, and prevent.

“The fascinating point is that each time the close environment of DNA changes, new mechanisms of interaction of LEEs appear,” Dr. Fromm said.

Related Links:

Université de Franche-Comté
Sherbrooke University



Print article

Channels

Biochemistry

view channel
Image: A space-filling model of the anticonvulsant drug carbamazepine (Photo courtesy of Wikimedia Commons).

Wastewater May Contaminate Crops with Potentially Dangerous Pharmaceuticals

Reclaimed wastewater used to irrigate crops is contaminated with pharmaceutical residues that can be detected in the urine of those who consumed such produce. Investigators at the Hebrew University... Read more

Lab Technologies

view channel
Image: A 3D nanofiber net formed by the supergelators to trap oil molecules (Photo courtesy of IBN at A*STAR / Institute of Bioengineering and Nanotechnology).

Effective Cleanup with Smart Material That Forms Oil-Trapping Net

Researchers have developed supergelators – an organic oil-scavenging material that rapidly forms a 3D net to trap oil molecules, gelatinizing into solidified masses that can be more easily removed from... Read more

Business

view channel

Collaborative Agreement to Aid in Setting Guidelines for Evaluating Potential Ebola Therapy

Cooperation between an Israeli biopharmaceutical company and medical branches of the US government is designed to set ground rules for continued evaluation of an experimental therapy for Ebola virus disease. RedHill Biopharma Ltd. (Tel Aviv, Israel), a biopharmaceutical company primarily focused on development and c... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.