Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH MEDIA
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC

Determining How Low Energy Electrons Damage DNA May Enhance Radiation Protection Strategies

By BiotechDaily International staff writers
Posted on 13 Nov 2013
A new study by a group of French and Canadian researchers has produced clues into a little-examined but common radiation threat to DNA: low-energy electrons (LEEs), with energies of 0–15 eV.

The scientists have devised the preliminary model of a close DNA cellular environment under threat from LEEs, revealing for the first time their effects on DNA in natural, biologic conditions. Their study was published online August 8, 2013, in the Journal of Chemical Physics.

The investigators’ project is a significant move toward determining how LEEs injure DNA because it provides a realistic research platform for analysis of results. The goal is to use this knowledge to improve current uses of radiation, such as in cancer treatments.

“The way by which these electrons can damage DNA, and how much damage they inflict, quantitatively, is of major importance not only for general radiation protection purposes, but also for improving the efficiency and safety of therapeutic and diagnostic radiation therapy,” said Dr. Michel Fromm, the lead researcher from the Université de Franche-Comté (Besançon, France), whose expertise is in creating nanometer-scaled DNA layers. His co-author of the study is Dr. Leon Sanche, of Sherbrooke University (Sherbrooke, QC, Canada), who is one of the world’s leading authorities on LEE research.

The investigators studied specific features of a small DNA molecule called a plasmid on a specialized thin film they created, which was irradiated by an electron gun. The impact generated transient particles called anions, which dissociate into snippets of DNA. When analyzed, these molecular fragments provide clues into the processes of DNA strand breaks and other DNA injuries that health researchers seek to understand, repair, and prevent.

“The fascinating point is that each time the close environment of DNA changes, new mechanisms of interaction of LEEs appear,” Dr. Fromm said.

Related Links:

Université de Franche-Comté
Sherbrooke University



Channels

Drug Discovery

view channel
Image: Molecular model of the protein Saposin C (Photo courtesy of Wikimedia Commons).

Nanovesicles Kill Human Lung Cancer Cells in Culture and in a Mouse Xenograft Model

Nanovesicles assembled from the protein Saposin C (SapC) and the phospholipid dioleoylphosphatidylserine (DOPS) were shown to be potent inhibitors of lung cancer cells in culture and in a mouse xenograft model.... Read more

Biochemistry

view channel

Possible New Target Found for Treating Brain Inflammation

Scientists have identified an enzyme that produces a class of inflammatory lipid molecules in the brain. Abnormally high levels of these molecules appear to cause a rare inherited eurodegenerative disorder, and that disorder now may be treatable if researchers can develop suitable drug candidates that suppress this enzyme.... Read more

Lab Technologies

view channel
Image: The FLUOVIEW FVMPE-RS Gantry microscope (Photo courtesy of Olympus).

New Multiphoton Laser Scanning Microscope Configurations Expand Research Potential

Two new configurations of a state-of-the-art multiphoton laser scanning microscope extend the usefulness of the instrument for examining rapidly occurring biological events and for obtaining images from... Read more

Business

view channel

Roche Acquires Signature Diagnostics to Advance Translational Research

Roche (Basel, Switzerland) will advance translational research for next generation sequencing (NGS) diagnostics by leveraging the unique expertise of Signature Diagnostics AG (Potsdam, Germany) in biobanks and development of novel NGS diagnostic assays. Signature Diagnostics is a privately held translational oncology... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.