Features | Partner Sites | Information | LinkXpress
Sign In
BioConferenceLive
GLOBETECH PUBLISHING
JIB

Determining How Low Energy Electrons Damage DNA May Enhance Radiation Protection Strategies

By BiotechDaily International staff writers
Posted on 13 Nov 2013
A new study by a group of French and Canadian researchers has produced clues into a little-examined but common radiation threat to DNA: low-energy electrons (LEEs), with energies of 0–15 eV.

The scientists have devised the preliminary model of a close DNA cellular environment under threat from LEEs, revealing for the first time their effects on DNA in natural, biologic conditions. Their study was published online August 8, 2013, in the Journal of Chemical Physics.

The investigators’ project is a significant move toward determining how LEEs injure DNA because it provides a realistic research platform for analysis of results. The goal is to use this knowledge to improve current uses of radiation, such as in cancer treatments.

“The way by which these electrons can damage DNA, and how much damage they inflict, quantitatively, is of major importance not only for general radiation protection purposes, but also for improving the efficiency and safety of therapeutic and diagnostic radiation therapy,” said Dr. Michel Fromm, the lead researcher from the Université de Franche-Comté (Besançon, France), whose expertise is in creating nanometer-scaled DNA layers. His co-author of the study is Dr. Leon Sanche, of Sherbrooke University (Sherbrooke, QC, Canada), who is one of the world’s leading authorities on LEE research.

The investigators studied specific features of a small DNA molecule called a plasmid on a specialized thin film they created, which was irradiated by an electron gun. The impact generated transient particles called anions, which dissociate into snippets of DNA. When analyzed, these molecular fragments provide clues into the processes of DNA strand breaks and other DNA injuries that health researchers seek to understand, repair, and prevent.

“The fascinating point is that each time the close environment of DNA changes, new mechanisms of interaction of LEEs appear,” Dr. Fromm said.

Related Links:

Université de Franche-Comté
Sherbrooke University



comments powered by Disqus

Channels

Drug Discovery

view channel
Image: The European Commission has approved the use of Avastin combined with chemotherapy as a treatment for women with recurrent ovarian cancer (Photo courtesy of Genentech).

Drug for Treatment of Platinum Resistant Recurrent Ovarian Cancer Approved for Use in Europe

For the first time in more than 15 years the European Commission (EC) has approved a new therapeutic option for the most difficult to treat form of ovarian cancer. Ovarian cancer causes more deaths... Read more

Therapeutics

view channel
Image: This type of electronic pacemaker could become obsolete if induction of biological pacemaker cells by gene therapy proves successful (Photo courtesy of Wikimedia Commons).

Gene Therapy Induces Functional Pacemaker Cells in Pig Heart Failure Model

Cardiovascular disease researchers working with a porcine heart failure model have demonstrated the practicality of using gene therapy to replace implanted electronic pacemakers to regulate heartbeat.... Read more

Lab Technologies

view channel
Image: The DrySyn MULTI converts any standard hotplate stirrer into a high performance reaction block (Photo courtesy of Asynt).

New Reaction Vessel Heating System Is Cleaner and Safer

Biotech and other life science researchers can create a safer, cleaner, and more efficient working environment in their laboratories by switching from oil bath-based heating of reaction vessels to a new... Read more

Business

view channel

Global Computational Biology Sector Expected to Reach over USD 4 Billion by 2020

The global market for computational biology is expected to reach USD 4.285 billion by 2020 growing at a compound annual growth rate (CAGR) of 21.1%, according to new market research. Steady surge in the usage and application of computational biology for bioinformatics R&D programs designed for sequencing genomes... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.