Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
PZ HTL SA
GLOBETECH PUBLISHING LLC

Mechanism Discovered for Cancer Cell Metastasis

By BiotechDaily International staff writers
Posted on 18 Jul 2012
Image: Electron microscopy of a tumor cell (blue, green) on the way to extravasate through an alveolar endothelium blood capillary (purple, red). Tumor cell protrusions are seen forming their way through the endothelial cell (Photo courtesy of the University of Zurich.)
Image: Electron microscopy of a tumor cell (blue, green) on the way to extravasate through an alveolar endothelium blood capillary (purple, red). Tumor cell protrusions are seen forming their way through the endothelial cell (Photo courtesy of the University of Zurich.)
Image: Tumor cells (green) adhere on the endothelium (red) that becomes activated and permeable via CCL2-CCR2 signaling. Tumor cell extravasation is facilitated by recruited monocytic cells (blue). Technique: Adaptation of confocal image stacks creating an artificial surface. (Photo courtesy of the University of Zurich.)
Image: Tumor cells (green) adhere on the endothelium (red) that becomes activated and permeable via CCL2-CCR2 signaling. Tumor cell extravasation is facilitated by recruited monocytic cells (blue). Technique: Adaptation of confocal image stacks creating an artificial surface. (Photo courtesy of the University of Zurich.)
Scientists have for the first time discovered a mechanism by which cancer cells metastasize to other parts of the body, where they form the secondary tumors responsible for the vast majority of cancer-related deaths.

Until now, molecular level processes leading to the metastatic spread into certain organs have been unknown, it being unclear as to how the secondary cells are able to leave the bloodstream and enter the tissue of other organs. A European team of physiologists and neuropathologists, primarily through the University of Zurich (Switzerland), have now identified a biochemical pathway underlying the origin of metastasis formation whereby at least some, if not all, types of cancer cells metastasize out of the bloodstream. The team, led by principal investigators Dr. Lubor Borsig and Dr. Mathias Heikenwalder, demonstrated that intestinal cancer cells manipulate specific “doorman receptors” on the endothelium of the blood vessels.

Elevated levels of the chemokine CCL2 are known to be characteristic of metastasizing breast, prostate, and intestinal bowel types of cancer cells; clinically, high CCL2 values have been primarily taken as an indication of strong tumor growth and a poor prognosis. Increased CCL2 expression has also been correlated with recruitment of CCR2+Ly6Chi monocytes, CCR2 being a CCL2-activated receptor. Based on in vivo and in vitro experiments, the current study has now shown CCL2 to be far more than an indicator of the cancer’s aggressiveness – CCL2 was found to be part of a signal transduction mechanism critical in helping at least some types of cancer cells metastasize.

The study describes CCL2 upregulation in metastatic UICC stage IV colon carcinomas and demonstrates that tumor cell-derived CCL2 activates the CCR2+ endothelium and thereby leads to increased vascular permeability in vivo. CCR2 acts as a “doorman receptor” activated by CCL2. The role of the CCR2 doorman in a healthy organism is not known and has only now been detected on the endothelium for the first time. Dr. Borsig suspects that the doorman is involved in modulating the permeability of the blood vessels during the body’s immune response.

“The mechanism discovered will yield a completely new approach for the development of drugs to combat metastasis in breast, prostate, and bowel cancer,” Dr. Borsig is convinced. Suppressing the tumor’s chemokine expression or blocking the doorman specifically for the tumor chemokine to inhibit cancer cells from entering healthy tissue from the bloodstream is conceivable. “If we can succeed in preventing the cancer cells from leaving the bloodstream, the metastasis can be fought directly at the source,” concludes Dr. Borsig.

Related Links:

University of Zurich






SLAS - Society for Laboratory Automation and Screening
RANDOX LABORATORIES
BIOSIGMA S.R.L.
comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: The Human Protein Atlas is tissue-based map of the human proteome (Photo courtesy of the Human Protein Atlas).

Open Source Tissue-Based Map of the Human Proteome Launched

Constructed with 13 million annotated images, an interactive database has been created to show the distribution of proteins in all major tissues and organs of the human body. Ten years after the completion... Read more

Drug Discovery

view channel

Omega 3 Found to Improve Behavior in Children with ADHD

Supplements of the fatty acids omega 3 and 6 can help children and adolescents who have a specific kind of have attention deficit hyperactivity disorder (ADHD). Moreover, these findings indicate that a customized cognitive training program can improve problem behavior in children with ADHD. Statistics show that 3%–6%... Read more

Biochemistry

view channel

Blocking Enzyme Switch Turns Off Tumor Growth in T-Cell Acute Lymphoblastic Leukemia

Researchers recently reported that blocking the action of an enzyme “switch” needed to activate tumor growth is emerging as a practical strategy for treating T-cell acute lymphoblastic leukemia. An estimated 25% of the 500 US adolescents and young adults diagnosed yearly with this aggressive disease fail to respond to... Read more

Lab Technologies

view channel

e-Incubator Technology Provides Real-Time Imaging of Bioengineered Tissues in a Controlled Unit

A new e-incubator, an innovative miniature incubator that is compatible with magnetic resonance imaging (MRI), enables scientists to grow tissue-engineered constructs under a controlled setting and to study their growth and development in real time without risk of contamination or damage. Offering the potential to test... Read more

Business

view channel

Two Industry Partnerships Initiated to Fuel Neuroscience Research

Faster, more complex neural research is now attainable by combining technology from two research companies. Blackrock Microsystems, LLC (Salt Lake City, UT, USA), a developer of neuroscience research equipment, announced partnerships with two neuroscience research firms—PhenoSys, GmbH (Berlin, Germany) and NAN Instruments, Ltd.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.