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First-in-Class Masked Antibody Therapeutic Effective in Fighting Pancreatic Tumor Models

A masked antibody therapeutic has been shown to be effective in fighting pancreatic cancer models as both a single agent and in combination with gemcitabine. More...
13 Nov 2013

Nanocarrier Designed to Target Drug Delivery to Cancer Cells

A novel nanostructure can, because of its dual-surface structure, serve as an improved “all-in-one tool” in the fight against cancer.    More...
13 Nov 2013

Compound Found That Stops Neurodegeneration in Mice

Researchers, who in 2012 identified a key pathway leading to brain cell death in mice, have used an orally administered compound to block that pathway, preventing neurodegeneration in the lab mice. More...
23 Oct 2013
Image: Pluristem PLacental eXpanded (PLX) cell bioreactor (Photo courtesy of Pluristem Therapeutics).

Specialized Stem Cells Demonstrate Efficacy for Graft versus Host Disease Therapy

In a preclinical study, specially grown and expanded stem cells demonstrated efficacy for the treatment of Graft versus Host Disease following bone marrow transplantation in mice. More...
15 Oct 2013

Research Partnership Seeks Compounds to Slow Loss of Motor Neurons in ALS

A research institute is collaborating with a drug discovery company to identify compounds that can prevent or slow down the loss of motor neurons, which is characteristic of the human disease amyotrophic lateral sclerosis. More...
01 Oct 2013
Image: Mark Anderson, MD, PhD, led a team that identified an immune cell, called eTAC cells (shown in green), that may help prevent autoimmune diseases. ETAC cells, which contain a protein in their nucleus called AIRE (shown in red) are relatively rare, and found in lymph nodes and the spleen (Photo courtesy of the University of California, San Francisco (UCSF)).

Discovery Enables Autoimmune Disease Treatment Strategy

Scientists have found a new way to manipulate the immune system that may keep it from attacking the body’s own molecules in autoimmune diseases such as rheumatoid arthritis, type 1 diabetes, and multiple sclerosis. More...
18 Sep 2013
Image: This photomicrograph depicts airway epithelial cells from lung tissue of a COPD patient. The cell nuclei have been stained to reveal IL-33, a type of signaling molecule found at high levels in COPD patients. New research shows that viral infection can induce these cells to proliferate. Release of IL-33 from these cells promotes inflammatory mucus production. These findings provide insight into the mechanisms linking acute infection to chronic inflammatory lung disease (Photo courtesy of Holtzman Lab, Washington University School of Medicine).

Cytokines Induced by Exposure to Airborne Pollutants Drive the Transition from Acute to Chronic Lung Infections

Molecular signaling molecules that link acute viral infections with the development of chronic diseases such as chronic obstructive pulmonary disease have been identified in a mouse model and in human patient samples. More...
28 Aug 2013

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