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Caption: Using a Drosophila fruit fly model to study sugar sensing, researchers have discovered that the transcription factor “cabut” (cbt) represses accumulation of several metabolic targets and provides a regulatory link between nutrient sensing and the circadian clock (Photo courtesy of Bartok O, Mari Teesalu, et al. 2015, and EMBO Journal).

Cabut Coordinates Metabolism and Clock in Response to Nutrient Sensing

Using a Drosophila fruit fly model to study sugar sensing, researchers have discovered that the transcription factor and developmental growth regulator, cabut, coordinates energy metabolism as well as the circadian clock in response to sugar sensing.  More...
01 Jun 2015

Lipoprotein Receptor Mutation Linked to Increased Coronary Heart Disease Risk

A mutation caused by a single nucleotide polymorphism in a cell membrane lipoprotein receptor has been linked to a significantly higher risk for developing coronary heart disease.  More...
01 Jun 2015
Image: Electron micrograph of Hepatitis C virus purified from cell culture. Scale bar is 50 nanometers (Photo courtesy of the Center for the Study of Hepatitis C, the Rockefeller University).

Oxidized LDL Predicts Response to Interferon Treatment of Chronic Hepatitis C and May Be a Treatment Option

Oxidized low-density lipoprotein in the blood was shown to predict responsiveness to interferon treatment in patients with chronic Hepatitis C virus infection and to inhibit spread of the virus in vitro.  More...
27 May 2015
Image: Outer membrane vesicles released by Bacteroides thetaiotaomicron may help initiate inflammatory bowel disease (Photo courtesy of Wandy Beatty, Washington University School of Medicine).

Interaction of Gut Cells with Bacterial Outer Membrane Vesicles Triggers Inflammatory Bowel Disease in Mouse Model

Interaction of bacterial outer membrane vesicles harboring sulfatase activity with the cells lining the gut has been implicated as a key step in the development of inflammatory bowel diseases such as Crohn's disease and ulcerative colitis.  More...
26 May 2015
Image: Micrograph of human intestine from a patient with an inflammatory disease (Photo courtesy of the University of Manchester).

Molecular Modulator of Regulatory T-Cell Behavior Identified

A mechanism has been identified that explains how regulatory T-cells suppress harmful T-cell responses that can lead to the development of autoimmune diseases such as type I diabetes and rheumatoid arthritis.  More...
25 May 2015

Novel Microcapsule Approach Reduces Toxic Side Effects of Chemotherapy

Cancer researchers have reduced chemotherapy's toxic side effects by using nanoporous capsules to transport an enzyme to the site of a tumor where it is activated by a selective heating process to convert a pro-drug into a toxic anticancer agent.   More...
25 May 2015
Image: Mosquitoes are known to infect people and animals with West Nile virus. Studying West Nile virus infection in mice, researchers have shown that the antiviral compound interferon-lambda tightens the blood-brain barrier, making it harder for the virus to invade the brain (Photo courtesy of the CDC – [US] Centers for Disease Control and Prevention).

Interferon-Lambda Prevents West Nile Virus from Crossing the Blood-brain Barrier

The cytokine interferon-lambda prevents West Nile virus from infecting brain cells by reducing transport of large molecules across the blood-brain barrier.  More...
24 May 2015

BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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