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Image: Researchers have generated disease-free stem cells from patients with mitochondrial disease that can be converted into any cell type including neuronal progenitors (left) or heart cells (right). These could potentially be used for future transplantation into patients (Photo courtesy of Salk Institute of Biological Studies).

Methods Developed to Generate Normal Stem Cells from Patients with Mitochondrial Defects

A recent paper described two methods for converting cells from patients with mitochondrial defects into normal pluripotent stem cells that could be induced to differentiate into several different types of tissues.  More...
29 Jul 2015
Image: Nomarski interference contrast photomicrographs of Cryptosporidium in the feces of an HIV-positive human (Photo courtesy of the CDC - [US] Centers for Disease Control and Prevention).

Advanced Genetic Tools Revamp Search for Drugs to Treat Cryptosporidium

Genetically engineered modifications to genome of the diarrhea-causing parasite Cryptosporidium are expected to expedite research towards vaccine and drug development to prevent or cure infection by this pathogen.  More...
28 Jul 2015
Image: Nanoscale artificial antigen presenting cells (nano-aAPCs) bound to receptors on the T-cell surface (Photo courtesy of Dr. Karlo Perica, Johns Hopkins University).

Promising Cancer Immunotherapy Method Relies on Artificial Magnetic Antigen Presenting Cells

Cancer researchers have developed a method based on magnetic nanoparticles that enables the rapid extraction, enrichment, and expansion of a T-cell population that shows great promise as a tool for immunotherapy.  More...
26 Jul 2015
Image: Left: depicts moderate heart disease with limited arterial blockages in the heart of a pig. Right: severe disease with several near-total blockages. The two biomarkers (glycated proteins and oxidized LDL) were greatly elevated only in severe disease (Photo courtesy of the University of North Carolina).

Glycated Proteins and Oxidized Lipoproteins but Not Insulin Resistance Linked to CVD Risk

Heart disease researchers working with a pig model system identified glycated proteins and oxidized low-density lipoproteins as biomarkers for cardiovascular disease risk but did not find a similar association between CVD risk and insulin resistance.  More...
22 Jul 2015
Image: Results presented in this study suggest that the enzyme CD39 can suppress the plaque buildup that may trigger heart attack or stroke (Photo courtesy of the University of Michigan).

Membrane-Bound Enzyme Linked to Plaque Formation in Mouse Atherosclerosis Model

Cardiac disease researchers working with a mouse model of atherosclerosis have found that that a specific membrane bound enzyme has the potential to inhibit build-up of plaque and reduce risk of heart attack or stroke.  More...
21 Jul 2015
Image: The Seraseq Solid Tumor Mutation Mix kit (Photo courtesy of SeraCare).

New Quality Control Reference for Monitoring NGS-Based Tumor Profiling Assays

A newly released kit was designed to enable genomics researchers and drug developers to evaluate the performance of next generation sequencing-based tumor profiling assays.  More...
20 Jul 2015
Image: TEM (transmission electron micrograph) of a mesoporous silica nanoparticle (Photo courtesy of Wikimedia Commons).

Nanoparticle-Delivered siRNA Shrinks Tumors in Mouse Model

Cancer researchers employed a nanoparticle delivery system to deliver short interfering RNA that blocked the activity of Twist-related protein 1, which prevented growth and spread of tumors in a mouse model.  More...
20 Jul 2015

BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.


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