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Genomics/Proteomics

Genetically Engineered Lactobacilli Cure Diabetes in Rat Model

A novel concept for treating diabetes was demonstrated by feeding diabetic rats a diet containing human lactobacilli that had been genetically engineered to secrete the protein glucagon-like peptide-1 GLP-1, which induced significant long-term increases in insulin levels.   More...
09 Feb 2015

Defective Cell Extrusion May Lead to Formation of Tumors in Pancreas, Lungs, or Colon

The disruption of normal S1P2 receptor activity in epithelial cells prevents the pro-apoptotic extrusion of cells from overcrowded tissue and leads to the formation of cancerous growths in the pancreas, lung, and colon.  More...
09 Feb 2015
Image: Researchers reprogrammed human skin cells to create induced pluripotent stem cells, which were then differentiated in a stepwise fashion to create insulin-producing cells. When these cells were transplanted into diabetic mice, the cells secreted insulin and reduced the blood sugar levels of the mice to normal or near-normal levels. The micrograph shows the insulin-producing cells (right) and precursor cells (left) (Photo courtesy of the University of Iowa).

Stem Cell Therapy Cures Diabetes in Mouse Model

Diabetes researchers modified human skin cells to produce insulin and showed that after being injected into diabetic immunodeficient mice, the cells developed into an insulin-producing organoid capable of modulating the animals' glucose metabolism.  More...
08 Feb 2015

Sheffield NHS Lab Moves to Advanced Micorarrays Platform

A case study discusses Sheffield laboratory’s experience of switching to a more efficient and reliable microarrays platform for cytogenetic research.   More...
08 Feb 2015
Image: The micrograph shows the extensive infiltration of robust blood vessels (red) in a new hydrogel scaffold developed to help the healing of internal injuries. The purple cells are pericyte-like cells that surround new endothelial cells, helping to stabilize the vessels. The green cells are circulating through the new vascular system (Photo courtesy of Dr. Vivek Kumar, Rice University).

Upgraded Hydrogel Stimulates Growth of New Blood Vessels for Tissue Regeneration

An upgraded hydrogel for in vivo use as scaffolding for cellular growth incorporates features that overcome most of the limitations that has precluded use of this type of material up to now.  More...
03 Feb 2015
Image: The micrograph depicts a CNP microcapsule. A new treatment delivery method based on CNP microcapsules could reduce inflammation in cartilage affected by osteoarthritis and reverse damage to tissue (Photo courtesy of the Queen Mary University of London).

Time-Release Microcapsules Deliver Anti-Inflammatory Hormone to Repair Cartilage Damaged by Osteoarthritis

Microcapsules loaded with C-type natriuretic peptide have been shown to reduce the type of inflammation characteristic of osteoarthritis in a model system based on the culture of animal cartilage tissue.   More...
03 Feb 2015

KRAS PCR Screening Kit Detects Seven Mutations in a Single Experiment

A research kit designed for use with the latest droplet digital PCR systems is able to detect simultaneously the seven most common KRAS mutations in a single ddPCR experiment.   More...
02 Feb 2015


BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
 

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