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Genomics/Proteomics

Image: A metabolic enzyme has an unexpected role in regulating gene expression in kidney cancer. Primary human kidney tissue: FBP1 protein (green); cell nuclei (blue) (Photo courtesy of the University of Pennsylvania).

Loss of Regulatory Enzyme Spurs Kidney Cancer Growth

Cancer researchers have found that the enzyme fructose-1,6-bisphosphatase 1 is missing or inactive in the clear cell renal cell carcinoma form of kidney cancer, a lack that gives the cancer cells a metabolic advantage over surrounding normal tissue.  More...
31 Jul 2014

Gene Therapy Induces Functional Pacemaker Cells in Pig Heart Failure Model

Cardiovascular disease researchers working with a porcine heart failure model have demonstrated the practicality of using gene therapy to replace implanted electronic pacemakers to regulate heartbeat.  More...
30 Jul 2014
Image: Blocking the activity of HSP101 may imprison the malaria parasite inside its protective vacuole within the red blood cell. In the electron micrograph, the malaria parasites appear in blue and uninfected red blood cells are shown in red (Photo courtesy of the [US] National Institute of Allergy and Infectious Diseases).

Heat Shock Protein Plays Critical Role in Malaria Parasite Protein Trafficking

A pair of recent papers described the molecular operators that enable the malaria parasite Plasmodium falciparum to export a large variety of proteins across the parasitophorous vacuolar membrane within which the parasite resides into the cytoplasm of the infected red blood cell. More...
29 Jul 2014

Molecular Pathway Decreases Cell Adhesion and Initiates Metastasis

A recent paper outlined a molecular pathway that enables lung cancer cells to migrate away from the site of the primary tumor and become established in other parts of the body.  More...
28 Jul 2014
Image: Microcomputed tomography images (top) and histology images (bottom) of the knees of mice fed a very high fat diet containing omega-3 fatty acid supplement (left) or only omega-6 fatty acids (right) after a knee injury. The omega-6 diet showed abnormal bone remodeling and calcified tissue formation in the joint (white arrow). The omega-6 diet also showed significant loss of cartilage (red staining, yellow arrowhead) and increased joint inflammation (Photo courtesy of Duke University).

Dietary Omega-3 Fatty Acids Moderate Severity of Osteoarthritis in a Mouse Model

Researchers working with an osteoarthritis obese mouse model found that the fat content of the animals' diet contributed more to the development or arrest of OA than did body weight. More...
22 Jul 2014

Cinnamon Feeding Blocks Development of Parkinson's Disease in Mouse Model

A team of neurological researchers has identified a molecular mechanism by which cinnamon acts to protect neurons from damage caused by Parkinson's disease (PD) in a mouse model of the syndrome. More...
22 Jul 2014
Image: Scanning electron micrograph of cultured human neuron from induced pluripotent stem cell (Photo courtesy of the University of California, San Diego).

Induced Stem Cells Show Genetic Abnormalities Not Found in Embryonic Stem Cells

All stem cells are not created equal: genomic evaluation revealed that the genome of stem cells generated from adult cells differed considerably from that of "gold standard" human embryonic stem cells.  More...
15 Jul 2014


BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
 
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