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Genomics/Proteomics

Image: Following inhibition of a key protein, these embryonic stem cells underwent differentiation and lost their pluripotency. (Nuclei are in green and nuclei expressing pluripotency factors are in blue and red) (Photo courtesy of Dr. Raffaella Di Micco, New York University Langone Medical Center).

Protein Identified That Maintains Embryonic Stem Cell Pluripotency

A protein that is critical in maintaining stem cells in their primitive pluripotentive state was identified and discussed in a recently published paper.  More...
05 Oct 2014

Chromosome Buffers Improve Understanding of Melanoma

Buffers that guard against damage to the ends of chromosomes could hold the key to a better understanding of malignant melanoma, the deadliest form of skin cancer.  More...
01 Oct 2014
Image: A scheme for the generation of induced pluripotent stem cells (IPSC). (1) Isolate and culture donor cells. (2) Transfect stem cell-associated genes into the cells by viral vectors. Red cells indicate the cells expressing the exogenous genes. (3)  Harvest and culture the cells using mitotically inactivated feeder cells. (4) A small subset of the transfected cells forms iPSC cell colonies (Photo courtesy of Wikimedia Commons).

Innovative Technique Produces More Reliable Pluripotent Stem Cells

A recent paper described a more reliable way to induce the formation of pluripotent stem cells from adult cells in a mouse model.  More...
01 Oct 2014
Image: Electron microscope image of a healthy mouse small intestine showing bacteria (strings) surrounding the gut villi (protrusions). A human small intestine looks very similar (Photo courtesy of the Weizmann Institute of Science).

Artificial Sweeteners May Promote Development of Glucose Intolerance and Weight Gain

Recently published findings have stirred a controversy by indicating that noncaloric artificial sweeteners, a key components of diet drinks and foods, actually promote development of glucose intolerance, metabolic disease, and obesity by causing profound changes in the composition and function of the organisms that make up the intestinal microbiome.  More...
01 Oct 2014
Image: To adhere to catheters and start urinary tract infections, bacteria extend microscopic fibers with sticky proteins at their ends. Researchers have developed a vaccine that blocks the EbpA protein, visible as a white bulge above, and stops infections in mice (Photo courtesy of Dr. John Heuser, Washington University School of Medicine).

Blocking Binding of Bacteria to Fibrinogen Prevents Biofilm Formation and Catheter-Associated Bladder Infection in Mice

A team of molecular microbiologists has identified and targeted a critical step in biofilm formation and developed a vaccine that prevents catheter-associated urinary tract infections in mice.  More...
30 Sep 2014
Image: Illustration of the apoER2 receptor protein shows the structure of the entire protein in detail (Photo courtesy of Wikimedia Commons).

Risk of Cardiovascular Disease Linked to Apolipoprotein E Variants

The apoE4 variant form of circulating apolipoprotein E leads to increased risk of cardiovascular disease by blocking binding of the normal apoE3 form to the apoliprotein E receptor 2 in the membranes of endothelial cells lining the walls of blood vessels and by interacting with the receptor without stimulating production of anti-inflammatory nitric oxide.   More...
29 Sep 2014

MicroRNA Mimic Shown to Reverse Effects of Pulmonary Fibrosis

A potential new treatment that reverses the effects of pulmonary fibrosis, a respiratory disease in which scars develop in the lungs and greatly suppress breathing, is being assessed by scientists.  More...
29 Sep 2014


BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
 
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