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Image: A human nerve cell derived from a patient with Rett syndrome shows significantly decreased levels of KCC2 compared to a control cell (Photo courtesy of Gong Chen laboratory, Pennsylvania State University).

Development of Rett Syndrome Linked to Membrane Transport Protein Deficiency

Neurological disease researchers have found a potential therapeutic approach for the treatment of Rett syndrome that is based on modulation of the calcium transporter protein KCC2.  More...
12 Jan 2016
Image: Representation of a molecule of the Dicer enzyme (Photo courtesy of Wikimedia Commons).

Deleting the Dicer DNA-Repair Enzyme Increases Sensitivity of Cancer Cells to Chemotherapy

Blocking the activity of the enzyme Dicer in rapidly growing cancer cells prevents them from correcting DNA damage, which renders them more sensitive to the action of chemotherapeutic drugs.  More...
12 Jan 2016
Image: Researchers have developed a powerful interactive web application and data set tool to advance understanding of the mutations that lead to and fuel pediatric cancer (Photo courtesy of St. Jude Children\'s Research Hospital).

Internet Application Furthers Pediatric Cancer Research

An interactive web application and dataset that is a powerful tool to advance understanding of oncogenic mutations is available free of charge to pediatric cancer researchers.  More...
11 Jan 2016
Image: Section of a serpentine channel reactor shows the parallel reactor and feeder channels separated by a nanoporous membrane. At left is a single nanopore viewed from the side; at right is a diagram of metabolite exchange across the membrane (Photo courtesy of the Oak Ridge [US] National Laboratory).

Cell-Free Bioreactor Produces Therapeutic Proteins for Point-of-Care Use

A microfluidic bioreactor for cell-free protein synthesis was developed to facilitate the production of a single-dose of a therapeutic protein for point-of-care delivery.  More...
11 Jan 2016
Image: Rolipram activates the brain’s garbage disposal system, eliminating excess tau proteins (glowing red dots) associated with neurodegenerative diseases such as Alzheimer’s disease (Photo courtesy of Columbia University).

Proteasome-Activating Drug Reverses Neurodegenerative Disease Symptoms in Mouse Model

Accumulation of insoluble tau protein complexes, which characterizes several types of neurodegenerative diseases, was associated with a decrease in brain proteasome peptidase activity that could be restored by treatment with a phosphodiesterase-4 inhibitor drug.  More...
06 Jan 2016
Image: Model of the PUMILIO protein family member PUM1 (pumilio RNA binding family member 1) (Photo courtesy of Wikimedia Commons).

Maintenance of a Stable Karyotype Depends on Action of a Long Noncoding RNA

A long noncoding RNA regulates cellular genomic stability by sequestering the PUMILIO proteins, which would otherwise drive chromosomal instability by repressing mitotic, DNA repair, and DNA replication factors.  More...
05 Jan 2016
Image: Left panel: Micrograph of an undifferentiated breast tumor - densely packed with cancerous cells and with a high potential to spread. Right panel: Differentiated tumor following anti-Malat1 ASO treatment with cyst-like cells filled with fluid containing, among other things, milk proteins. Treated tumors were comparatively static with reduced metastatic activity (Photo courtesy of Spector Laboratory, Cold Spring Harbor Laboratory).

Loss of Long Noncoding RNA Inhibits Breast Tumor Metastasis in Mouse Model

Blocking the activity of a single long noncoding RNA in malignant breast cancer mouse models transformed aggressive cancers into slow growing cyst-like tumors and reversed the metastatic process by up to 70%.  More...
05 Jan 2016

BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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