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Genomics/Proteomics

Image: A scanning electron microscope (SEM) micrograph of prostate cancer cells (green) growing in a superporous cryogel with tissue-like elasticity (Photo courtesy of Dr. Bettina Göppert, Karlsruhe Institute of Technology).

In Vitro Three-Dimensional Culture System Enhances Prostate Cancer Cell Growth

A team of cancer researchers developed a three-dimensional in vitro culture system for growing prostate cancer cells in an environment that closely mimics the in vivo tumor microenvironment. More...
07 Jul 2016
Image: Left: a normal mouse muscle mitochondrion. Right: a mitochondrion in mitofusin 2-deficient muscle (Photo courtesy of Dr. D. Sebastian, Institute for Research in Biomedicine, Barcelona).

Loss of Mitochondrial Fusion Enzyme Linked to Age-Related Loss of Muscle Mass

The enzyme mitofusin 2 (Mfn2) was shown to play a key role in the control of age-related muscle mitochondrial damage. More...
06 Jul 2016
Image: HIV-1 viral cores (red) accumulate around the cell nucleus (blue) but remain unable to enter following depletion of the motor protein KIF5B (Photo courtesy of Loyola University Chicago).

HIV Relies on Host Proteins to Clear the Way to the Nucleus

The ability of HIV to transit the cytoplasm and enter the nucleus of an infected cell was found to depend on the combined activities of two host proteins, the Kinesin-1 motor protein, KIF5B, and the nuclear pore component Nup358. More...
06 Jul 2016
Image: The Zika virus infecting cells: Zika virus (red) infects cultured human cells (blue, left panel). Zika virus replication is inhibited (right panel) when endoplasmic reticulum membrane complex levels in the human cells are lowered (Photo courtesy of the University of Massachusetts Medical School).

Genome Screen Identifies Host Proteins Required for Flavivirus Infection

A team of molecular virologists employed advanced genome editing techniques to identify the host proteins required by flaviviruses such as dengue and Zika for infection and replication. More...
05 Jul 2016
Image: A model of the three-dimensional structure of the Zika virus envelope protein (red, yellow and blue) in complex with the neutralizing antibody (in green and white) (Photo courtesy of the Institut Pasteur).

Crystal Structure Determined for Binding Site of Zika/Dengue Neutralizing Antibodies

An international team of molecular virologists has identified neutralizing antibodies that bind to and block both dengue virus and Zika virus, which may pave the way for development of a vaccine to protect against both viruses simultaneously. More...
05 Jul 2016
Image: An artist\'s impression of bioprinting in action, a rapidly emerging technique for the building of living 3D tissue constructs (Photo courtesy of the University of Bristol).

Three-Dimensional Printing of Living Tissues with Stem Cell Bioink

A recent paper described an advance in the use of three-dimensional printing that enables the use of the technique to print living tissues from a bioink that contains stem cells and nutrients. More...
05 Jul 2016
Image: The figure depicts the X-ray crystal structure of the serine protease urokinase-type plasminogen activator (green) in complex with a Camelid antibody fragment (orange). The Camelid antibody fragment (nanobody) displays an unusual inhibitory mechanism by binding to the active site region (highlighted in blue) of the serine protease where it mimics the binding of substrate (Photo courtesy of Dr. Tobias-Kromann-Hansen, Aarhus University).

Nanobodies Facilitate Studies of Enzyme Substrate Interactions

The unusual crystal structure of a nanobody in complex with a serine protease enzyme was established by X-ray crystallography. More...
29 Jun 2016


BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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