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Genomics/Proteomics

Image: A skin biopsy with melanoma present (Photo courtesy of Wikimedia Commons).

New Insights Regarding the Genetic Factors that Drive Melanoma Development

Cancer researchers have linked both active and inactive forms of the protein ATF2 (Activating transcription factor 2) to the development and progression of malignant melanoma. More...
09 Jun 2016
Image: The structure of the Isg15 protein (Photo courtesy of Wikimedia Commons).

Lack of Gene that Protects Mice Promotes Anti-Viral Immunity in Humans

Researchers have resolved the question of why a gene that plays an important role in protecting mice from viral infection does not have a similar role in humans. More...
08 Jun 2016
Image: Lab-engineered human capillaries (in green) derived from stem cells are \"making contact\" with the sprouts protruding from a rat aorta (in red) (Photo courtesy of Tiago Fortunato, University of Bath).

3D Culture on Lysate Gel Scaffolds Prompt Microvascular Network Formation

Use of human platelet lysate gel as the support material for the three-dimensional culture of endothelial progenitor cells (EPCs) enables the formation of a complete microvascular network in vitro. More...
08 Jun 2016
Image: A human breast cell lacking HOXA5 (right) shows protruding structures similar to tumor cells, compared with a normal human breast cell (left) (Photo courtesy of Dr. Sara Sukumar, Johns Hopkins University).

Study Shows HOXA5 Impedes Breast Cancer Tumor Initiation and Progression

A team of cancer researchers has discovered that the HOXA5 (Homeobox protein Hox-A5) gene, which is not found in many breast cancers, acts as a tumor suppressor by regulating E-cadherin and CD24. More...
07 Jun 2016
Image: The structure of the ubiquitin-binding protein p62 (Photo courtesy of Wikimedia Commons).

Study Links p62 Protein to Likelihood of Liver Cancer Recurrence

Cancer researchers have linked levels of the ubiquitin-binding autophagy receptor protein p62 (Sequestosome-1) in liver cells to the development and recurrence of hepatocellular carcinomas (HCCs). More...
06 Jun 2016
Image: Electroporation jolts embryos with electricity to open holes that allow the CRISPR-Cas9 molecule (lower right) to enter and edit the DNA (Photo courtesy of Dr. Andrew Modzelewski, Dr. Lin He, University of California, Berkeley).

Rapid Injection Technique Improves Production of Genetically Engineered Mice

An electroporation method has been introduced that improves the production of genetically altered "knock-out" mice by requiring less time and being more efficient at introducing the CRISPR-Cas9 genome editing complex than is the current microinjection method. More...
06 Jun 2016
Image: An artist\'s rendition of the chromatin-nucleosome complex composed of DNA and histones. Polycomb-group proteins can remodel chromatin such that epigenetic silencing of genes takes place (Photo courtesy of Wikimedia Commons).

Mouse Model Advances Drug Development for Treating Lymphoma and Melanoma

Cancer researchers have established a mouse model system to study the involvement of EZH2 histone methyltransferase (EZH2) mutations in the development of lymphoma and melanoma tumors. More...
02 Jun 2016


BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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