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Image: As seen through a microscope, the leg bone of a normal mouse (left) makes considerably less new bone than a mouse that produces high levels of a signaling protein, WNT7B, that stimulates new bone growth (shown in pink on the right). The protein could become a target for new drugs to treat osteoporosis and other conditions related to bone loss (Photo courtesy of Washington University School of Medicine).

Generation of New Bone Depends on WNT Stimulation of the mTORC1 Pathway

The WNT signaling protein WNT7B potently enhances formation of new bone through activation of mTORC1 in a mouse osteoporosis model.  More...
18 Feb 2014
Image: A diorama at the Neanderthal museum in Croatia. A substantial fraction of the Neanderthal genome persists in modern human populations. A new approach applied to analyzing whole-genome sequencing data from 665 people from Europe and East Asia shows that more than 20% of the Neanderthal genome survives in the DNA of this contemporary group, whose genetic information is part of the 1000 Genomes Project (Photo courtesy of Max Planck Institute).

Sizeable Neanderthal Genome Still Exists in Modern Humans

A new strategy for analyzing whole-genome sequencing data from 665 people from Europe and East Asia revealed that more than 20% of the Neanderthal genome survives in the DNA of this contemporary group.  More...
18 Feb 2014
Image: The external face of the Flavivirus NS1 protein (sugars in grey balls) is exposed on infected cell surfaces where it can interact with the immune system. This face is also exposed in secreted NS1 particles present in patient sera. The background image shows artificial membranes coated with the NS1 protein (Photo courtesy of the University of Michigan).

X-Ray Crystallography Reveals the Two Faces of Flavivirus Nonstructural Protein

High-resolution X-ray crystallography and electron microscopy have revealed that the Flavivirus NS1 has two distinct faces, one that interacts with the interior of the infected host cell and the other that is exposed to antiviral elements in the host's immune system.  More...
17 Feb 2014

New Tool Developed to Identify Genetic Risk Factors

A new biological pathway-based computational model has been developed to identify underlying genetic connections between different diseases.  More...
13 Feb 2014
Image: An artist's rendition of a Lentivirus expression vehicle (Photo courtesy of AMS Biotechnology ).

MicroRNA Studies to Be Enhanced by a New Line of Anti-miRNA Tools

A novel line of ready-to-use lentiviral expression vehicles provides microRNAs and miRNA inhibitors for use as tools for the study of miRNAs and their role in various disease processes.   More...
13 Feb 2014
Image: Shown here is a tumor that metastasized from its original site in the prostate to the lung. Researchers were surprised to find the Myc protein in these tumors and, through further experiments, discovered that simply increasing the amount of Myc in the cell was enough to drive metastasis, suggesting a druggable target for metastatic prostate cancer (Photo courtesy of Cold Spring Harbor Laboratory).

The MYC Oncogene Initiates and Maintains Metastasis in Mouse Prostate Cancer Model

A mouse metastatic prostate cancer model is expected to enable researchers to better investigate the causes of the disease while at the same time test new therapeutics to treat it.  More...
12 Feb 2014

Experimental Drug Reduces Brain Inflammation in Diabetic Rat Model

A recent paper reported that peptides that mimic the activity of thioredoxin were able to inhibit the development of inflammation in the brains of Zucker diabetic fatty rats.  More...
11 Feb 2014

BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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