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Image: Replicating human beta cells. In cells where p57 was successfully inhibited, beta cells could undergo DNA replication. Pink: nucleus that has undergone DNA replication. Green: Insulin. Blue: Nuclei counterstained for DNA. White: p57 (Photo courtesy of Dr. Klaus Kaestner, University of Pennsylvania).

Blocking a Cell Cycle Inhibitor Stimulates Replication of Insulin-Producing Beta Cells

Diabetes researchers have found that they could stimulate replication of mature pancreatic beta cells by blocking the activity of the cell cycle inhibitor protein p57Kip2.  More...
27 Jan 2014

Nanoparticle Co-Delivery of a Membrane-Associated Protein and a Small-Molecule Anticancer Drug Enhanced Therapeutic Efficacy in a Mouse Model

Combining two anticancer drugs within a novel targeted nanoparticle overcomes their shortcomings and forms the basis for a new therapeutic agent with improved inhibition of tumor growth in a mouse xenograft- tumor model.   More...
23 Jan 2014

Luteolin Nanocapsules Demonstrate Effective Anticancer Activity in Mouse Model

Nanocapsules containing the natural antioxidant luteolin were found to be significantly more effective than natural luteolin in inhibiting growth of cancer cells both in culture and in a mouse xenograft model.  More...
23 Jan 2014

Growth and Spread of Ovarian Cancer Mediated by a Specific MicroRNA

Cancer researchers have linked the gene silencing activity of a specific microRNA to TGF-beta-mediated molecular pathways that support the growth and spread of ovarian cancer.  More...
22 Jan 2014
Image: Three-dimensional molecular space-fill model of tetrabenazine (TBZ) (Photo courtesy of Wikimedia Commons).

Results of Mutagenesis Study Expected to Guide Development of Drugs for Nervous System Disorders

A mutagenesis study utilizing a human gene expressed by yeast cells has yielded new insights into the molecular mechanism controlling binding of neurotransmitters in the brain.  More...
21 Jan 2014
Image: Scanning electron micrograph of a melanoma cell. BRAF fusion genes in pan-negative melanomas may render them sensitive to MEK inhibitors (Photo courtesy of Vanderbilt University).

Gene Fusions Make Some Pan-Negative Melanomas Sensitive to MEK Inhibitors

Cancer researchers have identified a class of fusion genes that drive melanoma metastasis in the 35% of these skin cancers that lack the previously known driver mutations.  More...
16 Jan 2014

Blocking RON Shuts Down Breast Cancer Metastasis

A recent paper suggested that initiation of breast cancer metastasis did not depend on a specific genetic mutation but rather on improper regulation of molecular pathways that control activation and inactivation of certain critical genes.  More...
16 Jan 2014

BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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