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Image: A photomicrograph showing T-cells (red) and tumor cells (green) incubated with control particles (left) or immunoswitch particles (right). The T-cells that have attached to tumor cells are indicated by green arrows (Photo courtesy of Alyssa Kosmides, Johns Hopkins University).

Bifunctional Nanoparticles Show Potential in Cancer Models

To be successful, an immunotherapeutic approach for treating cancer must overcome the immunosuppressive effects of the tumor microenvironment; a novel bifunctional nanoparticle does just that. More...
19 Jun 2017
Image: Three-dimensional (3D)-printed cartilage constructs growing in tissue culture (Photo courtesy of the University of Gothenburg).

Stem Cell and 3D Printing Generate Viable Tissue

A team of Swedish cell biologists combined three-dimensional (3D) bio-printing with advanced stem cell technology to create viable cultures of cartilage tissue that had cellular and mechanical properties similar to patients’ natural cartilage. More...
11 May 2017
Image: Using CRISPR technology, researchers rewired stem cells to produce an anti-inflammatory arthritis drug for when the cells encounter inflammation (Photo courtesy of Ella Marushchenko).

Modified Stem Cells Used to Correct Arthritis Inflammation

Researchers have used CRISPR/Cas9 genome editing technology to create mouse stem cells able to infiltrate the joints, form cartilage tissue, and correct the autoimmune defects that are responsible for arthritis. More...
10 May 2017
Image: A confocal micrograph of mouse retina depicting optic fiber layer (Photo courtesy of the National Center for Microscopy and Imaging Research, University of California, San Diego).

Gene Editing Restores Vision in Mouse RP Models

The CRISPR/Cas9 gene-editing tool was used to reprogram defective optical rod photoreceptor cells and transform them into functioning cone photoreceptors, which restored impaired vision in two mouse models of retinitis pigmentosa. More...
04 May 2017
Image: A model of an adeno-associated virus containing the DNA coding for the RNA guide, the Cas9 protein derived from Campylobacter jejuni, and the fluorescent reporter protein (GFP). This is possible because of the small size of Cas9 (Photo courtesy of the Institute for Basic Science).

Miniaturized Gene Editing for Treatment of Macular Regeneration

A viral vector was used to insert a very small CRISPR/Cas9 gene-editing tool into mouse muscle cells or retinal pigment epithelium cells, where it induced mutations that partially cured laser damage that mimicked human chronic age-related macular degeneration. More...
10 Mar 2017
Image: A new study has shown a link between idiopathic pulmonary fibrosis (IPF) and aging (Photo courtesy of Thinkstock).

Link Between Aging and Fibrotic Pulmonary Disease Discovered

A study analyzing transcriptome biomarker data has shown evidence linking cellular senescence with idiopathic pulmonary fibrosis (IPF), suggesting that this fatal lung disease maybe involve a form of accelerated aging. More...
09 Mar 2017
Image: A novel in vitro culture method enables disease fighting immune T-cells to overcome cancer\'s immunosuppressive effect (Photo courtesy of the Mayo Clinic).

Novel Culture Method for Activation of Cancer-Fighting T-Cells

A novel in vitro culture method enables disease fighting immune T-cells to overcome cancer's immunosuppressive effect in order to recognize and attack tumor cells upon being returned to the body. More...
02 Mar 2017
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