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Therapeutics

Image: An artist\'s rendition of a fluorescence microscope image of the artificial beta cells (Photo courtesy of Gu Laboratory, University of North Carolina).

Novel Approach for Treating Diabetes Based on Artificial Beta Cells

A possible long-term approach for treating diabetes could be based on a novel type of artificial pancreatic beta cells capable of releasing insulin in response to elevated levels of glucose. More...
14 Nov 2017
Image: In this reconstituted schematic, hematopoietic stem cells (HSC) transplanted in a mouse model of Friedreich\'s ataxia differentiate into microglial cells (red) and transfer mitochondrial protein (green) to neurons (blue), preventing neurodegeneration (Photo courtesy of Dr. Stephanie Cherqui, University of California, San Diego).

Stem Cell Therapy Cures Friedreich's Ataxia in Mouse Model

Stem cell therapy was used to cure Friedreich's ataxia in a mouse model of the fatal degenerative disease. More...
09 Nov 2017
Image: Researchers have found that magnetic nanoparticles could be appropriate for use in self-regulating hyperthermia therapeutics (Photo courtesy of iStock).

Novel Ferrite Nanoparticles for Hyperthermic Cancer Therapeutics

A novel type of nontoxic magnetic nanoparticles shows potential for treating malignant tumor cells through controlled hyperthermia. More...
08 Nov 2017
Image: A photomicrograph of a liver biopsy from a patient with alpha-1 antitrypsin deficiency. The PAS with diastase stain shows the diastase-resistant pink globules that are characteristic of this disease (Photo courtesy of Wikimedia Commons).

Diseased Liver Model Facilitates Search for AAT Deficiency Cure

Researchers have developed a new humanized liver mouse model with the mutation that causes alpha-1 antitrypsin deficiency in order to determine whether it is possible to cure the disease by repopulating the defective liver with gene edited healthy cells. More...
02 Nov 2017
Image: Researchers have found MS can be inhibited or reversed using a novel gene therapy technique that stops the disease’s immune response in mouse models (Photo courtesy of the University of Florida Health).

Gene Therapy Targets Liver in Mouse MS Study

Results of studies carried out on a mouse model of multiple sclerosis (MS) demonstrated the potential of a novel potent and long-lasting gene immunotherapy approach for preventing and treating the disease. More...
02 Oct 2017
Image: Zika virus (green) preferentially targets the stem cells (red) in a human glioblastoma (Photo courtesy of Zhu et al., 2017).

Oncolytic Therapy Cures Glioblastoma in Model

Results of experiments conducted using a mouse glioblastoma model suggest that treatment with Zika virus could be used to treat this aggressive and usual fatal disease. More...
19 Sep 2017
Image: A diagram of a scaffold loaded with CAR T-cells and “microspheres” containing nutrients to help the cells multiply and then leave the scaffold to go attack cancer cells (Photo courtesy of the Fred Hutchinson Cancer Research Center).

Nanoparticle Reagent Simplifies Gene Expression Programming

Novel nanoparticle carriers were used to deliver mRNA directly to specific cell types (T-cells of the immune system and blood stem cells) in order to induce short-term changes in gene expression that could be harnessed to treat diseases ranging from cancer to diabetes. More...
13 Sep 2017
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BioResearch Therapeutics channel deals with all aspects of therapies beyond the five-year horizon.
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