Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Study Shows Curcumin Kills Childhood Neuroblastoma Cells

By BiotechDaily International staff writers
Posted on 08 Aug 2017
Print article
Image: Curcumin, a component of the common spice turmeric, could be the key to killing treatment-resistant neuroblastoma tumor cells (Photo courtesy of iStock).
Image: Curcumin, a component of the common spice turmeric, could be the key to killing treatment-resistant neuroblastoma tumor cells (Photo courtesy of iStock).
Treatment-resistant human childhood neuroblastoma tumor cells growing in culture were targeted and destroyed by the natural anti-cancer agent curcumin, which had been delivered to the cells via a novel class of cerium oxide nanoparticles.

Neuroblastomas are cancers that start in early nerve cells and commonly form in the tissue of the adrenal glands, near the kidneys with most cases appearing in children younger than five years old. High-risk neuroblastoma is difficult to treat and frequently develops resistance to standard therapies or recurs.

Investigators at the University of Central Florida (Orlando, USA) synthesized various formulations of nanoceria (cerium oxide nanoparticles) and dextran-coated nanoceria loaded with curcumin. Curcumin is known to have substantial anti-cancer properties, but its low solubility and poor stability have reduced its usefulness in medicinal applications.

In the current study, the anti-cancer activities of the nanoparticle formulations were explored in neuroblastoma models of both MYCN (N-myc proto-oncogene protein)-amplified and non-amplified cell lines. Amplification and overexpression of N-Myc can lead to tumorigenesis. Excess N-Myc is associated with a variety of tumors, most notably neuroblastomas where patients with amplification of the N-Myc gene tend to have poor outcomes.
Results published in the June 9, 2017, online edition of the journal Nanoscale revealed that ceria nanoparticles, coated with dextran and loaded with curcumin, induced substantial cell death in neuroblastoma cells while producing no or only minor toxicity in healthy cells. This formulation evoked prolonged oxidative stress and induced caspase-dependent apoptosis. Overall, nano-therapeutic treatments showed a more pronounced effect in MYCN-amplified cells, which are traditionally more resistant to drug therapies.

"This shows that nanoparticles can be an effective delivery vehicle for cancer drugs," said senior author Dr. Sudipta Seal, professor of materials science at the University of Central Florida. "More research is needed, but we are hopeful it could lead to more effective treatment of this devastating disease in the future."

Related Links:
University of Central Florida


Print article

Channels

Biochemistry

view channel
Image: A space-filling model of the anticonvulsant drug carbamazepine (Photo courtesy of Wikimedia Commons).

Wastewater May Contaminate Crops with Potentially Dangerous Pharmaceuticals

Reclaimed wastewater used to irrigate crops is contaminated with pharmaceutical residues that can be detected in the urine of those who consumed such produce. Investigators at the Hebrew University... Read more

Business

view channel

Collaborative Agreement to Aid in Setting Guidelines for Evaluating Potential Ebola Therapy

Cooperation between an Israeli biopharmaceutical company and medical branches of the US government is designed to set ground rules for continued evaluation of an experimental therapy for Ebola virus disease. RedHill Biopharma Ltd. (Tel Aviv, Israel), a biopharmaceutical company primarily focused on development and c... Read more
Copyright © 2000-2017 Globetech Media. All rights reserved.