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Genomics/Proteomics

Image: Organoids created from the bladder cancers of patients mimic the characteristics of each patient\'s tumor and may be used in the future to identify the best treatment for each patient (Photo courtesy of Columbia University Medical Center).

Bladder Cancer Organoids May Lead to Treatment Breakthrough

Cancer researchers have established a "bio-bank" of patient-derived organoid lines that recapitulates the histopathological and molecular diversity of human bladder cancer. More...
19 Apr 2018
Image: A micrograph of the West Nile virus (shown in yellow) (Photo courtesy of Wikimedia Commons).

Vaccine Cures and Protects against West Nile Virus

Treatment with a novel siRNA-based vaccine offered efficient late-stage therapy and facilitated development of natural long-term immunity against West Nile virus in a mouse model system. More...
18 Apr 2018
Image: New possible health benefits have been linked to the anthocyanidin family of berry pigments, which includes wild bilberries (Photo courtesy of Shutterstock).

Finnish Study Describes Activators of SIRT6 Gene

A team of Finnish researchers conducted a study to evaluate the differences in chemical features between inhibitors and activators of the cancer-related SIRT6 gene. More...
17 Apr 2018
Image: Calcium phosphate mineralization occurs in both extra- and intrafibrillar spaces of collagen (left and right images, respectively). The confined collagen structure contributes to reducing the thermodynamic energy barrier to intrafibrillar nucleation for bone mineralization (Photo courtesy of Washington University).

Nano-Imaging Reveals Links to Regulation of Bone Mineralization

A team of bioengineers applied a hi-tech nano-imagining technique to determine the mechanisms involved in the initialization and regulation of the process of bone mineralization. More...
16 Apr 2018
Image: Malik et al conducted a multi-ancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32 (Photo courtesy of Gerd Altmann).

Stroke Genetics Study Triples Number of Known Risk Loci

Results of one of the largest genome-wide-association studies (GWAS) to be carried out on stroke revealed 22 new stroke risk loci, bringing the total to 32, which more than triples the number of gene regions known to affect stroke risk. More...
11 Apr 2018
Image: Genetically modified astrocytes (red) line the lesion border in the injured spinal cord. A new mouse study showed that triggering a gene inside astrocytes activated the star-shaped cells and may improve the brain’s ability to heal from a range of debilitating conditions, from stroke to concussions and spine injuries (Photo courtesy of Dr. Meifan Amy Chen, University of Texas Southwestern Medical Center).

Critical Brain Cell Repair Gene Identified in Study

Repair of damaged brain cells depends on the process of astrogliosis, which has been shown to be regulated by the MAP3K13 (also known as leucine zipper-bearing kinase [LZK]) gene. More...
10 Apr 2018
Image: Antibodies against APOE (red) bind to amyloid plaques (blue) in brain tissue from people with Alzheimer\'s disease. Investigators have found that the antibody can sweep away the damaging plaques, at least in mice, which could lead to a therapy for the devastating disease (Photo courtesy of Monica Xiong, Washington University School of Medicine).

Antibody Clears Amyloid Plaques in Mouse Model

A team of Alzheimer's disease researchers working with a mouse model identified a specific antibody capable of binding to and mediating the removal of the amyloid plaques that characterize this catastrophic neurodegenerative disorder. More...
10 Apr 2018


BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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