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Genomics/Proteomics

Image: Compared to a control (left), a soluble version of TLR5 (right) reduced the formation of amyloid plaques (brown) in the brains of mice that produced large amounts of human beta-amyloid (Photo courtesy of Chakrabarty et al., 2018).

Vaccination with Receptor Protein Protects Mice against AD

A soluble version of a protein involved in the formation of toxic amyloid plaques was shown to prevent aggregation of amyloid beta (Abeta) and slow development of Alzheimer's disease (AD) in a mouse model. More...
12 Sep 2018
Image: A photomicrograph of the Gram-positive bacterium, Propionibacterium acnes growing in thioglycollate medium. P. acnes bacteria, which normally reside in the sebaceous glands of the skin, are responsible for acne vulgaris, or pimples (Photo courtesy of the [U.S.] Centers for Disease Control and Prevention).

Early Stages Proceed in Development of Acne Vaccine

A potential vaccine to protect against development of acne is based on a virulence factor isolated from the bacteria that causes the severe skin inflammation. More...
11 Sep 2018
Image: In a recent study, CRISPR gene editing was shown to halt the progression of Duchenne muscular dystrophy (DMD) in dogs. The photomicrographs show dystrophin (in green) in a healthy diaphragm muscle (left), absence of dystrophin in a dog with DMD (center), and restoration of dystrophin in dogs treated with CRISPR (right) (Photo courtesy of the University of Texas Southwestern Medical Center).

Gene Editing Reverses DMD Muscle Damage in Model

The CRISPR/Cas9 genome-editing tool was used in a proof-of-concept study conducted in dogs suggested that the technique could be clinically useful for the treatment of Duchenne muscular dystrophy. More...
10 Sep 2018
Image: The role of miRNAs in inflammatory bowel disease (IBD): miR-29 loaded on a supercarbonate apatite prevented the development of inflammation by suppressing the production of inflammatory cytokines (IL-6, TGF-beta, and IL-23) secreted from dendritic cells and by suppressing the differentiation of naive T-cells to Th17 cells (Photo courtesy of Osaka University).

Nucleic Acid Therapy Effective in Inflammatory Bowel Disease Model

A team of Japanese researchers working with a mouse model recently described a novel method for using microRNAs to treat inflammatory bowel disease (IBD). More...
06 Sep 2018
Image: A photomicrograph showing Zika virus particles in red, within the endomembrane system of African green monkey kidney cells (Photo courtesy of the U.S. National Institute of Allergy and Infectious Diseases).

Map Reveals How Zika Virus Associates with Host Cell Proteins

A team of viral molecular biologists has mapped host cell protein interaction profiles for each of the ten polypeptides encoded in the Zika virus (ZIKV) genome, generating a protein topology network comprising 3033 interactions amongst 1224 unique human polypeptides. More...
05 Sep 2018
Image: A micrograph of a pleural fluid cytopathology specimen showing mesothelioma (Photo courtesy of Wikimedia Commons).

Polysome Screen Identifies Cancer Related MicroRNAs

An international research team has developed a polysome-based method for detecting microRNAs (miRNAs) that act to promote or sustain growth of malignant mesothelioma and other types of cancer. More...
04 Sep 2018
Image: Mice fed a diet high in trans fats and cholesterol for 12 weeks show fatty deposits in the liver (red staining) (Photo courtesy of Dr. Brian DeBosch, Washington University School of Medicine).

Blocking Glucose Metabolism Prevents Development of Metabolic Syndrome

A novel approach to preventing diabetes and other manifestations of metabolic syndrome, which includes obesity, diabetes, and fatty liver disease, showed promising results in mouse model systems. More...
03 Sep 2018


BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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