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Genomics/Proteomics

Image: The water flea Daphnia pulex, source of the MfR protein subunits Met and SRC (Photo courtesy of Wikimedia Commons).

Alternative Technique Developed for Toxicity Screening

An innovative high-throughput screening technique is expected to improve drug development strategies by greatly reducing the time required to identify the potential for expression of toxic side effects. More...
20 Sep 2017
Image: Zika virus (green) preferentially targets the stem cells (red) in a human glioblastoma (Photo courtesy of Zhu et al., 2017).

Oncolytic Therapy Cures Glioblastoma in Model

Results of experiments conducted using a mouse glioblastoma model suggest that treatment with Zika virus could be used to treat this aggressive and usual fatal disease. More...
19 Sep 2017
Image: New research clarifies the relationship between two genes that fuel the aggressive spread of neuroblastomas (Photo courtesy of the Mayo Clinic).

Zebra Fish Model Yields Clues to Neuroblastoma Growth

A genome-wide association study (GWAS) conducted in a zebra fish model system identified LMO1, which encodes a LIM-domain-only transcriptional cofactor, as a neuroblastoma susceptibility gene that functions as an oncogene in high-risk neuroblastoma. More...
15 Sep 2017
Image: A photomicrograph of the pathogenic bacterium Mycobacterium avium (Photo courtesy of Wikimedia Commons).

Mycobacteria Use Voltage-Dependent Channels to Prevent Destruction

A team of molecular microbiologists unraveled the mechanism whereby the pathogenic bacterium Mycobacterium avium modifies the environment inside the macrophage phagosome and transforms it from a killing site to place for growth and reproduction. More...
14 Sep 2017
Image: A diagram of a scaffold loaded with CAR T-cells and “microspheres” containing nutrients to help the cells multiply and then leave the scaffold to go attack cancer cells (Photo courtesy of the Fred Hutchinson Cancer Research Center).

Nanoparticle Reagent Simplifies Gene Expression Programming

Novel nanoparticle carriers were used to deliver mRNA directly to specific cell types (T-cells of the immune system and blood stem cells) in order to induce short-term changes in gene expression that could be harnessed to treat diseases ranging from cancer to diabetes. More...
13 Sep 2017
Image: A ribbon model of the beta-2 adrenergic receptor (Photo courtesy of Wikimedia Commons).

Depressing Stress Signaling Increases Immune Activity

Cancer researchers evaluating the immune status of the tumor microenvironment found that CD8+ T-cell frequency and functional orientation were regulated by beta-2-adrenergic receptor (beta-AR) signaling and suggested using clinically available beta-blockers in patients to improve responses to immunotherapy. More...
12 Sep 2017
Image: A scanning electron micrograph (SEM) of an ovarian cancer cell (Photo courtesy of Steve Gschmeissner / SPL).

Lack of Correlation in Cancer Cells May Complicate Drug Development

Cancer researchers have are warning drug developers that in about 62% of ovarian cancer cell samples levels of messenger RNA and protein did not accurately reflect changes in gene activity. More...
07 Sep 2017
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BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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