Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Normal Skin Resists and Rejects Cancerous Growth

By BiotechDaily International staff writers
Posted on 14 Aug 2017
Print article
Image: Research shows normal cells help corral tumors (left) and when removed lead to expansion of cancers (Photo courtesy of Yale University).
Image: Research shows normal cells help corral tumors (left) and when removed lead to expansion of cancers (Photo courtesy of Yale University).
While examining the biological effects that emerge from interactions between cancerous cells and neighboring normal skin cells, cancer researchers demonstrated the ability of the skin to eliminate the mutant cells.

Investigators at Yale University (New Haven, CT, USA) were particularly keen to understand how tissue in the near vicinity of a tumor remains phenotypically normal, despite the presence of these mutant cells.

To unravel this puzzle, the investigators used advanced imaging techniques to track the fate of mouse skin epithelium burdened with varying numbers of activated Wnt/beta-catenin stem cells. They reported in the August 2, 2017, online edition of the journal Nature that all resulting growths that deformed the skin tissue architecture regressed, irrespective of their size. Wild-type cells were required for the active elimination of mutant cells from the tissue, while utilizing both endogenous and ectopic cellular behaviors to dismantle the aberrant structures.

After regression, the remaining structures were either completely eliminated or converted into functional skin appendages in a niche-dependent manner. Furthermore, tissue aberrancies generated from oncogenic cells, and even mutation-independent deformations to the tissue could also be corrected, indicating that this tolerance phenomenon reflected a conserved principle in the skin.

"The normal cells can even corral and escort mutant cells out of the tissue and clean up the mess the mutant cells left behind, in order to keep the tissue healthy and functional," said first author Samara Brown, a graduate researcher at Yale University.

Related Links:
Yale University


Print article

Channels

Biochemistry

view channel
Image: A space-filling model of the anticonvulsant drug carbamazepine (Photo courtesy of Wikimedia Commons).

Wastewater May Contaminate Crops with Potentially Dangerous Pharmaceuticals

Reclaimed wastewater used to irrigate crops is contaminated with pharmaceutical residues that can be detected in the urine of those who consumed such produce. Investigators at the Hebrew University... Read more

Business

view channel

Collaborative Agreement to Aid in Setting Guidelines for Evaluating Potential Ebola Therapy

Cooperation between an Israeli biopharmaceutical company and medical branches of the US government is designed to set ground rules for continued evaluation of an experimental therapy for Ebola virus disease. RedHill Biopharma Ltd. (Tel Aviv, Israel), a biopharmaceutical company primarily focused on development and c... Read more
Copyright © 2000-2017 Globetech Media. All rights reserved.