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Drug Discovery

Image: A photomicrograph of a cross section of a mouse aorta, the main artery in the body, with a large plaque. Straight red lines toward the upper left are the wall of the aorta. Yellow areas are where housekeeping cells called macrophages are clearing cellular waste (Photo courtesy of Ismail Sergin, Washington University School of Medicine).

Trehalose Boosts Macrophage Ability to Clear Plaques

Cardiovascular disease researchers working with mouse models have found that treatment with the sugar trehalose boosts the activity of the macrophages responsible for clearing the molecular and cellular debris that make up atherosclerotic plaques. More...
22 Jun 2017
Image: A model of the KRAS protein with important domains highlighted (Photo courtesy of ResearchGate).

Exosomes Prove Superior for Transporting Anticancer MicroRNAs

Cancer researchers used modified exosomes to transport inhibitory siRNA molecules to block the activity of the KRAS oncogene and thereby suppress cancer development in multiple mouse models of pancreatic cancer and significantly increase overall survival. More...
20 Jun 2017
Image: A photomicrograph showing T-cells (red) and tumor cells (green) incubated with control particles (left) or immunoswitch particles (right). The T-cells that have attached to tumor cells are indicated by green arrows (Photo courtesy of Alyssa Kosmides, Johns Hopkins University).

Bifunctional Nanoparticles Show Potential in Cancer Models

To be successful, an immunotherapeutic approach for treating cancer must overcome the immunosuppressive effects of the tumor microenvironment; a novel bifunctional nanoparticle does just that. More...
19 Jun 2017
Image: Dr. Kim and his team are using breakthrough gene-editing technology to develop a new screening tool for Parkinson’s disease. The technology allows scientists in the lab to “light up” and then monitor a brain protein called alpha-synuclein that has been associated with Parkinson’s (Photo courtesy of the University of Central Florida).

CRISPR/Cas9 Technology Used to Help Screen for PD

A team of neurodegenerative disease researchers used CRISPR/Cas9 gene editing technology to introduce a luminescent reporter into the gene that encodes the pathogenic protein alpha-synuclein, an approach that they plan to develop into a screening tool for drugs to treat Parkinson's disease (PD). More...
16 Jun 2017
Image: A glucose-controlling drug (blue) is shown completely dissolving after 24 hours in the body of a mouse in the top two photos. In the bottom two images, a newly optimized version of a diabetes treatment forms a \"depot\" for controlled release that persists more than 24 hours (Photo courtesy of Dr. Ashutosh Chilkoti, Duke University).

Time-Release Approach for Treating Type II Diabetes

A novel approach to treating type II diabetes is based on a timed-release suspension of glucagon-like peptide-1 (GLP1) embedded in a thermosensitive elastin-like polypeptide complex. More...
13 Jun 2017
Image: In cancer, cells divide uncontrollably and invade surrounding tissues. By removing a specific protein from cells, researchers were able to slow the cell cycle (Photo courtesy of the University of Rochester Medical Center).

Protein Slows Cancer with Cell Cycle Interference

A team of molecular biologists has identified a pathway that mediates mature microRNA (miRNA) decay - a process of undoing gene silencing that is less well understood than the processes that mediate miRNA biosynthesis. More...
05 Jun 2017
Image: When free C3d vaccine was added to a tumor, the cancer cells began to die (right). Tumor cells not given the vaccine continued to grow (Photo courtesy of the University of Michigan).

Protein Fragment Promotes Anti-Cancer Response

Free C3d protein, a fragment of the third component of complement, has been found to prevent cancer cells from avoiding the body's immune response and has potential to be developed into a chemotherapeutic agent for cancer treatment. More...
22 May 2017
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The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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