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Drug Discovery

Image: A micrograph of the West Nile virus (shown in yellow) (Photo courtesy of Wikimedia Commons).

Vaccine Cures and Protects against West Nile Virus

Treatment with a novel siRNA-based vaccine offered efficient late-stage therapy and facilitated development of natural long-term immunity against West Nile virus in a mouse model system. More...
18 Apr 2018
Image: New possible health benefits have been linked to the anthocyanidin family of berry pigments, which includes wild bilberries (Photo courtesy of Shutterstock).

Finnish Study Describes Activators of SIRT6 Gene

A team of Finnish researchers conducted a study to evaluate the differences in chemical features between inhibitors and activators of the cancer-related SIRT6 gene. More...
17 Apr 2018
Image: Under a very-high magnification, this digitally colorized scanning electron micrograph (SEM) depicts a number of filamentous Ebola virus particles (red) that had budded from the surface of a VERO cell (brown) of the African green monkey kidney epithelial cell line (Photo courtesy of the [U.S.] National Institute of Allergy and Infectious Diseases).

Compound Demonstrates Potential as Broad-Spectrum Antiviral Drug

A team of molecular biologists identified a potent drug candidate with specificity towards especially deadly viruses such as Ebola virus and Marburg virus. More...
12 Apr 2018
Image: A diagram of a 5-AZA resistant chromatin structure (Photo courtesy of Dr. Jason Cheng).

Role of RNA Methylation Defined in Drug Resistance by Leukemia Cells

Results of a recent study defined the roles of RNA 5-methylcytosine (RNA:m5C) and RNA:m5C methyltransferases (RCMTs) in the formation of discrete chromatin structures that modulate 5-Azacitidine (5-AZA) response or resistance in leukemia cells. More...
05 Apr 2018
Image: A family of economical silver-based complexes shows very promising results against a number of human cancers in laboratory tests, with very low toxicity in rat studies and minimal effects on healthy cells. One of these complexes, UJ3, is as effective as the industry-standard drug Cisplatin in killing cancer cells in laboratory tests done on human esophageal cancer, breast cancer, and melanoma. This matrix of light microscope images shows a comparison of human esophageal cancer cells treated with UJ3 and Cisplatin (Photo courtesy of Dr. Zelinda Engelbrecht, University of Johannesburg).

Less Toxic Drugs May Replace Current Chemotherapeutic Agents

A team of South African cancer researchers has suggested replacing the current frontline platinum-based chemotherapeutic drugs with first generation silver(I) phosphines, which have vast structural diversity and promising anticancer activity. More...
04 Apr 2018
Image: Ripe pecan-nuts photographed on a tree in Hadera, Israel (Photo courtesy of Wikimedia Commons).

Pecan-Enriched Diet Protects against CV Disease and Diabetes

Results of a randomized, controlled feeding trial suggested that eating just 1.5 ounces (44.36 milliliters) of pecans every day could protect adults at risk for developing cardiovascular disease (CVD) and type II diabetes. More...
03 Apr 2018
Image: The binding site of the amino acid transporter inhibitor UCPH101 was resolved by X-ray crystallography and was located at a distance from the substrate-binding site. In the image, the substrate is shown in the center of the transporter, while the inhibitor is located between the translocation and scaffold domain of the transporter (lower right). The inhibitor glues the two domains together, thereby inhibiting transport (Photo courtesy of Dr. Stefan Broer).

Review Article Summarizes Progress Towards Drug Development

A recent review article summarized the methods used to identify new inhibitors for amino acid transporters and outlined cell and organ function where these can be used to modulate, prevent, or to treat diseases. More...
02 Apr 2018

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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