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Drug Discovery

Image: The water flea Daphnia pulex, source of the MfR protein subunits Met and SRC (Photo courtesy of Wikimedia Commons).

Alternative Technique Developed for Toxicity Screening

An innovative high-throughput screening technique is expected to improve drug development strategies by greatly reducing the time required to identify the potential for expression of toxic side effects. More...
20 Sep 2017
Image: A scanning electron micrograph (SEM) of an ovarian cancer cell (Photo courtesy of Steve Gschmeissner / SPL).

Lack of Correlation in Cancer Cells May Complicate Drug Development

Cancer researchers have are warning drug developers that in about 62% of ovarian cancer cell samples levels of messenger RNA and protein did not accurately reflect changes in gene activity. More...
07 Sep 2017
Image: A new approach to treating arthritis is based on the polysaccharide alginate isolated from the brown algae Laminaria hyperborean (Photo courtesy of Wikimedia Commons).

Scandinavian Researchers Discover Potential Arthritis Treatment

The natural polysaccharide alginate and particularly its sulfated derivatives have potent anti-oxidant, anti-inflammatory, and anti-immunogenic properties, which indicate that it may be a promising biomaterial to be explored for treatment of arthritis. More...
06 Sep 2017
Image: Digitally colorized scanning electron microscopic image showing Salmonella Typhi bacteria (red) invading an immune cell (yellow) (Photo courtesy of the CDC Public Health Image Library).

Genetic Variant Links Typhoid Susceptibility to Cholesterol Level

A team of molecular microbiologists has linked genetically controlled levels of cellular cholesterol to susceptibility of invasion by Salmonella enterica serovar Typhi (S. Typhi), the bacterium that causes typhoid fever. More...
05 Sep 2017
Image: A molecular model of Takinib, a drug-like molecule that modulates the TNF-alpha inflammatory response, which is at the center of a variety of diseases (Photo courtesy of Duke University).

X-ray Study Explains How Takinib Inhibits TNF-alpha

Takinib, a selective TAK1 inhibiting drug, has been shown to broaden the therapeutic efficacy of TNF-alpha (Tumor necrosis factor-alpha) inhibition for treating cancer and autoimmune diseases. More...
29 Aug 2017
Image: The method uses vibrational microspectroscopic technology, including Fourier Transform Infrared (FT-IR) and Raman laser microspectroscopy, to detect the unique molecular vibrations of different compounds. These vibrations contain information about the sample’s chemical composition, including molecular characteristics, prevalence, and structure (Photo courtesy of Umeå University).

Spectroscopy Reveals Fingerprints for Diabetes Progression

Researchers report a method to study biochemical changes that occur in the pancreas during the development of diabetes. Based on vibrational microspectroscopic technology, the method can be used to extract biochemical profiles containing information about disease progression. This could facilitate improved understanding of key mechanistic processes in diabetes development and manifestation, and could be used to develop better prognostic, diagnostic, and monitoring tools. More...
28 Aug 2017
Image: Folate as a yellow-orange crystalline powder (Photo courtesy of Wikimedia Commons).

Folate-Bound MicroRNAs Slow Tumor Progression in Models

A growth-inhibiting microRNA conjugated to molecules of folate reduced tumor size when delivered to mice with lung and breast cancer tumors that overexpressed the folate receptor. More...
15 Aug 2017
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The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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