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Drug Discovery

Image: A digitally colorized transmission electron micrograph (TEM) of Zika (Photo courtesy of the CDC).

DNA-Based Vaccine Shown Safe and Effective

A team of vaccine developers used an advanced electroporation method to deliver and evaluate a new generation DNA-based vaccine designed to protect against Zika virus (ZIKV) infection. More...
16 Oct 2017
Image: A model of a potent peptide that targets influenza virus hemagglutinin and mimics the functionality of a broadly neutralizing antibody (Photo courtesy of Rameshwar U. Kadam, Ian Wilson\'s Laboratory, The Scripps Research Institute).

Potential Peptide Drugs Block Influenza Virus Activity

A recent paper described the design and structural characterization of a class of potent peptide inhibitors specifically targeted to block the activity of influenza virus hemagglutinin. More...
12 Oct 2017
Image: Ambrosia arborescens, the source of compounds toxic to cancer stem cells, is a medicinal plant with analgesic, anti-inflammatory, and antiseptic properties (Photo courtesy of Wikimedia Commons).

Anticancer Compounds Found in Medicinal Plant

Compounds isolated from the medicinal plant Ambrosia arborescens or derived from them synthetically were found to have potent toxic effect on cancer stem cells in three different breast cancer cell lines. More...
11 Oct 2017
Image: The Crystallographic structure of NR0B1 (rainbow colored) complexed with the nuclear receptor protein LRH-1 (Liver receptor homolog-1) (Photo courtesy of Wikimedia Commons).

Advanced Proteomics Strategy Identifies Promising Drug Target

Use of an advanced proteomics strategy led to the discovery of a protein in non-small-cell lung cancer (NSCLC) cells that could be targeted by low molecular weight drugs. More...
09 Oct 2017
Image: After the lids are deposited onto the cups, the particles are heated slightly to form a tight seal between the lids and cups (Photo courtesy of the Langer Lab).

Drug Delivery Method Used with Hollow Microstructures

A new method for producing microstructures was used to create hollow injectable microparticles that could be filled with liquid containing a therapeutic agent and then degraded over a programmable time period. More...
27 Sep 2017
Image: The human leukocyte antigen (HLA) ligand for a Killer-cell immunoglobulin-like receptor (KIR) (Photo courtesy of Wikimedia Commons).

Novel Vaccine Could Simultaneously Target Multiple Viral Infections

A novel vaccine designed to prevent infection by several different viruses simultaneously in based on ability of a receptor protein on the surface of immune cells to recognize a common, invariable viral antigen. More...
26 Sep 2017
Image: A transmission electron micrograph (TEM) of a number of Lassa virus virions adjacent to some cell debris. The virus, a member of the virus family Arenaviridae, causes Lassa fever (Photo courtesy of the CDC).

Monoclonal Antibody-based Vaccine Prevents Lassa Fever in Model

A combination of human monoclonal antibodies was used to protect monkeys infected with Lassa fever virus and prevented infection even when administered as late as eight days after exposure to the virus. More...
22 Sep 2017
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The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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