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Drug Discovery

Image: Six days after treatment with IGF-1 carried by dendrimer nanoparticles (blue), the particles have penetrated through the cartilage of the knee joint (Photo courtesy of Brett Geiger and Jeff Wyckoff, Massachusetts Institute of Technology).

Deeply Penetrating Nanoparticles Designed to Treat Osteoarthritis

A novel nanoparticle-based drug transport system designed to treat osteoarthritis delivers the anabolic growth factor IGF-1 (insulin-like growth factor 1) directly to injured chondrocytes, which are located deep within a dense layer of cartilage tissue. More...
12 Dec 2018
Image: Graph shows elevated activity of a transcription-factor network that includes the molecule onecut2 in tumors of patients whose prostate cancer resisted hormone therapy (above purple bar) compared with other types (Photo courtesy of the Nature Publishing Group).

Hormone Treatment Linked to Development of Aggressive Cancer

A team of cancer researchers has identified a gene that promotes the growth and spread of the most aggressive type of prostate cancer. More...
06 Dec 2018
Image: Skeletal formula of mannose-6-phosphate, a form of mannose that impairs   glucose metabolism (Photo courtesy of Wikimedia Commons).

Mannose Treatment Enhances Chemotherapy and Slows Growth of Cancers

Cancer researchers have found that treatment with mannose leads to growth retardation in several tumor types in vitro and in a mouse model system and enhances cell death in response to major forms of chemotherapy. More...
05 Dec 2018
Image: Two components of Mallotus leaf extract bind to a previously unrecognized binding site on KCNQ1, a potassium channel essential for controlling electrical activity in many human organs. The image shows a computer model illustrating the novel herbal component, CPT1, an isovaleric acid molecule (green), occupying a novel binding site (R243, red) to activate KCNQ1 (Photo courtesy of Dr. Geoffrey Abbott, University of California, Irvine School of Medicine).

African Folk Drug Modulates Critical Potassium Channel Protein

A leaf extract used for hundreds of years in African folk medicine was shown to act by influencing the behavior of a protein that forms a critical potassium channel found in many human organs. More...
29 Nov 2018
Image: Researchers developed a technique to prepare polyol-modified nanoparticles that could locate cancerous cells and tumors via the blood vessels surrounding the tumors (Photo courtesy of Purdue University).

Modified Nanoparticle Drug Carriers Target Solid Tumors in Model

Cancer researchers used novel targeted nanoparticles to transport drugs to solid tumors when the absence of a persistent EPR (enhanced permeability and retention) effect, acted as an access barrier negatively affected the effectiveness of drug delivery. More...
27 Nov 2018
Image: A transmission electron microscopic (TEM) image of influenza A virions in late passage growth phase (Photo courtesy of the CDC).

Linked Antibodies Provide Universal Protection from Influenza Infection

A potential universal vaccine that would protect individuals from infection by all strains of influenza virus is based on multidomain antibodies that were fabricated by combining selected llama single-domain antibodies. More...
22 Nov 2018
Image: Silicon nanoneedles embedded in a stretchable and translucent elastomer patch that can be worn on the skin to deliver exact doses of drugs directly into cells (Photo courtesy of Purdue University).

Nanoneedle Bio-patch Provides Minimally Invasive Drug Delivery

A flexible bio-patch made from silicon nanoneedles embedded in a thin layer of elastomer was shown to deliver exact doses of biomolecules to cells and tissues while minimizing discomfort to the wearer. More...
20 Nov 2018

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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