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02 Sep 2018 - 05 Sep 2018

Drug Discovery

Image: The figure shows two views, frontal and lateral, of the image obtained by CT of the lungs of a mouse with fibrosis (grey areas) before and after receiving nano-therapy directed at senescent cells (Photo courtesy of Guillem Garaulet and Francisca Mulero, Institute for Research in Biomedicine).

Gel Encapsulation Transport System Targets Disease-Related Cells

A novel therapeutic approach uses drugs encapsulated within galacto‚Äźoligosaccharide gel capsules to target diseases that have accumulated a high percentage of senescent cells. More...
10 Aug 2018
Image: Image shows the effect particles coated with phage (red) have on bacterial colonies (green). The dark green areas around the particles show areas where bacteria are being killed. (Photo courtesy of Rachit Agarwal, Garcia Laboratory, Georgia Institute of Technology).

Bacteriophages Delivered by Dry Powder Cure Lung Diseases in Model

A novel antibacterial transport system utilized a dry powder approach to deliver microparticles coated with bacteriophages to difficult to access areas in the lungs. More...
03 Aug 2018
Image: Combining a nanocarrier with antibodies under acidic conditions results in the antibodies attaching to the drug carrier in a stable way. This makes it possible for nanocarriers to target diseased tissue (Photo courtesy of Stefan Schuhmacher).

Adsorption Procedure Enhances Efficiency of Drug Transport

A simple adsorption procedure enhances the efficiency of nanocarrier transport of toxic drugs to tumors. More...
31 Jul 2018
Image: A ball-and-stick model of the docosahexaenoic acid (DHA) molecule. DHA is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, and retina (Photo courtesy of Wikimedia Commons).

Synthetic Fatty Acid Derivatives Display Anti-Cancer Potential

Metabolites produced during digestion of omega-3 fatty acids have been found to have anti-cancer properties, and their synthetic derivatives have the potential to be developed into potent chemotherapeutic drugs. More...
26 Jul 2018
Image: A hairpin loop from a pre-mRNA. Highlighted are the nucleobases (green) and the ribose-phosphate backbone (blue). This is a single strand of RNA that folds back upon itself (Photo courtesy of Wikimedia Commons).

Identifying Potential Drugs that Modify RNA Expression

A team of drug developers has described a small molecule microarray-based approach that allows for unmodified low molecular weight compounds, including [U.S.] Food and Drug Administration-approved drugs, to be probed for binding to RNA motif libraries in a massively parallel format. More...
12 Jul 2018
Image: Three-dimensional super-resolution microscopy shows that breast cancer cells (left) contain many large multivesicular bodies (green and red) that are full of exosomes ready to be released from the cell. In the absence of Munc13-4 (right), multivesicular bodies are much smaller and incapable of releasing their contents (Photo courtesy of Messenger et al., 2018).

Enzyme Elimination Blocks Exosome Release and Slows Cancer

Cancer researchers identified a molecular mechanism that enables aggressive cancer cells to manufacture and secrete large numbers of exosomes, which are critical for cancer progression and spreading. More...
04 Jul 2018
Image: Atherosclerotic lesions appear in red in this photomicrograph of a mouse aorta (Photo courtesy of Cedars-Sinai Medical Center).

Excess Inflammasome Activity Leads to Formation of Atherosclerosis

Results presented in a recently published paper explain how chronic inflammation of the arterial walls progresses to arteriosclerosis, a disorder characterized by clogged arteries and increased risk of heart attack and stroke. More...
03 Jul 2018

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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