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11 Jun 2017 - 15 Jun 2017
19 Jun 2017 - 22 Jun 2017

Drug Discovery

Image: When free C3d vaccine was added to a tumor, the cancer cells began to die (right). Tumor cells not given the vaccine continued to grow (Photo courtesy of the University of Michigan).

Protein Fragment Promotes Anti-Cancer Response

Free C3d protein, a fragment of the third component of complement, has been found to prevent cancer cells from avoiding the body's immune response and has potential to be developed into a chemotherapeutic agent for cancer treatment. More...
22 May 2017
Image: Fluorescent imaging of a tumor section identifies different types of macrophages (green) and T-cells (blue) present in the microenvironment of renal cell carcinoma (Photo courtesy of Karina Silina, University of Zurich).

Mass Cytometry Profiles to Aid Drug Development

Cancer researchers used a novel mass cytometry technique to reveal potential biomarkers for detection of renal cell carcinoma and to identify targets for development of immunotherapeutic agents to treat this essentially incurable disease. More...
15 May 2017
Image: A Magnolia grandiflora seed cone, a primary source of honokiol (Photo courtesy of Wikimedia Commons).

Honokiol Stimulation Used to Prevent Hypertrophy

The ancient herbal therapy substance honokiol, which is derived from the bark, seed cones, and leaves of trees belonging to the genus Magnolia, has chemical properties that enable it to protect the heart from hypertrophy. More...
08 May 2017
Image: A sample of silicon dioxide (Photo courtesy of Wikimedia Commons).

Silicon Treatment Preserves Antibiotics and Vaccines for Years

A novel method for encasing molecules of biomedical interest such as antibodies and vaccines in silica "cages" stabilizes them against denaturing thermal treatment and long-term ambient-temperature storage, and subsequently enables them to be released into solution with their structure and function intact. More...
03 May 2017
Image: New research reveals that the potential of Penicillia fungi for production of novel antibiotics is far from exhausted. The isolation of novel bioactive compounds from these species represents a source of new antibiotics to fight infectious microorganisms (Photo courtesy of Jens Christian Nielsen, Chalmers University of Technology).

Researchers Reevaluate Fungi to Produce New Drugs

Despite being the source of the first clinically administered antibiotic (penicillin), which was isolated by Alexander Fleming in 1928, the Penicillium species of fungi (Penicillia) continues to fascinate drug developers. More...
02 May 2017
Image: Circulating white blood cells, commonly referred to as leukocytes (large yellow clusters), can be seen lining an inflamed vessel wall along with leukosomes (small yellow speckles). Leukosomes, designed to mimic white blood cells, go unnoticed as they accumulate at the inflamed vessel (purple background), allowing them to concentrate their therapeutic payload at the target site (Photo courtesy of Houston Methodist Hospital).

Study Explains How Drug Carriers Interact with Immune System

Researchers seeking to develop nanoparticle-based drug delivery systems have determined how a specialized class of nanoparticles called leukosomes avoids immune system response in a mouse model system. More...
20 Apr 2017
Image: Crystal structures of Mtb RNAP bound to rifampin (left) and Mtb RNAP bound to an AAP (right) show the Mtb RNAP interactions. Gray ribbons, Mtb RNAP backbone; gray, cyan, and green sticks, Mtb RNAP, rifampin, and AAP carbon atoms; red and blue sticks, oxygen and nitrogen atoms; green mesh, mFo-Fc electron density omit map; BH, Mtb RNAP bridge helix (Photo courtesy of Wei Lin and Richard H. Ebright, Rutgers University).

X-Ray Crystallography Findings Aid Discovery of New Drugs

Sensitive X-ray crystallography techniques were used to determine the three-dimensional (3D) molecular structure of the Mycobacterium tuberculosis enzyme RNA polymerase (Mtb RNAP) alone and when bound to the present first-line anti-tuberculosis drug rifampin. More...
18 Apr 2017

Product Showcase

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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