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Therapeutics

Image: Researchers have produced insulin-secreting cells from stem cells derived from the skin of patients with type I diabetes. The cells (blue), made from stem cells, can secrete insulin (green) in response to glucose (Photo courtesy of Millman Laboratory, Washington University School of Medicine).

Researchers Generate Stem Cell-derived Beta-cells from Patients with Diabetes

Diabetes researchers have succeeded in generating functional insulin-secreting beta cells from stem cells derived from patients with the type I form of the disease. More...
01 Jun 2016
Image: A fluorescent micrograph of glioblastoma cells (Photo courtesy of the International School of Advanced Studies).

Novel Gene Therapy Approach Kills Glioblastoma Tumors In Vitro and In Vivo

Gene therapy to increase expression of the enzyme Emx2 (Homeobox protein Emx2) in glioblastoma multiforme (GBM) tumor cells was shown to destroy the cancer in vitro and prevent its recurrence in vivo. More...
31 May 2016
Image: A fluorescent micrograph of glioblastoma cells (Photo courtesy of the International School of Advanced Studies).

Novel Gene Therapy Approach Kills Glioblastoma Tumors in Vitro and in VivoNovel Gene Therapy Approach Kills Glioblastoma Tumors in Vitro and in Vivo

Gene therapy to increase expression of the enzyme Emx2 (Homeobox protein Emx2) in glioblastoma multiforme (GBM) tumor cells was shown to destroy the cancer in vitro and prevent its recurrence in vivo. More...
27 May 2016
Image A: A scanning electron micrograph (SEM) of an E. coli bacterium of the pandemic H30 strain (Photo courtesy of the University of Washington).

Study Improves Understanding of E. coli H30 Epidemiology, Persistent Infections Remains Unexplained

Researchers have identified populations more vulnerable to infection with pandemic E. coli strain H30, however improved testing is needed to monitor patients due to the high rate of treatment failure. Antibiotic resistance and weakened immunity only partially explain persistent infection. More...
05 May 2016

New Approach Improves Identification of Women at High Risk of Preeclampsia

A new meta-analysis examining 92 cohort studies involving over 25 million pregnancies has provided an unprecedented understanding of risk factors for preeclampsia—some risk factors being strong enough to warrant that a pregnant woman starts on prophylactic treatment with acetylsalicylic acid (ASA) when she has only one. More...
05 May 2016
Image: A confocal microscopy image of human fibroblasts derived from embryonic stem cells. The nuclei appear in blue, while smaller and more numerous mitochondria appear in red (Photo courtesy of Dr. Shoukhrat Mitalipov, Oregon Health & Science University).

Stem Cells Derived from Older Individuals May Carry Unsafe Mitochondrial DNA Mutations

Induced pluripotent stem cells (iPSCs) derived from the skin fibroblasts of older individuals have a likelihood of harboring mitochondrial DNA mutations, which may render them unfit for clinical applications. More...
29 Apr 2016
Image: A small library of abietane-type diterpenoids amides was prepared from the plant-based dehydroabietylamine (left (1)) as a starting material, and the compounds evaluated for activity against Leishmania donovani and Trypanosoma cruzi. One compound (right (10)), an amide built from dehydroabietylamine and acrylic acid, was found to be highly effective against both parasites (Photo courtesy of Pirttimaa M et al., 2016, Journal of Natural Products).

Newly Developed Drug Demonstrates Potent, Selective Activity Against Trypanosomatid Parasites

Using a plant-based compound, scientists have developed a semi-synthetic drug that, upon testing on infected mammalian cells in culture, showed highly effective activity against two parasites from the trypanosomatid family: Leishmania donovani, a cause of visceral leishmaniasis, and Trypanosoma cruzi, cause of Chagas disease.  More...
06 Apr 2016
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BioResearch Therapeutics channel deals with all aspects of therapies beyond the five-year horizon.
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