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11 Jun 2017 - 15 Jun 2017
19 Jun 2017 - 22 Jun 2017

Drug Discovery

Image: The molecular model of the protein IkappaBalpha (NF-kappaB inhibitor, alpha) (Photo courtesy of Wikimedia Commons).

Interrupting a Molecular Signaling Pathway to Treat Prostate Cancer

Cancer researchers have traced a molecular pathway that is active in treatment resistant prostate cancer and have suggested therapeutic strategies to circumvent it. More...
11 Jan 2017
Image: A ball and stick model of artemisinin (Photo courtesy of Wikimedia Commons).

Artemisinin Hastens TB Cure by Preventing Bacteria from Becoming Dormant

A team of microbiologists has found that a drug usually used to treat malaria can shorten the time needed to treat tuberculosis (TB) by preventing the causative organism (Mycobacterium tuberculosis) from entering a dormant, drug resistant state. More...
05 Jan 2017
Image: A homology model of the TRPV1 calcium ion channel (Photo courtesy of Wikimedia Commons).

Activation of Channel Proteins Slows Cancer Cell Growth and Impairs Metastatic Capability

A team of German researchers working with an aggressive breast cancer cell line showed that activation of TRPV1, a transient receptor potential channels protein, caused significant inhibition of cancer cell growth and induced apoptosis and necrosis. More...
04 Jan 2017
Image: A colored scanning electron micrograph (SEM) of actinomycete bacteria (Photo courtesy of Getty Images).

Soil Bacteria As a Rich Source of Enediyne Antibiotics and Anti-Cancer Compounds

Following the screening of more than 3,400 different actinomycete (soil bacteria) isolates, researchers have isolated several powerful new antibiotics and potential anti-cancer compounds. More...
04 Jan 2017
Image: The molecular model of the ARID1A protein (Photo courtesy of Wikimedia Commons).

ARID1A Mutations Linked to ATR Anti-Cancer Drug Sensitivity

A team of British cancer researchers suggested in a recent paper that screening for mutations in the ARID1A (AT-rich interactive domain-containing protein 1A) gene could aid in identifying patients with tumors sensitive to the ATR inhibitor class of anti-cancer drugs. More...
03 Jan 2017
Image: Pneumocystis jirovecii is present in this lung impression smear, using Giemsa stain. This fungus is arguably the most important cause of pneumonia in the immunocompromised human host (Photo courtesy of the CDC).

New Drug Treatments to Target Pneumocystis Dependence on Inositol Transport

A recent paper suggested that the Pneumocystis fungus, a dangerous pathogen that causes pneumonia in HIV patients and other immunocompromised individuals, could be targeted by drugs that would block its inositol transport mechanism. More...
29 Dec 2016
Image: An illustration of the high-risk (left) and low-risk (right) versions of the ZnT8 protein as it transports zinc ions (purple spheres) across a cell membrane, where it binds with insulin (green and yellow). The letters show the difference in the DNA code that produces the variation in proteins (Photo courtesy of Drs. Chengfeng Merriman and Dax Fu, Johns Hopkins University).

Preventing Type II Diabetes Requires Putting the Brakes on Zinc Transport Protein

The enhanced activity of a zinc transport protein encoded by a fairly common gene variant has been linked to heightened risk of developing type II diabetes. More...
29 Dec 2016

Product Showcase

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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