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Drug Discovery

Image: A scanning electron micrograph (SEM) image of human red blood cells (Photo courtesy of MPI).

Light-Activated Drug Transport System Based on RBC Carriers

A novel system for precise delivery of toxic anticancer drugs is based on the use of red blood cells as carriers to transport immobilized drug complexes that are released at specific sites upon exposure to light. More...
18 Jan 2017
Image: An artist’s conception of nanoparticle-carrying immune cells that target tumors and release drug-loaded nanoparticles for cancer treatment (Photo courtesy of Jian Yang and Yixue Su, Pennsylvania State University).

Researchers Demonstrate Potential of Drug Delivery System for Melanoma

A novel delivery system for anticancer drugs is based on biodegradable theranostic nanoparticles transported by immune cells that are naturally attracted to the site of the growing tumor. More...
12 Jan 2017
Image: A ball-and-stick model of the metformin molecule (Photo courtesy of Wikimedia Commons).

Drug Combination Selectively Prevents Cancer Cell Growth

The antihypertension drug syrosingopine has been found to drastically reduce the concentration of the diabetes medication metformin required to destroy cancer cells in culture and in a mouse liver cancer model. More...
12 Jan 2017
Image: The molecular model of the protein IkappaBalpha (NF-kappaB inhibitor, alpha) (Photo courtesy of Wikimedia Commons).

Interrupting a Molecular Signaling Pathway to Treat Prostate Cancer

Cancer researchers have traced a molecular pathway that is active in treatment resistant prostate cancer and have suggested therapeutic strategies to circumvent it. More...
11 Jan 2017
Image: A ball and stick model of artemisinin (Photo courtesy of Wikimedia Commons).

Artemisinin Hastens TB Cure by Preventing Bacteria from Becoming Dormant

A team of microbiologists has found that a drug usually used to treat malaria can shorten the time needed to treat tuberculosis (TB) by preventing the causative organism (Mycobacterium tuberculosis) from entering a dormant, drug resistant state. More...
05 Jan 2017
Image: A homology model of the TRPV1 calcium ion channel (Photo courtesy of Wikimedia Commons).

Activation of Channel Proteins Slows Cancer Cell Growth and Impairs Metastatic Capability

A team of German researchers working with an aggressive breast cancer cell line showed that activation of TRPV1, a transient receptor potential channels protein, caused significant inhibition of cancer cell growth and induced apoptosis and necrosis. More...
04 Jan 2017
Image: A colored scanning electron micrograph (SEM) of actinomycete bacteria (Photo courtesy of Getty Images).

Soil Bacteria As a Rich Source of Enediyne Antibiotics and Anti-Cancer Compounds

Following the screening of more than 3,400 different actinomycete (soil bacteria) isolates, researchers have isolated several powerful new antibiotics and potential anti-cancer compounds. More...
04 Jan 2017

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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