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11 Jun 2017 - 15 Jun 2017
19 Jun 2017 - 22 Jun 2017


Image: A homology model of the TRPV1 calcium ion channel (Photo courtesy of Wikimedia Commons).

Activation of Channel Proteins Slows Cancer Cell Growth and Impairs Metastatic Capability

A team of German researchers working with an aggressive breast cancer cell line showed that activation of TRPV1, a transient receptor potential channels protein, caused significant inhibition of cancer cell growth and induced apoptosis and necrosis. More...
04 Jan 2017
Image: High molecular weight tau bands (about 80kDa) can be visualized, with greater immunoreactivity, in patients with AD compared with healthy subjects (Photo courtesy of Dr. Ricardo B. Maccioni, University of Chile).

Assessment of Tau Protein Status for Early Detection of Alzheimer's Disease

The ratio of normal to aggregated tau protein found in blood platelets has been suggested as a biomarker that could be used for the early detection of Alzheimer's disease. More...
03 Jan 2017
Image: The molecular model of the ARID1A protein (Photo courtesy of Wikimedia Commons).

ARID1A Mutations Linked to ATR Anti-Cancer Drug Sensitivity

A team of British cancer researchers suggested in a recent paper that screening for mutations in the ARID1A (AT-rich interactive domain-containing protein 1A) gene could aid in identifying patients with tumors sensitive to the ATR inhibitor class of anti-cancer drugs. More...
03 Jan 2017
Image: The molecular structure model of HDAC6 (Histone deacetylase 6) protein (Photo courtesy of Wikimedia Commons).

Phosphatidylserine Reverses Neurodegeneration in Mouse Model of Familial Dysautonomia

A genetically engineered mouse model system was used to study the role of the IKAP protein in the neurodegeneration process that underlies the genetic disease Familial dysautonomia and to show that treatment with phosphatidylserine could alleviate symptoms of the disease. More...
03 Jan 2017
Image: A proposed model of hnRNPA2 (in gray) shows where acetyl-CoA (green) can \"dock\" and interact with different components of the protein. These interactions allow it to transfer acetyl-CoA groups to nuclear gene promoters and translate mitochondrial stress to nuclear gene activation, a process associated with cancer progression (Photo courtesy of the University of Pennsylvania).

Protein Identified Modifies Gene Expression in Response to Mitochondrial Damage

A protein has been identified that causes changes in cellular gene expression in response to stress or disease related impairment in mitochondrial function. More...
03 Jan 2017
Image: Pneumocystis jirovecii is present in this lung impression smear, using Giemsa stain. This fungus is arguably the most important cause of pneumonia in the immunocompromised human host (Photo courtesy of the CDC).

New Drug Treatments to Target Pneumocystis Dependence on Inositol Transport

A recent paper suggested that the Pneumocystis fungus, a dangerous pathogen that causes pneumonia in HIV patients and other immunocompromised individuals, could be targeted by drugs that would block its inositol transport mechanism. More...
29 Dec 2016
Image: An illustration of the high-risk (left) and low-risk (right) versions of the ZnT8 protein as it transports zinc ions (purple spheres) across a cell membrane, where it binds with insulin (green and yellow). The letters show the difference in the DNA code that produces the variation in proteins (Photo courtesy of Drs. Chengfeng Merriman and Dax Fu, Johns Hopkins University).

Preventing Type II Diabetes Requires Putting the Brakes on Zinc Transport Protein

The enhanced activity of a zinc transport protein encoded by a fairly common gene variant has been linked to heightened risk of developing type II diabetes. More...
29 Dec 2016

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BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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