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Genomics/Proteomics

Image: The crystal structure of STAT3 bound to DNA (Photo courtesy of Wikimedia Commons).

STAT3 Linked to Interferon-Induced Antiviral Response

A recent paper reported the discovery of a previously unknown anti-viral role for the STAT3 (signal transducer and activator of transcription 3) protein, which links it to the interferon-alpha (IFN-alpha) immune signaling pathway. More...
09 Feb 2017
Image: Atorvastatin bound to HMG-CoA reductase (Photo courtesy of Wikimedia Commons).

Statins Slow Growth of Cancers with p53 Structural Mutations

Cancer researchers have demonstrated the ability of cancer-lowering statin drugs to slow the growth of certain types of cancers with p53 mutations. More...
08 Feb 2017
Image: Researchers have synthesized an antisense oligonucleotide (ASO) that can lower tau levels and prevent some neurological damage. In neurons that contain the ASO (above, in red) there are no tau tangles (in green) (Photo courtesy of Dr. Sarah DeVos, Washington University School of Medicine).

Antisense Therapy Lowers Levels of Pathogenic Tau Protein in Models

Antisense therapy was used to reverse the damage caused by accumulation of tau protein in mouse and monkey models of neurodegenerative diseases. More...
08 Feb 2017
Image: A colorized scanning electron micrograph (SEM) depicting mitochondria, which play a critical role in peripheral nerve growth regeneration (Photo courtesy of Thomas Deerinck, National Center for Microscopy and Imaging Research, University of California, San Diego).

Neurite Outgrowth Stimulated by Blocking Acetylcholine Receptor

Neurosciences researchers have found that blocking the muscarinic acetylcholine type 1 receptor (M1R) in neurons promotes neurite outgrowth, which prevents or reverses peripheral neuropathy in cell and rodent models of type I and II diabetes, chemotherapy-induced neuropathy, and HIV. More...
31 Jan 2017
Image: Researchers have discovered new modes of bacteriophage spread (Photo courtesy of Getty Images).

Bacteriophage Infection Mediated by Molecules from Susceptible Organisms

A team of Israeli molecular microbiologists has found that bacteria that are resistant to infection by bacteriophages can lose this resistance when incubated together with susceptible bacteria. More...
26 Jan 2017
Image: Molecular structural model of interleukin 15 (IL-15) (Photo courtesy of Wikimedia Commons).

Activity of Two Interleukins Perpetuate Chronic Autoimmune Conditions

A mouse model of "dry eye disease" was used to demonstrate the link between interleukins 7 and 15 and the pathogenic memory Th17 cells that mediate the autoimmune disease. More...
25 Jan 2017
Image: A confocal microscopic image showing tissue-engineered human stomach tissues from the corpus/fundus region, which produces acid and digestive enzymes (Photo courtesy of Cincinnati Children\'s Hospital Medical Center).

Stem Cell-Generated Stomach Organoids to Boost Gastric Disease Research

Research on gastric diseases will benefit from the development of complex organoid structures containing functional stomach fundic epithelium tissue that were generated from human pluripotent stem cells. More...
24 Jan 2017
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BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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