Features | Partner Sites | Information | LinkXpress
Sign In
Demo Company

Low Dose of Targeted Agent May Enhance Cancer-Destroying Virus Treatment

By BiotechDaily International staff writers
Posted on 22 Jun 2014
Administering low doses of the targeted agent bortezomib with a cancer-killing virus has the potential of enhancing the effectiveness of the virus as treatment for cancer with little added toxicity. This, according to researchers from the Ohio State University Comprehensive Cancer Center (Columbus, USA)-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James). These new findings support the testing of this combination therapy in a clinical trial.

Viruses that are devised to destroy cancer cells—oncolytic viruses—have demonstrated potential in clinical trials for the treatment of brain cancer and other solid tumors. This cell and animal research suggests that mixing low doses of the drug bortezomib with a specific oncolytic virus might substantially enhance the capacity of the virus to kill cancer cells during therapy.

The research was published online May 9, 2014, in the journal Clinical Cancer Research. “These findings pave the way for a treatment strategy for cancer that combines low doses of bortezomib with an oncolytic virus to maximize the efficacy of the virus with little added toxicity,” said lead investigator Balveen Kaur, PhD, professor and vice chair of research, department of neurological surgery and radiation oncology, and a member of the OSUCCC-James Translational Therapeutics Program. “Because bortezomib is already approved by the [US] Food and Drug Administration, a clinical trial could be done relatively quickly to test the effectiveness of the drug-virus combination.”

Bortezomib suppressed the activity of proteasomes, structures in cells that break down and recycle proteins. Prof. Kaur noted that blocking these “cellular recycling plants” triggers a cellular stress response and increases the expression of heat shock proteins. This reaction, which can lead to bortezomib resistance, makes the cells more sensitive to oncolytic virus therapy with little additional toxicity.

For this study, the investigators used a herpes simplex virus-type 1 oncolytic virus. Key technical findings include: (1) One of the overexpressed heat-shock proteins, HSP90, facilitates oncolytic virus replication, enabling the virus to kill more tumor cells; (2) in a glioma model, the combined treatment suppressed tumor growth by 92% in relation to controls and improved survival (six of eight tumors had entirely regressed by day 23 after treatment); (3) lastly, similar outcomes occurred in a head and neck cancer model.

“To our knowledge, this study is the first to show synergy between an oncolytic HSV-1-derived cancer killing virus and bortezomib,” Prof. Kaur concluded. “It offers a novel therapeutic strategy that can be rapidly translated in patients with various solid tumors.”

Related Links:

Ohio State University Comprehensive Cancer Center



view channel
Image: A new catalyst that improved the sensitivity of the standard PSA ELISA test by about 110-fold was made of palladium nanocubes coated with iridium (Photo courtesy of Dr. Xiaohu Xia, Michigan Technological University).

Peroxidase Mimic Outperforms Natural Horseradish Peroxidase in ELISA Test

A test-of-concept study demonstrated that a synthetic catalyst that mimics the action of horseradish peroxidase (HRP) could increase the sensitivity of a colorimetric enzyme-linked immunosorbent assay... Read more

Drug Discovery

view channel
Image: Endoscopic image of a bowel section known as the sigmoid colon afflicted with ulcerative colitis. The internal surface of the colon is blotchy and broken in places (Photo courtesy of Wikimedia Commons).

Orally Delivered Curcumin-Loaded Microparticles Effectively Treat Mouse Model of Ulcerative Colitis

Microparticles (MPs) loaded with the efficient anti-inflammatory agent curcumin were found to effectively treat a mouse model of ulcerative colitis. Ulcerative colitis is a chronic relapsing disease... Read more


view channel

Biopharmaceutical Partners Seek Alternatives to Glucocorticoid Steroid Drugs

Collaboration between American and Japanese biopharmaceutical companies is expected to lead to the development of a new class of small molecule drugs for treatment of hematological and inflammatory diseases. Gencia LLC (Charlottesville, VA, USA) and Takeda Pharmaceutical Company Ltd. (Osaka, Japan) announced the formation... Read more


17 Oct 2015 - 21 Oct 2015
25 Oct 2015 - 29 Oct 2015
16 Nov 2015 - 19 Nov 2015
Copyright © 2000-2015 Globetech Media. All rights reserved.