Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING
BioConferenceLive
JIB

Low Dose of Targeted Agent May Enhance Cancer-Destroying Virus Treatment

By BiotechDaily International staff writers
Posted on 22 Jun 2014
Administering low doses of the targeted agent bortezomib with a cancer-killing virus has the potential of enhancing the effectiveness of the virus as treatment for cancer with little added toxicity. This, according to researchers from the Ohio State University Comprehensive Cancer Center (Columbus, USA)-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James). These new findings support the testing of this combination therapy in a clinical trial.

Viruses that are devised to destroy cancer cells—oncolytic viruses—have demonstrated potential in clinical trials for the treatment of brain cancer and other solid tumors. This cell and animal research suggests that mixing low doses of the drug bortezomib with a specific oncolytic virus might substantially enhance the capacity of the virus to kill cancer cells during therapy.

The research was published online May 9, 2014, in the journal Clinical Cancer Research. “These findings pave the way for a treatment strategy for cancer that combines low doses of bortezomib with an oncolytic virus to maximize the efficacy of the virus with little added toxicity,” said lead investigator Balveen Kaur, PhD, professor and vice chair of research, department of neurological surgery and radiation oncology, and a member of the OSUCCC-James Translational Therapeutics Program. “Because bortezomib is already approved by the [US] Food and Drug Administration, a clinical trial could be done relatively quickly to test the effectiveness of the drug-virus combination.”

Bortezomib suppressed the activity of proteasomes, structures in cells that break down and recycle proteins. Prof. Kaur noted that blocking these “cellular recycling plants” triggers a cellular stress response and increases the expression of heat shock proteins. This reaction, which can lead to bortezomib resistance, makes the cells more sensitive to oncolytic virus therapy with little additional toxicity.

For this study, the investigators used a herpes simplex virus-type 1 oncolytic virus. Key technical findings include: (1) One of the overexpressed heat-shock proteins, HSP90, facilitates oncolytic virus replication, enabling the virus to kill more tumor cells; (2) in a glioma model, the combined treatment suppressed tumor growth by 92% in relation to controls and improved survival (six of eight tumors had entirely regressed by day 23 after treatment); (3) lastly, similar outcomes occurred in a head and neck cancer model.

“To our knowledge, this study is the first to show synergy between an oncolytic HSV-1-derived cancer killing virus and bortezomib,” Prof. Kaur concluded. “It offers a novel therapeutic strategy that can be rapidly translated in patients with various solid tumors.”

Related Links:

Ohio State University Comprehensive Cancer Center



comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: Microcomputed tomography images (top) and histology images (bottom) of the knees of mice fed a very high fat diet containing omega-3 fatty acid supplement (left) or only omega-6 fatty acids (right) after a knee injury. The omega-6 diet showed abnormal bone remodeling and calcified tissue formation in the joint (white arrow). The omega-6 diet also showed significant loss of cartilage (red staining, yellow arrowhead) and increased joint inflammation (Photo courtesy of Duke University).

Dietary Omega-3 Fatty Acids Moderate Severity of Osteoarthritis in a Mouse Model

Researchers working with an osteoarthritis (OA) obese mouse model found that the fat content of the animals' diet contributed more to the development or arrest of OA than did body weight.... Read more

Drug Discovery

view channel
Image: Molecular rendering of the crystal structure of parkin (Photo courtesy of Wikimedia Commons).

Cinnamon Feeding Blocks Development of Parkinson's Disease in Mouse Model

A team of neurological researchers has identified a molecular mechanism by which cinnamon acts to protect neurons from damage caused by Parkinson's disease (PD) in a mouse model of the syndrome.... Read more

Business

view channel

A Surge in IPOs Revitalize Investments for the Global Pharma and Biotech

Anti-infective drugs, oncology, and pharmaceutical contract laboratories attract the most investment up to now. The intensified private equity and venture capital (PEVC) deal activity in the global healthcare industry during the recession years, 2008–2010, witnessed a waning post-2010. However, the decline in deals... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.