Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Events

10 Oct 2016 - 12 Oct 2016
12 Nov 2016 - 16 Nov 2016

Aspirin Use for Heart Disease Prevention May Benefit Those with Coronary Artery Calcium Deposits

By BiotechDaily International staff writers
Posted on 21 May 2014
Print article
Image: Figure A shows the location and angle of the coronary calcium scan image. Figure B is a coronary calcium scan image showing calcifications in a coronary artery (Photo courtesy of the [US] National Heart, Lung, and Blood Institute).
Image: Figure A shows the location and angle of the coronary calcium scan image. Figure B is a coronary calcium scan image showing calcifications in a coronary artery (Photo courtesy of the [US] National Heart, Lung, and Blood Institute).
A recent study found that taking aspirin to prevent heart disease benefits individuals with high coronary artery calcium (CAC) scores but can actually cause damage from bleeding in individuals with low levels of coronary artery calcium.

An individual's CAC score is determined by using computerized tomography (CT) to scan the coronary blood vessels. Calcium deposits show up as bright white spots on the scan.

Investigators at the Minneapolis Heart Institute (MN, USA) monitored 4,229 individuals participating in the Multi-Ethnic Study of Atherosclerosis (MESA) at six centers in the USA. Participants had no known CVD (cardiovascular disease) or diabetes, were not on aspirin therapy, and were followed for approximately seven years.

Results revealed that participants with elevated CAC scores (greater than 100) were two to four times more likely to benefit from aspirin therapy than to be harmed, even if they did not qualify for aspirin use according to current American Heart Association guidelines. Conversely, MESA participants with no calcified plaque (CAC score = zero) were two to four times more likely to be harmed by aspirin use than to benefit.

“We estimate that individuals with significant plaque buildup in the arteries of the heart are much more likely to prevent a heart attack with aspirin use than to suffer a significant bleed,” said first author Dr. Michael D. Miedema, a preventative cardiologist at the Minneapolis Heart Institute. “On the opposite end of the spectrum, if you do not have any calcified plaque, our estimations indicate that use of aspirin would result in more harm than good, even if you have risk factors for heart disease such as high cholesterol or a family history of the disease.”

“A CAC score of zero is associated with a very low risk of having a heart attack. That means individuals with a score of zero may not benefit from preventive medications, such as aspirin as well as the cholesterol-lowering statin medications. Approximately 50% of middle-aged men and women have a CAC score of zero, so there is a potential for this test to personalize the approach to prevention and allow a significant number of patients to avoid preventive medications, but we need further research to verify that routine use of this test is the best option for our patients.”

The study was published in the May 6, 2014, online edition of the journal Circulation: Cardiovascular Quality and Outcomes.

Related Links:

Minneapolis Heart Institute



Print article

Channels

Drug Discovery

view channel
Image: Ginger is the source of a novel class of nanolipid transport vector (Photo courtesy of Georgia State University).

Ginger-Derived Doxorubicin-Loaded Nanovectors as Drug Delivery for Cancer Therapy

A novel type of nanoparticle drug transport system based on lipids isolated from ginger was used to deliver the toxic chemotherapeutic agent doxorubicin (Dox) to colon cancer cells with minimal damage... Read more

Biochemistry

view channel
Image: A space-filling model of the anticonvulsant drug carbamazepine (Photo courtesy of Wikimedia Commons).

Wastewater May Contaminate Crops with Potentially Dangerous Pharmaceuticals

Reclaimed wastewater used to irrigate crops is contaminated with pharmaceutical residues that can be detected in the urine of those who consumed such produce. Investigators at the Hebrew University... Read more

Business

view channel

Collaborative Agreement to Aid in Setting Guidelines for Evaluating Potential Ebola Therapy

Cooperation between an Israeli biopharmaceutical company and medical branches of the US government is designed to set ground rules for continued evaluation of an experimental therapy for Ebola virus disease. RedHill Biopharma Ltd. (Tel Aviv, Israel), a biopharmaceutical company primarily focused on development and c... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.