Features | Partner Sites | Information | LinkXpress
Sign In
PZ HTL SA
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC

Study Initiated to Fight Metastatic Breast Cancer with Innovative Nanoparticles

By BiotechDaily International staff writers
Posted on 10 Feb 2014
A USD 1.3 million grant has been given to an American pharmacy professor to further research a new class of inorganic nanoparticles that target primary cancer, and help control the disease’s metastases and recurrence.

Dr. Wei Lu, the recipient of the US The National Institutes of Health (NIH; Bethesda, MD, USA) grant, is an assistant professor of biomedical and pharmaceutical sciences in the College of Pharmacy at the University of Rhode Island (Kingston, USA), has discovered in his early research efforts that hollow copper sulfide nanoparticles are effective in delivering chemotherapy and heat through a laser that can burn the tumor.

The investigator will be using the four-year NIH grant to further his laboratory research with a focus on breast cancer, the second most frequently diagnosed malignancy in women worldwide. “We are developing a novel cancer therapeutic technology that has several innovative features: biodegradability, multimodality, and simplicity,” said Dr. Lu, who is teaming with pharmacy Prof. Bingfang Yan, a specialist in genetic and environmental factors that combine to control the expression of genes involved in drug response and the cellular switches related to tumor formation. “One nanoparticle can carry hundreds or even thousands of drug molecules to a target like a tumor cell,” he said.

Dr. Lu wants to improve photothermal ablation therapy, a process that uses lasers in cancer treatment. At first, high levels of laser treatments were required to burn and consequently destroy the tumor. Inorganic nanoparticles were introduced, approximately 10 years ago, to this process in animal tests, which provided better absorption of the laser light, generated greater heat, and in turn lowered the laser doses.

However, there are several problems with current nanoparticle-aided photothermal ablation therapy. For example, the current delivery technology does not allow the nanoparticles to be distributed evenly in a tumor, thus the heat generated by the particles is not evenly distributed. As a result, malignancy can continue in the site receiving sub-lethal doses of heat.

Furthermore, some types of nanoparticles, such as gold particles, are difficult for the body to eliminate. “As is the case with surgical removal of a tumor, getting all of the cancer is critical,” Dr. Lu said. “The new nanoparticles provide a three-way punch to the tumor: a more widespread ability in a tumor to distribute heat and burn the tumor, a more efficient and comprehensive way to deliver chemotherapy, and better use of heat to activate the chemotherapeutic agents and immunotherapeutic agents. The new nanotechnology has great potential to eradicate tumors."
 
“Such nanoparticles are introduced intravenously and are absorbed into a tumor,” Dr. Lu concluded. “This study is using near-infrared laser light instead of ultraviolet light or visible light because it penetrates tumor tissue better and has much lower side effects. In addition, these particles are readily degradable in the body, minimizing potential organ toxicity.” 

Related Links:

University of Rhode Island
 


RANDOX LABORATORIES
BIOSIGMA S.R.L.
SLAS - Society for Laboratory Automation and Screening
comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: A 3-dimensional picture reveals how the antibodies in the experimental drug Zmapp bind to Ebola virus (Photo courtesy of the Scripps Research Institute).

Electron Microscope Imaging Shows How Experimental Anti-Ebola Drug Works

Electron microscope imaging has revealed how the experimental drug ZMapp binds to the Ebolavirus and provides insights into how the drug prevents growth of the pathogen. ZMapp, which was developed by... Read more

Drug Discovery

view channel

Omega 3 Found to Improve Behavior in Children with ADHD

Supplements of the fatty acids omega 3 and 6 can help children and adolescents who have a specific kind of have attention deficit hyperactivity disorder (ADHD). Moreover, these findings indicate that a customized cognitive training program can improve problem behavior in children with ADHD. Statistics show that 3%–6%... Read more

Biochemistry

view channel

Blocking Enzyme Switch Turns Off Tumor Growth in T-Cell Acute Lymphoblastic Leukemia

Researchers recently reported that blocking the action of an enzyme “switch” needed to activate tumor growth is emerging as a practical strategy for treating T-cell acute lymphoblastic leukemia. An estimated 25% of the 500 US adolescents and young adults diagnosed yearly with this aggressive disease fail to respond to... Read more

Lab Technologies

view channel

e-Incubator Technology Provides Real-Time Imaging of Bioengineered Tissues in a Controlled Unit

A new e-incubator, an innovative miniature incubator that is compatible with magnetic resonance imaging (MRI), enables scientists to grow tissue-engineered constructs under a controlled setting and to study their growth and development in real time without risk of contamination or damage. Offering the potential to test... Read more

Business

view channel

Two Industry Partnerships Initiated to Fuel Neuroscience Research

Faster, more complex neural research is now attainable by combining technology from two research companies. Blackrock Microsystems, LLC (Salt Lake City, UT, USA), a developer of neuroscience research equipment, announced partnerships with two neuroscience research firms—PhenoSys, GmbH (Berlin, Germany) and NAN Instruments, Ltd.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.