Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH MEDIA
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC

Murine Study Demonstrates Protection Against Allergen-Mediated Airway Pathology

By BiotechDaily International staff writers
Posted on 06 Jan 2014
A new study reveals that exposure to dog-associated household dust results in protection against airway allergen challenges by causing changes in gut microbes.

Researchers at the University of California-San Francisco (UCSF; USA) and the University of Michigan (Ann Arbor, USA), using murine models, succeeded in demonstrating that exposure of mice to dog-associated house dust protects against ovalbumin or cockroach allergen-mediated airway pathology. The protected mice exhibited significant reduction in the total number of airway T cells, down-regulation of Th2-related airway responses, and a reduction of mucin secretion. The researchers then examined the mice to determine why the changes occurred.

The found that the cecal microbiome of the exposed mice was extensively restructured with significant enrichment of, amongst others, Lactobacillus johnsonii. The Lactobacilli protected them against airway allergen challenge or infection with respiratory syncytial virus (RSV) infection, which has been linked with elevated asthma risk when experienced in infancy. The L. johnsonii-mediated protection was associated with significant reductions in the total number and proportion of activated CD11c+/CD11b+ and CD11c+/CD8+ cells. The study was published on December 16, 2013, in the Proceedings of the National Academy of Sciences of the United States of America (PNAS).

“Gut microbiome manipulation represents a promising new therapeutic strategy to protect individuals against both pulmonary infection and allergic airway disease,” said lead author professor Susan Lynch, MD, of the division of gastroenterology at UCSF. “The composition and function of the gut microbiome strongly influence immune reactions and present a novel avenue for development of therapeutics for both allergic asthma and a range of other diseases.”

Exposure of children to dogs in early infancy has been shown to reduce the risk of childhood allergic disease development, and dog ownership is associated with a distinct house dust microbial exposure.

Related Links:

University of California-San Francisco
University of Michigan



Channels

Drug Discovery

view channel
Image: Star-like glial cells in red surround alpha-beta plaques in the cortex of a mouse with a model of Alzheimer\'s disease (Photo courtesy of Strittmatter laboratory/Yale University).

Experimental Cancer Drug Reverses Symptoms in Mouse Model of Alzheimer's Disease

An experimental, but clinically disappointing drug for treatment of cancer has been found to be extremely effective in reversing the symptoms of Alzheimer's disease (AD) in a mouse model.... Read more

Business

view channel

NanoString and MD Anderson Collaborate on Development of Novel Multi-Omic Expression Profiling Assays for Cancer

The University of Texas MD Anderson Cancer Center (Houston, TX, USA) and NanoString Technologies, Inc. (Seattle, WA, USA) will partner on development of a revolutionary new type of assay—simultaneously profiling gene and protein expression, initially aiming to discover and validate biomarker signatures for immuno-oncology... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.