Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING
JIB
BioConferenceLive

Specialized Stem Cells Demonstrate Efficacy for Graft versus Host Disease Therapy

By BiotechDaily International staff writers
Posted on 15 Oct 2013
Image: Pluristem PLacental eXpanded (PLX) cell bioreactor (Photo courtesy of Pluristem Therapeutics).
Image: Pluristem PLacental eXpanded (PLX) cell bioreactor (Photo courtesy of Pluristem Therapeutics).
In a preclinical study, specially grown and expanded stem cells demonstrated efficacy for the treatment of Graft versus Host Disease (GvHD) following bone marrow transplantation in mice. A clinical path is now being investigated.

The study was performed using “PLacental eXpanded” (PLX) cells from Pluristem Therapeutics Inc. (Haifa, Israel), a developer of cell-based therapies by expanding noncontroversial placental-derived mesenchymal stem cells via a proprietary 3D micro-environmental process, named PluriX, into therapeutics for a variety of disorders. PLX cells provide a drug delivery platform that releases a cocktail of therapeutic proteins in response to a host of local and systemic inflammatory and ischemic diseases. They require no tissue matching prior to administration, and thereby addressing part of the global shortfall of matched tissue for bone marrow transplantation (BMT).

In the study conducted at the Department of Bone Marrow Transplantation of the Hebrew University, Hadassah Medical Center (Jerusalem, Israel), mice underwent total body irradiation and after 24 hours received a semi-allogeneic BMT. PLX cells, or the same volumes of the control vehicle, were then injected IV (intravenous) or IM (intramuscular) into the mice concurrently with the BMT (day 0, about 20 hours after irradiation) and 5 days postirradiation. PLX markedly reduced the GvHD score, comprised of weight loss, diarrhea, skin and fur integrity, and survival. This significant (p < 0.05) improvement in the GvHD score occurred in both the IV and IM treatment groups 42 days after transplantation. Moreover, histological examination of the liver revealed reduced hepatic lymphocyte infiltration (a marker for the severity of GvHD) occurring in the PLX-treated groups, also without preference to administration route (IV or IM).

“Based on the results of this preclinical study suggesting our PLX cells may be effective in GvHD, we are pleased with the interest of leading medical institutions to use our PLX cells and will consider a cooperation to advance into a clinical program for this indication,” said Zami Aberman, Chairman and CEO of Pluristem; “[...] this study also gives Pluristem another data point demonstrating PLX cells do not have to be given intravenously to obtain a systemic effect.” This study marks the second time that IM administration of PLX cells has demonstrated a systemic effect with efficacy in a hematological disease and the fourth time when preclinical animal models for other indications are included. Systemic, beneficial effects were also noted in three patients given (under compassionate use) PLX cells IM for bone marrow failure.

Related Links:

Pluristem Therapeutics
Hebrew University – Hadassah Medical Center



comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: Microcomputed tomography images (top) and histology images (bottom) of the knees of mice fed a very high fat diet containing omega-3 fatty acid supplement (left) or only omega-6 fatty acids (right) after a knee injury. The omega-6 diet showed abnormal bone remodeling and calcified tissue formation in the joint (white arrow). The omega-6 diet also showed significant loss of cartilage (red staining, yellow arrowhead) and increased joint inflammation (Photo courtesy of Duke University).

Dietary Omega-3 Fatty Acids Moderate Severity of Osteoarthritis in a Mouse Model

Researchers working with an osteoarthritis (OA) obese mouse model found that the fat content of the animals' diet contributed more to the development or arrest of OA than did body weight.... Read more

Drug Discovery

view channel
Image: Molecular rendering of the crystal structure of parkin (Photo courtesy of Wikimedia Commons).

Cinnamon Feeding Blocks Development of Parkinson's Disease in Mouse Model

A team of neurological researchers has identified a molecular mechanism by which cinnamon acts to protect neurons from damage caused by Parkinson's disease (PD) in a mouse model of the syndrome.... Read more

Business

view channel

A Surge in IPOs Revitalize Investments for the Global Pharma and Biotech

Anti-infective drugs, oncology, and pharmaceutical contract laboratories attract the most investment up to now. The intensified private equity and venture capital (PEVC) deal activity in the global healthcare industry during the recession years, 2008–2010, witnessed a waning post-2010. However, the decline in deals... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.