Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Flavonoids Kill Human Pancreatic Cancer Cells

By BiotechDaily International staff writers
Posted on 26 Aug 2013
Print article
Flavonoids in celery, artichokes, and especially Mexican oregano contain flavonoids that kill human pancreatic cancer cells by enzymatic inhibition, according to a new study.

Two researchers at the University of Illinois (UIC; Chicago, IL, USA) examined the inhibitory effects of flavonoids, limonoids, phenolic acids, and ascorbic acid citrus fruit bioactive compounds on BxPC-3 and PANC-1 human pancreatic cancer cells in vitro, focusing on the antiproliferative mechanism of action of the flavonoid apigenin as related to the glycogen synthase kinase-3β (GSK-3β) nuclear factor kappa B signaling pathway.

The researchers found that apigenin inhibited the GSK-3β enzymatic pathway, leading to a decrease in the production of antiapoptotic genes in the pancreatic cancer cells, thus encouraging the cancer cells to self-destruct via apoptosis. In one of the cancer cell lines, the percentage of cells undergoing apoptosis went from 8.4% in cells that had not been treated with the flavonoid to 43.8% in cells that had been treated with a 50-micromolar dose. Treatment with the flavonoid also modified gene expression, causing upregulation of certain genes associated with pro-inflammatory cytokines such interleukin 17. The study was published on August 13, 2013, in Molecular Nutrition and Food Research.

“Apigenin alone induced cell death in two aggressive human pancreatic cancer cell lines. But we received the best results when we pretreated cancer cells with apigenin for 24 hours, then applied the chemotherapeutic drug gemcitabine for 36 hours,” said study coauthor professor Elvira de Mejia, PhD. “Pancreatic cancer patients would probably not be able to eat enough flavonoid-rich foods to raise blood plasma levels of the flavonoid to an effective level. But scientists could design drugs that would achieve those concentrations.”

“The trick seemed to be using the flavonoids as a pretreatment instead of applying them and the chemotherapeutic drug simultaneously. Even though the topic is still controversial, our study indicated that taking antioxidant supplements on the same day as chemotherapeutic drugs may negate the effect of those drugs,” added coauthor Jodee Johnson, PhD. “That happens because flavonoids can act as antioxidants. One of the ways that chemotherapeutic drugs kill cells is based on their pro-oxidant activity, meaning that flavonoids and chemotherapeutic drugs may compete with each other when they're introduced at the same time.”

Flavonoids are a class of plant secondary metabolites that may modify allergens, viruses, and carcinogens, and demonstrate significant antioxidant activity in vitro that may be stronger than those of vitamin C and E. However, inside the human body, they have little or no direct antioxidant value, since flavonoids are poorly absorbed (less than 5%), with most of what is absorbed being quickly metabolized and excreted.

Related Links:

University of Illinois




Print article

Channels

Genomics/Proteomics

view channel
Image: The green-labeled cells show a basal cell carcinoma in mouse tail epidermis derived from a single mutant stem cell and expanding out of the normal epidermis stained in red (Photo courtesy of Adriana Sánchez-Danés, Université Libre de Bruxelles).

Stem Cells Not Progenitors Can Trigger Skin Cancer Growth

Cancer researchers have discovered that stem cells can initiate development of malignant skin tumors, while progenitor cells are limited to triggering only benign growths. A progenitor cell is similar... Read more

Biochemistry

view channel
Image: A space-filling model of the anticonvulsant drug carbamazepine (Photo courtesy of Wikimedia Commons).

Wastewater May Contaminate Crops with Potentially Dangerous Pharmaceuticals

Reclaimed wastewater used to irrigate crops is contaminated with pharmaceutical residues that can be detected in the urine of those who consumed such produce. Investigators at the Hebrew University... Read more

Lab Technologies

view channel
Image: A 3D nanofiber net formed by the supergelators to trap oil molecules (Photo courtesy of IBN at A*STAR / Institute of Bioengineering and Nanotechnology).

Effective Cleanup with Smart Material That Forms Oil-Trapping Net

Researchers have developed supergelators – an organic oil-scavenging material that rapidly forms a 3D net to trap oil molecules, gelatinizing into solidified masses that can be more easily removed from... Read more

Business

view channel

Sartorius Acquires US Start-up ViroCyt

Sartorius AG (Göttingen, Germany), a pharmaceutical and laboratory equipment provider, has acquired ViroCyt Incorporated (Broomfield, CO, USA), a start-up in the field of rapid virus quantification, in a deal valued at approximately USD 16 million. ViroCyt’s automated platform integrates instruments, software and reagents... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.