Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH MEDIA
GLOBETECH PUBLISHING LLC

Curbing Sugar Intake May Slash Risk of Cancer or Progression in the Diabetic and Obese

By BiotechDaily International staff writers
Posted on 14 Aug 2013
By blocking dietary sugar and its activity in tumor cells, investigators believe that people may be able to reduce their cancer risk and progression.

The study, conducted in fruit flies by researchers from the Icahn School of Medicine at Mount Sinai (New York, NY, USA) and published August 1, 2013, in the journal Cell, provides insight as to why metabolism-related diseases such as diabetes or obesity are associated with certain types of cancer, including breast, pancreatic, liver, and colon cancers.

Ross Cagan, PhD, professor of developmental and regenerative biology at Mount Sinai, has developed a cancer model in the fruit fly Drosophila that allows scientists to evaluate diseases in the perspective of the whole animal and numerous genetic targets, instead of just looking at the link of one gene to one disease. Dr. Cagan used fruit flies in his research to determine the effects of diet and insulin resistance on cancer progression.

“Previous research has established a strong correlation between metabolic diseases and pancreatic, breast, liver, and colon cancers, but we have not determined how tumors grow so aggressively in this environment if they do not have the energy provided by glucose,” said Dr. Cagan, who is also associate dean of the Graduate School of Biomedical Sciences at Mount Sinai. “Using our fruit fly model, we discovered how tumors overcome insulin resistance in the body and turn metabolic dysfunction to their advantage.”

Dr. Cagan and his team modified fruit flies to express Ras and Src, two key oncogenes, which resulted in the development of small head tumors. Next, they fed the flies with a high-sugar diet that triggered insulin resistance. They discovered that high dietary sugar acts together with Ras and Src to increase insulin sensitivity specifically in tumor cells. By increasing the signaling of an important pathway called Wingless/Wnt, they increased tumor cells’ insulin receptors to further promote insulin sensitivity. This cascade of activity altered these small, weak tumors and caused them to begin growing aggressively.

Armed with three new drug targets—glucose, the Ras/Src oncogenes, and Wingless/Wnt signaling—Dr. Cagan and his coworkers identified compounds that can block the process. They treated the flies with acarbose, a drug for diabetes treatment; a compound called AD81; and an agent called pyrvinium. Acarbose blocked sugar conversion to glucose; AD81 blocked Ras/Src and caused cell death; and pyrvinium suppressed Wingless/Wnt signaling. Combined, this blend of drugs considerably reduced tumor size and progression.

“Our study shows that sugar activates oncogenes in the tumor, which then promote insulin sensitivity, meaning that the exorbitant glucose levels in the blood pour into the tumor, having nowhere else to go in the insulin-resistant body,” said Dr. Cagan. “We have identified a three-drug combination that stops this signaling activity and tumor growth in its tracks, without affecting normal cell function.”

In the next phase, the researcher plans to find out whether the same cascade of occurrences is happening in humans with insulin resistance using tumor samples. Based on those findings, Dr. Cagan and his team will evaluate substances that can manipulate this oncogene/sugar cascade.

Related Links:

Icahn School of Medicine at Mount Sinai



Channels

Drug Discovery

view channel
Image: Star-like glial cells in red surround alpha-beta plaques in the cortex of a mouse with a model of Alzheimer\'s disease (Photo courtesy of Strittmatter laboratory/Yale University).

Experimental Cancer Drug Reverses Symptoms in Mouse Model of Alzheimer's Disease

An experimental, but clinically disappointing drug for treatment of cancer has been found to be extremely effective in reversing the symptoms of Alzheimer's disease (AD) in a mouse model.... Read more

Biochemistry

view channel
Image:  Model depiction of a novel cellular mechanism by which regulation of cryptochromes Cry1 and Cry2 enables coordination of a protective transcriptional response to DNA damage caused by genotoxic stress (Photo courtesy of the journal eLife, March 2015, Papp SJ, Huber AL, et al.).

Two Proteins Critical for Circadian Cycles Protect Cells from Mutations

Scientists have discovered that two proteins critical for maintaining healthy day-night cycles also have an unexpected role in DNA repair and protecting cells against genetic mutations that could lead... Read more

Business

view channel

NanoString and MD Anderson Collaborate on Development of Novel Multi-Omic Expression Profiling Assays for Cancer

The University of Texas MD Anderson Cancer Center (Houston, TX, USA) and NanoString Technologies, Inc. (Seattle, WA, USA) will partner on development of a revolutionary new type of assay—simultaneously profiling gene and protein expression, initially aiming to discover and validate biomarker signatures for immuno-oncology... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.