Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
PZ HTL SA
GLOBETECH PUBLISHING LLC

Suppressing HIV Infection with Soybean Compound

By BiotechDaily International staff writers
Posted on 14 Aug 2013
A compound found in soybeans may become an effective HIV treatment, which could eliminate the drug resistance problems faced by current therapies, according to new research.

Genistein, derived from soybeans and other plants, shows potential in suppressing the HIV infection, according to Dr. Yuntao Wu, an infectious diseases and the department of molecular and microbiology professor with the George Mason University (Fairfax, VA, USA)-based US National Center for Biodefense.

Nevertheless, that does not mean individuals should begin eating large amounts of soy products. “Although genistein is rich in several plants such as soybeans, it is still uncertain whether the amount of genistein we consume from eating soy is sufficient to inhibit HIV,” Dr. Wu said.

Genistein functions by blocking the communication from a cell’s surface sensors to its insides and is known as a tyrosine kinase inhibitor. These sensors, located on the cell’s surface, tell the cell about its environment and also communicate with other cells. HIV uses some of these surface sensors to trick the cell to send signals inside. These signals change cell structure so that the virus can get inside and spread infection.

However, genistein blocks the signal and stops HIV from finding a way inside the cell. It takes a different approach than the conventional antiretroviral drug used to suppress HIV. “Instead of directly acting on the virus, genistein interferes with the cellular processes that are necessary for the virus to infect cells,” Dr. Wu noted. “Thus, it makes the virus more difficult to become resistant to the drug. Our study is currently it its early stage. If clinically proven effective, genistein may be used as a complement treatment for HIV infection.”

Dr. Wu sees possibilities in this plant-based approach, which may address drug toxicity issues as well. Because genistein is plant-derived, it may be able to sidestep drug toxicity, a common byproduct of the daily and lifelong pharmaceutical regimen faced by patients with HIV to keep the disease at bay, according to Dr. Wu. Typically, patients take a combination of multiple drugs to inhibit the virus. The frequency can lead to drug toxicity. Furthermore, HIV mutates and becomes drug-resistant.

Dr. Wu and his team are now looking for ways to determine how much genistein is required to inhibit HIV. Because there is a possibility that plants may not have high enough levels, this agent would need to be refined and further developed.

Related Links:

George Mason University




comments powered by Disqus

Channels

Genomics/Proteomics

view channel

New Program Encourages Wide Distribution of Genomic Data

A new data sharing program allows genomics researchers and practitioners to analyze, visualize, and share raw sequence data for individual patients or across populations straight from a local browser. The sequencing revolution is providing the raw data required to identify the genetic variants underlying rare diseases... Read more

Drug Discovery

view channel
Image: The nano-cocoon drug delivery system is biocompatible, specifically targets cancer cells, can carry a large drug load, and releases the drugs very quickly once inside the cancer cell. Ligands on the surface of the \"cocoon\" trick cancer cells into consuming it. Enzymes (the “worms\" in this image) inside the cocoon are unleashed once inside the cell, destroying the cocoon and releasing anticancer drugs into the cell (Photo courtesy of Dr. Zhen Gu, North Carolina State University).

Novel Anticancer Drug Delivery System Utilizes DNA-Based Nanocapsules

A novel DNA-based drug delivery system minimizes damage to normal tissues by utilizing the acidic microenvironment inside cancer cells to trigger the directed release of the anticancer drug doxorubicin (DOX).... Read more

Lab Technologies

view channel

Experimental Physicists Find Clues into How Radiotherapy Kills Cancer Cells

A new discovery in experimental physics has implications for a better determination of the process in which radiotherapy destroys cancer cells. Dr. Jason Greenwood from Queen’s University Belfast (Ireland) Center for Plasma Physics collaborated with scientists from Italy and Spain on the work on electrons, and published... Read more

Business

view channel

Interest in Commercial Applications for Proteomics Continues to Grow

Increasing interest in the field of proteomics has led to a series of agreements between private proteomic companies and academic institutions as well as deals between pharmaceutical companies and novel proteomics innovator biotech companies. Proteomics is the study of the structure and function of proteins.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.