Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Events

06 Jun 2016 - 09 Jun 2016
22 Jun 2016 - 24 Jun 2016
04 Jul 2016 - 06 Jul 2016

Suppressing HIV Infection with Soybean Compound

By BiotechDaily International staff writers
Posted on 14 Aug 2013
Print article
A compound found in soybeans may become an effective HIV treatment, which could eliminate the drug resistance problems faced by current therapies, according to new research.

Genistein, derived from soybeans and other plants, shows potential in suppressing the HIV infection, according to Dr. Yuntao Wu, an infectious diseases and the department of molecular and microbiology professor with the George Mason University (Fairfax, VA, USA)-based US National Center for Biodefense.

Nevertheless, that does not mean individuals should begin eating large amounts of soy products. “Although genistein is rich in several plants such as soybeans, it is still uncertain whether the amount of genistein we consume from eating soy is sufficient to inhibit HIV,” Dr. Wu said.

Genistein functions by blocking the communication from a cell’s surface sensors to its insides and is known as a tyrosine kinase inhibitor. These sensors, located on the cell’s surface, tell the cell about its environment and also communicate with other cells. HIV uses some of these surface sensors to trick the cell to send signals inside. These signals change cell structure so that the virus can get inside and spread infection.

However, genistein blocks the signal and stops HIV from finding a way inside the cell. It takes a different approach than the conventional antiretroviral drug used to suppress HIV. “Instead of directly acting on the virus, genistein interferes with the cellular processes that are necessary for the virus to infect cells,” Dr. Wu noted. “Thus, it makes the virus more difficult to become resistant to the drug. Our study is currently it its early stage. If clinically proven effective, genistein may be used as a complement treatment for HIV infection.”

Dr. Wu sees possibilities in this plant-based approach, which may address drug toxicity issues as well. Because genistein is plant-derived, it may be able to sidestep drug toxicity, a common byproduct of the daily and lifelong pharmaceutical regimen faced by patients with HIV to keep the disease at bay, according to Dr. Wu. Typically, patients take a combination of multiple drugs to inhibit the virus. The frequency can lead to drug toxicity. Furthermore, HIV mutates and becomes drug-resistant.

Dr. Wu and his team are now looking for ways to determine how much genistein is required to inhibit HIV. Because there is a possibility that plants may not have high enough levels, this agent would need to be refined and further developed.

Related Links:

George Mason University




Print article

Channels

Genomics/Proteomics

view channel
Image: A dark field photomicrograph showing the spirochete bacterium Borrelia burgdorferi, the pathogen responsible for causing Lyme disease (Photo courtesy of the CDC).

Statins May Help Block Transmission of Lyme Disease

A recent study found that treatment with cholesterol-lowering statins reduced the number of Borrelia burgdorferi bacteria in rodents, which helped to block transmission of Lyme disease. Lyme disease... Read more

Drug Discovery

view channel

Experimental Small-Molecule Anticancer Drug Blocks RAS-binding Domains

The experimental small-molecule anticancer drug rigosertib was shown to block tumor growth by acting as an RAS-mimetic and interacting with the RAS binding domains of RAF kinases, resulting in their inability to bind to RAS, which inhibited the RAS-RAF-MEK pathway. Oncogenic activation of RAS genes due to point mutations... Read more

Biochemistry

view channel
Image: A space-filling model of the anticonvulsant drug carbamazepine (Photo courtesy of Wikimedia Commons).

Wastewater May Contaminate Crops with Potentially Dangerous Pharmaceuticals

Reclaimed wastewater used to irrigate crops is contaminated with pharmaceutical residues that can be detected in the urine of those who consumed such produce. Investigators at the Hebrew University... Read more

Lab Technologies

view channel

Huge Modifiable Biomedical Database to Be Available on the Wikidata Site

Genome researchers are exploiting the power of the open Internet community Wikipedia database to create a comprehensive resource for geneticists, molecular biologists, and other interested life scientists. While efficiency in generating scientific data improves almost daily, applying meaningful relationships between... Read more

Business

view channel

European Biotech Agreement to Promote Antigen-Drug Conjugation Technology

Two European biotech companies have joined forces to exploit and commercialize an innovative, site-specific ADC (antigen-drug conjugate) conjugation technology. ProBioGen (Berlin, Germany), a company specializing in the development and manufacture of complex glycoproteins and Eucodis Bioscience (Vienna, Austria), a... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.