Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH MEDIA
GLOBETECH PUBLISHING LLC

Nematode Infection Controls Obesity and Modulates Body Weight and Metabolism

By BiotechDaily International staff writers
Posted on 09 May 2013
In an interesting combination of low and high technology approaches to the control and treatment of obesity, a recent study suggested that infection with parasitic nematodes (roundworms) could suppress the chronic inflammation associated with obesity and modulate body weight and metabolism.

Obesity is associated with a chronic low-grade inflammation characterized by increased levels of proinflammatory cytokines that are implicated in metabolic dysfunction. Nematode infection, which elevates host immune Th2-cells and related type two cytokines, has been used in ancient medicine and is currently under clinical investigation for treatment for diseases associated with the relevant cytokines, including inflammatory bowel disease, multiple sclerosis, and allergies

Investigators at the University of Maryland School of Medicine (Baltimore, USA) examined the possibility of using nematode infection to treat obesity. They worked with several strains of mice that were fed normal or high-fat diets.

They reported in the March 18, 2013, online edition of the journal Infection and Immunity that normal size mice infected with the nematode Nippostrongyrus brasiliensis fed a high-fat diet gained 15% percent less weight than control animals that were not infected. Mice that were already obese when infected lost roughly 13% of their body weight within 10 days. Infected animals were found to have decreased fasting blood glucose levels and reduced incidence of fatty liver disease.

"The levels of insulin and leptin also dropped, indicating that the mice restored their sensitivities to both hormones," said senior author Dr. Aiping Zhao, associate professor of radiation oncology at the University of Maryland School of Medicine. "Leptin moderates appetite. As with too much insulin, too high a level of leptin results in insensitivity, thus contributing to obesity and metabolic syndrome."

Related Links:

University of Maryland School of Medicine



Channels

Drug Discovery

view channel
Image: Star-like glial cells in red surround alpha-beta plaques in the cortex of a mouse with a model of Alzheimer\'s disease (Photo courtesy of Strittmatter laboratory/Yale University).

Experimental Cancer Drug Reverses Symptoms in Mouse Model of Alzheimer's Disease

An experimental, but clinically disappointing drug for treatment of cancer has been found to be extremely effective in reversing the symptoms of Alzheimer's disease (AD) in a mouse model.... Read more

Biochemistry

view channel
Image:  Model depiction of a novel cellular mechanism by which regulation of cryptochromes Cry1 and Cry2 enables coordination of a protective transcriptional response to DNA damage caused by genotoxic stress (Photo courtesy of the journal eLife, March 2015, Papp SJ, Huber AL, et al.).

Two Proteins Critical for Circadian Cycles Protect Cells from Mutations

Scientists have discovered that two proteins critical for maintaining healthy day-night cycles also have an unexpected role in DNA repair and protecting cells against genetic mutations that could lead... Read more

Business

view channel

NanoString and MD Anderson Collaborate on Development of Novel Multi-Omic Expression Profiling Assays for Cancer

The University of Texas MD Anderson Cancer Center (Houston, TX, USA) and NanoString Technologies, Inc. (Seattle, WA, USA) will partner on development of a revolutionary new type of assay—simultaneously profiling gene and protein expression, initially aiming to discover and validate biomarker signatures for immuno-oncology... Read more
 

Events

21 Apr 2015 - 23 Apr 2015
21 Apr 2015 - 23 Apr 2015
Copyright © 2000-2015 Globetech Media. All rights reserved.