Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Events

25 May 2016 - 27 May 2016
06 Jun 2016 - 09 Jun 2016
22 Jun 2016 - 24 Jun 2016

Infrared Light Causes Organic Nanoparticles to Heat Up and Cook Cancer Cells

By BiotechDaily International staff writers
Posted on 06 Dec 2012
Print article
Novel organic nanoparticles that generate heat when exposed to infrared light effectively killed colorectal cancer cells in a cell-culture model system.

Investigators at Wake Forest Baptist Medical Center (Winston-Salem, NC, USA) developed conjugated polymer nanoparticles (PNs) consisting of 2-ethylhexyl cyclopentadithiophene copolymerized with 2,1,3-benzothiadiazole (for nano-PCPDTBT) or 2,1,3-benzoselenadiazole (for nano-PCPDTBSe). The PNs were stable in aqueous media and showed no significant toxicity up to one mg/mL. Upon exposure to infrared light at 808 nm, the PNs generated temperatures above 50 degrees Celsius.

Experiments were carried out to test the effect of the PNs on cultures of RKO and HCT116 colorectal cancer cells.

Results published in the October 5, 2012, online edition of the journal Macromolecular Bioscience revealed that exposure to infrared light for five minutes killed more than 80% of the cells at nano-PCPDTBSe concentrations above 100 micrograms/mL, while at concentrations above 62 micrograms/mL for nano-PCPDTBT, more than 90% of cells were killed.

“The results of this study demonstrate how new medical advancements are being developed from materials science research,” said senior author Dr. Nicole H. Levi-Polyachenko, assistant professor of plastic and reconstructive surgery at Wake Forest Baptist Medical Center. “There is a lot more research that needs to be done so that these new nanoparticles can be used safely in patients, but the field of electrically-conductive polymers is broad and offers many opportunities to develop safe, organic nanoparticles for generating heat locally in a tissue. We are very enthusiastic about future medical applications using these new nanoparticles, including an alternative approach for treating colorectal cancer.”

Related Links:
Wake Forest Baptist Medical Center


Print article

Channels

Genomics/Proteomics

view channel
Image: Follicular helper T-cells (TFH cells, shown in blue) play a crucial role in the maturation of antibody-producing B-cells (shown in green). Activated B-cells give rise germinal centers (shown in red), where mature B-cells proliferate and produce highly specific antibodies against pathogens. Top left: normal germinal center in a mouse tonsil. All others: Germinal centers fail to form when the interaction between ICOS and TBK1 is interrupted (Photo courtesy of Dr. Kok-Fai Kong, La Jolla Institute for Allergy and Immunology).

Molecular Pathway Controlling High-affinity Antibody Production Identified

A molecular pathway has been identified that controls formation of follicular helper T-cells (TFH cells) germinal centers and production of high-affinity antibodies through interaction with the inducible... Read more

Drug Discovery

view channel

Experimental Small-Molecule Anticancer Drug Blocks RAS-binding Domains

The experimental small-molecule anticancer drug rigosertib was shown to block tumor growth by acting as an RAS-mimetic and interacting with the RAS binding domains of RAF kinases, resulting in their inability to bind to RAS, which inhibited the RAS-RAF-MEK pathway. Oncogenic activation of RAS genes due to point mutations... Read more

Biochemistry

view channel
Image: A space-filling model of the anticonvulsant drug carbamazepine (Photo courtesy of Wikimedia Commons).

Wastewater May Contaminate Crops with Potentially Dangerous Pharmaceuticals

Reclaimed wastewater used to irrigate crops is contaminated with pharmaceutical residues that can be detected in the urine of those who consumed such produce. Investigators at the Hebrew University... Read more

Lab Technologies

view channel

Huge Modifiable Biomedical Database to Be Available on the Wikidata Site

Genome researchers are exploiting the power of the open Internet community Wikipedia database to create a comprehensive resource for geneticists, molecular biologists, and other interested life scientists. While efficiency in generating scientific data improves almost daily, applying meaningful relationships between... Read more

Business

view channel

European Biotech Agreement to Promote Antigen-Drug Conjugation Technology

Two European biotech companies have joined forces to exploit and commercialize an innovative, site-specific ADC (antigen-drug conjugate) conjugation technology. ProBioGen (Berlin, Germany), a company specializing in the development and manufacture of complex glycoproteins and Eucodis Bioscience (Vienna, Austria), a... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.