Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING
GLOBETECH PUBLISHING
PZ HTL SA

Infrared Light Causes Organic Nanoparticles to Heat Up and Cook Cancer Cells

By BiotechDaily International staff writers
Posted on 06 Dec 2012
Novel organic nanoparticles that generate heat when exposed to infrared light effectively killed colorectal cancer cells in a cell-culture model system.

Investigators at Wake Forest Baptist Medical Center (Winston-Salem, NC, USA) developed conjugated polymer nanoparticles (PNs) consisting of 2-ethylhexyl cyclopentadithiophene copolymerized with 2,1,3-benzothiadiazole (for nano-PCPDTBT) or 2,1,3-benzoselenadiazole (for nano-PCPDTBSe). The PNs were stable in aqueous media and showed no significant toxicity up to one mg/mL. Upon exposure to infrared light at 808 nm, the PNs generated temperatures above 50 degrees Celsius.

Experiments were carried out to test the effect of the PNs on cultures of RKO and HCT116 colorectal cancer cells.

Results published in the October 5, 2012, online edition of the journal Macromolecular Bioscience revealed that exposure to infrared light for five minutes killed more than 80% of the cells at nano-PCPDTBSe concentrations above 100 micrograms/mL, while at concentrations above 62 micrograms/mL for nano-PCPDTBT, more than 90% of cells were killed.

“The results of this study demonstrate how new medical advancements are being developed from materials science research,” said senior author Dr. Nicole H. Levi-Polyachenko, assistant professor of plastic and reconstructive surgery at Wake Forest Baptist Medical Center. “There is a lot more research that needs to be done so that these new nanoparticles can be used safely in patients, but the field of electrically-conductive polymers is broad and offers many opportunities to develop safe, organic nanoparticles for generating heat locally in a tissue. We are very enthusiastic about future medical applications using these new nanoparticles, including an alternative approach for treating colorectal cancer.”

Related Links:
Wake Forest Baptist Medical Center


comments powered by Disqus

Channels

Genomics/Proteomics

view channel

Researchers Discover New Data on Protein Kinase A

By employing X-rays and neutron beams, a team of researchers have gleaned new information about protein kinase A (PKA), an omnipresent master control protein that helps regulate basic cellular functions such as energy consumption and interactions with neurotransmitters, hormones, and drugs. The scientists who conducted... Read more

Drug Discovery

view channel

Molecule in Green Tea Used as Carrier for Anticancer Proteins

A molecule that is a key ingredient in green tea can be employed as a carrier for anticancer proteins, forming a stable and effective therapeutic nanocomplex. This new discovery could help to construct better drug-delivery systems. Some cancer treatments depend on medication comprising the therapeutic drug and a carrier... Read more

Business

view channel

Interest in Commercial Applications for Proteomics Continues to Grow

Increasing interest in the field of proteomics has led to a series of agreements between private proteomic companies and academic institutions as well as deals between pharmaceutical companies and novel proteomics innovator biotech companies. Proteomics is the study of the structure and function of proteins.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.