Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC
PZ HTL SA

Infrared Light Causes Organic Nanoparticles to Heat Up and Cook Cancer Cells

By BiotechDaily International staff writers
Posted on 06 Dec 2012
Novel organic nanoparticles that generate heat when exposed to infrared light effectively killed colorectal cancer cells in a cell-culture model system.

Investigators at Wake Forest Baptist Medical Center (Winston-Salem, NC, USA) developed conjugated polymer nanoparticles (PNs) consisting of 2-ethylhexyl cyclopentadithiophene copolymerized with 2,1,3-benzothiadiazole (for nano-PCPDTBT) or 2,1,3-benzoselenadiazole (for nano-PCPDTBSe). The PNs were stable in aqueous media and showed no significant toxicity up to one mg/mL. Upon exposure to infrared light at 808 nm, the PNs generated temperatures above 50 degrees Celsius.

Experiments were carried out to test the effect of the PNs on cultures of RKO and HCT116 colorectal cancer cells.

Results published in the October 5, 2012, online edition of the journal Macromolecular Bioscience revealed that exposure to infrared light for five minutes killed more than 80% of the cells at nano-PCPDTBSe concentrations above 100 micrograms/mL, while at concentrations above 62 micrograms/mL for nano-PCPDTBT, more than 90% of cells were killed.

“The results of this study demonstrate how new medical advancements are being developed from materials science research,” said senior author Dr. Nicole H. Levi-Polyachenko, assistant professor of plastic and reconstructive surgery at Wake Forest Baptist Medical Center. “There is a lot more research that needs to be done so that these new nanoparticles can be used safely in patients, but the field of electrically-conductive polymers is broad and offers many opportunities to develop safe, organic nanoparticles for generating heat locally in a tissue. We are very enthusiastic about future medical applications using these new nanoparticles, including an alternative approach for treating colorectal cancer.”

Related Links:
Wake Forest Baptist Medical Center


SLAS - Society for Laboratory Automation and Screening
RANDOX LABORATORIES
BIOSIGMA S.R.L.
comments powered by Disqus

Channels

Drug Discovery

view channel

Omega 3 Found to Improve Behavior in Children with ADHD

Supplements of the fatty acids omega 3 and 6 can help children and adolescents who have a specific kind of have attention deficit hyperactivity disorder (ADHD). Moreover, these findings indicate that a customized cognitive training program can improve problem behavior in children with ADHD. Statistics show that 3%–6%... Read more

Biochemistry

view channel

Blocking Enzyme Switch Turns Off Tumor Growth in T-Cell Acute Lymphoblastic Leukemia

Researchers recently reported that blocking the action of an enzyme “switch” needed to activate tumor growth is emerging as a practical strategy for treating T-cell acute lymphoblastic leukemia. An estimated 25% of the 500 US adolescents and young adults diagnosed yearly with this aggressive disease fail to respond to... Read more

Lab Technologies

view channel
Image: On target: When researchers introduced nanobodies they made to cells engineered to express a tagged version of a protein in skeletal fibers known as tubulin (red), the nanobodies latched on. The cells above have recently divided (Photo courtesy of Rockefeller University).

Turning Antibodies into Precisely Tuned Nanobodies

New technology has the potential to create nanobodies making them much more accessible than antibodies for all sorts of research. Antibodies control the process of recognizing and zooming in on molecular... Read more

Business

view channel

Two Industry Partnerships Initiated to Fuel Neuroscience Research

Faster, more complex neural research is now attainable by combining technology from two research companies. Blackrock Microsystems, LLC (Salt Lake City, UT, USA), a developer of neuroscience research equipment, announced partnerships with two neuroscience research firms—PhenoSys, GmbH (Berlin, Germany) and NAN Instruments, Ltd.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.