Features | Partner Sites | Information | LinkXpress
Sign In
PZ HTL SA
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC

Hidden Vitamin in Beer May Prevent Obesity

By BiotechDaily International staff writers
Posted on 18 Jun 2012
A new study suggests that nicotinamide riboside (NR), a molecule found in beer and milk, could indirectly influence the activity of cell metabolism, thus preventing weight gain and diabetes, and improving muscular performance.

Researchers at the Federal Polytechnic School of Lausanne (EPFL; Switzerland) and other institutions conducted a study in mice to evaluate if increasing the supply of NR--a natural nicotinamide adenine dinucleotide (NAD+) precursor--could efficiently increases NAD+ levels in mammalian cells and tissues, increase SIRT1 and SIRT3 activities, prevent the detrimental metabolic effects of high-fat feeding, and enhances mitochondrial function and endurance performance. The researchers succeeded in showing that NR was capable of all of these functions, culminating in enhanced oxidative metabolism and protection against high-fat diet-induced metabolic abnormalities.

Mice on a high-fat diet fed NR over a ten-week period gained significantly less weight (60%) than mice eating the same diet, but without NR supplementation. In addition, none of the NR-treated mice had indications that they were developing diabetes, unlike the untreated mice. The mice fed NR supplements also had better endurance performance and improved energy expenditure compared to those who had not received the vitamins; and no side effects were evident in mice given the NR supplement. The study was published on June 6, 2012, in Cell Metabolism.

“The results indicate that the natural vitamin NR could be used as a nutritional supplement to ameliorate metabolic and age-related disorders characterized by defective mitochondrial function,” concluded lead author Carles Canto, PHD, of the EPFL. “Cells use what they need when they need it, and the rest is set aside without being transformed into any kind of deleterious form.”

The researchers believe that the increase in the NR molecule leads to an improvement in mitochondrial function, which is also believed to play a role in the aging process, and hypothesize that by stimulating mitochondrial with the NR molecule, longevity, as well as other health aspects, will also be improved.

Related Links:

Federal Polytechnic School of Lausanne



comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: This novel, flexible film that can react to light is a promising step toward an artificial retina (Photo courtesy of the American Chemical Society).

Novel Nanofilm May Be Artificial Retina Precursor

Researchers have used advanced nanotechnology techniques to develop a light-sensitive film that has potential for future artificial retina applications. Investigators at the Hebrew University of Jerusalem... Read more

Drug Discovery

view channel
Image: Disruption and removal of malaria parasites by the experimental drug (+)-SJ733 (Photo courtesy of the University of California, San Francisco).

Experimental Antimalaria Drug Induces the Immune System to Destroy Infected Red Blood Cells

An experimental drug for the treatment of malaria was found to induce morphological changes in infected erythrocytes that enabled the immune system to recognize and eliminate them. Investigators at... Read more

Biochemistry

view channel

Blocking Enzyme Switch Turns Off Tumor Growth in T-Cell Acute Lymphoblastic Leukemia

Researchers recently reported that blocking the action of an enzyme “switch” needed to activate tumor growth is emerging as a practical strategy for treating T-cell acute lymphoblastic leukemia. An estimated 25% of the 500 US adolescents and young adults diagnosed yearly with this aggressive disease fail to respond to... Read more

Business

view channel

R&D Partnership Initiated to Reduce Development Time for New Drugs

nanoPET Pharma, GmbH (Berlin, Germany) signed an open-ended framework contract with the international pharmaceutical company Boehringer Ingelheim (Ridgefield, CT, USA). By developing customized contrast agents for research in both basic and preclinical studies, nanoPET Pharma will contribute to the enhancement of Boehringer... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.