Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING
GLOBETECH PUBLISHING
JIB

Is Capsaicin the Future of Weight Loss?

By BiotechDaily International staff writers
Posted on 28 May 2012
A new study claims that vagal de-afferentation using capsaicin, the component responsible for the burning sensation of chili peppers, can achieve weight loss, and reduce the risk of obesity-related diseases with fewer side effects when compared to bariatric surgical options.

Researchers at Brigham and Women's Hospital (BWH; Boston, MA, USA) wished to test the impact of disrupting vagal signaling by selective vagal de-afferentation using capsaicin on weight gain and fat content in diet-induced obese male Sprague–Dawley rats; the animals were maintained for 11 months on a high-caloric Western diet. Abdominal visceral fat content was assessed by magnetic resonance imaging (MRI) together with weight of fat pads at harvest. Glucose homeostasis was assessed by fasting blood glucose and HbA1C. Jejunal SGLT1 gene expression was assessed by qPCR and immune blotting, and function by glucose uptake in everted jejunal sleeves.

The results showed that at 11-months, the de-afferented rats weighed 7% less than the sham procedure cohort, and more importantly, they also had an 18% reduction in visceral abdominal fat. There were no changes in blood glucose or glycemic indexes. SGLT1 mRNA, protein, and function were unchanged across all cohorts at 11-months postoperatively. The study was published in the May 2012 issue of Digestive Diseases and Sciences.

“The reduction in visceral fat is particularly important. High visceral fat volume is a marker of obesity and obesity-related diseases, such as diabetes. Preferentially lost visceral fat after vagal de-afferentation highlights the potential for this procedure,” said lead author Ali Tavakkolizadeh, MD, of the BWH department of surgery.

Vagotomy is a surgical procedure that involves removing the vagus nerve, which sends information between the gut and the brain. Vagal de-afferentation also involves the vagus nerve, but rather than removing the nerve completely, capsaicin is used to destroy only the nerve fibers that transport signals from the gut to the brain, leaving intact the nerve fibers that send signals in the opposite direction, from the brain to the gut.

Related Links:

Brigham and Women's Hospital




comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: This micrograph depicts the presence of aerobic Gram-negative Neisseria meningitidis diplococcal bacteria; magnification 1150x (Photo courtesy of the CDC - US Centers for Disease Control and Prevention).

Infection by Meningitis Bacteria Depends on Dimerization State of Certain Host Cell Proteins

A team of molecular microbiologists has untangled the complex three-way interaction between the non-integrin laminin receptor (LAMR1), galectin-3 (Gal-2), and the pathogenic bacterium Neisseria meningitidis.... Read more

Drug Discovery

view channel

Molecule in Green Tea Used as Carrier for Anticancer Proteins

A molecule that is a key ingredient in green tea can be employed as a carrier for anticancer proteins, forming a stable and effective therapeutic nanocomplex. This new discovery could help to construct better drug-delivery systems. Some cancer treatments depend on medication comprising the therapeutic drug and a carrier... Read more

Lab Technologies

view channel
Image: Yale West Campus is organized into research institutes and core facilities — all designed to promote collaboration and interdisciplinary dialogue (Photo courtesy of Yale University).

American and European Partners Establish a Microscopy Center of Excellence

A prominent American university has announced a partnership agreement with a major European producer of microscopes and imaging tools that will establish a center for the use of cutting-edge imaging technologies... Read more

Business

view channel

Interest in Commercial Applications for Proteomics Continues to Grow

Increasing interest in the field of proteomics has led to a series of agreements between private proteomic companies and academic institutions as well as deals between pharmaceutical companies and novel proteomics innovator biotech companies. Proteomics is the study of the structure and function of proteins.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.