Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC
GLOBETECH MEDIA

Is Capsaicin the Future of Weight Loss?

By BiotechDaily International staff writers
Posted on 28 May 2012
A new study claims that vagal de-afferentation using capsaicin, the component responsible for the burning sensation of chili peppers, can achieve weight loss, and reduce the risk of obesity-related diseases with fewer side effects when compared to bariatric surgical options.

Researchers at Brigham and Women's Hospital (BWH; Boston, MA, USA) wished to test the impact of disrupting vagal signaling by selective vagal de-afferentation using capsaicin on weight gain and fat content in diet-induced obese male Sprague–Dawley rats; the animals were maintained for 11 months on a high-caloric Western diet. Abdominal visceral fat content was assessed by magnetic resonance imaging (MRI) together with weight of fat pads at harvest. Glucose homeostasis was assessed by fasting blood glucose and HbA1C. Jejunal SGLT1 gene expression was assessed by qPCR and immune blotting, and function by glucose uptake in everted jejunal sleeves.

The results showed that at 11-months, the de-afferented rats weighed 7% less than the sham procedure cohort, and more importantly, they also had an 18% reduction in visceral abdominal fat. There were no changes in blood glucose or glycemic indexes. SGLT1 mRNA, protein, and function were unchanged across all cohorts at 11-months postoperatively. The study was published in the May 2012 issue of Digestive Diseases and Sciences.

“The reduction in visceral fat is particularly important. High visceral fat volume is a marker of obesity and obesity-related diseases, such as diabetes. Preferentially lost visceral fat after vagal de-afferentation highlights the potential for this procedure,” said lead author Ali Tavakkolizadeh, MD, of the BWH department of surgery.

Vagotomy is a surgical procedure that involves removing the vagus nerve, which sends information between the gut and the brain. Vagal de-afferentation also involves the vagus nerve, but rather than removing the nerve completely, capsaicin is used to destroy only the nerve fibers that transport signals from the gut to the brain, leaving intact the nerve fibers that send signals in the opposite direction, from the brain to the gut.

Related Links:

Brigham and Women's Hospital




WATERS CORPORATION

Channels

Genomics/Proteomics

view channel
Image: Exosomes loaded with catalase (shown in red) efficiently interact with neurons (shown in black) to protect them from the effects of Parkinson\'s disease (Photo courtesy of Dr. Elena Batrakova, University of North Carolina).

Exome Delivery of the Anti-Oxidant Catalase Reduces Parkinson's Disease Symptoms in Mouse Model

The exosome delivery of the antioxidant enzyme catalase was shown to dramatically reduce symptoms of Parkinson's disease (PD) in a mouse model. Exosomes are cell-derived vesicles that are present in... Read more

Drug Discovery

view channel
Image: Star-like glial cells in red surround alpha-beta plaques in the cortex of a mouse with a model of Alzheimer\'s disease (Photo courtesy of Strittmatter laboratory/Yale University).

Experimental Cancer Drug Reverses Symptoms in Mouse Model of Alzheimer's Disease

An experimental, but clinically disappointing drug for treatment of cancer has been found to be extremely effective in reversing the symptoms of Alzheimer's disease (AD) in a mouse model.... Read more

Lab Technologies

view channel
Image: The gene assembly robot, the GeneTheatre (Photo courtesy of Analytik Jena AG).

Genomic Research Laboratories Await New Compact Liquid Handling System

A small footprint benchtop liquid handler that automates multiple gene assembly tasks and associated procedures such as PCR setup is now available for use by biotech and genomic research laboratories.... Read more

Business

view channel

NanoString and MD Anderson Collaborate on Development of Novel Multi-Omic Expression Profiling Assays for Cancer

The University of Texas MD Anderson Cancer Center (Houston, TX, USA) and NanoString Technologies, Inc. (Seattle, WA, USA) will partner on development of a revolutionary new type of assay—simultaneously profiling gene and protein expression, initially aiming to discover and validate biomarker signatures for immuno-oncology... Read more
 

Events

27 May 2015 - 28 May 2015
02 Jun 2015 - 03 Jun 2015
15 Jun 2015 - 18 Jun 2015
Copyright © 2000-2015 Globetech Media. All rights reserved.