Features Partner Sites Information LinkXpress
Sign In
Demo Company

Is Capsaicin the Future of Weight Loss?

By BiotechDaily International staff writers
Posted on 28 May 2012
Print article
A new study claims that vagal de-afferentation using capsaicin, the component responsible for the burning sensation of chili peppers, can achieve weight loss, and reduce the risk of obesity-related diseases with fewer side effects when compared to bariatric surgical options.

Researchers at Brigham and Women's Hospital (BWH; Boston, MA, USA) wished to test the impact of disrupting vagal signaling by selective vagal de-afferentation using capsaicin on weight gain and fat content in diet-induced obese male Sprague–Dawley rats; the animals were maintained for 11 months on a high-caloric Western diet. Abdominal visceral fat content was assessed by magnetic resonance imaging (MRI) together with weight of fat pads at harvest. Glucose homeostasis was assessed by fasting blood glucose and HbA1C. Jejunal SGLT1 gene expression was assessed by qPCR and immune blotting, and function by glucose uptake in everted jejunal sleeves.

The results showed that at 11-months, the de-afferented rats weighed 7% less than the sham procedure cohort, and more importantly, they also had an 18% reduction in visceral abdominal fat. There were no changes in blood glucose or glycemic indexes. SGLT1 mRNA, protein, and function were unchanged across all cohorts at 11-months postoperatively. The study was published in the May 2012 issue of Digestive Diseases and Sciences.

“The reduction in visceral fat is particularly important. High visceral fat volume is a marker of obesity and obesity-related diseases, such as diabetes. Preferentially lost visceral fat after vagal de-afferentation highlights the potential for this procedure,” said lead author Ali Tavakkolizadeh, MD, of the BWH department of surgery.

Vagotomy is a surgical procedure that involves removing the vagus nerve, which sends information between the gut and the brain. Vagal de-afferentation also involves the vagus nerve, but rather than removing the nerve completely, capsaicin is used to destroy only the nerve fibers that transport signals from the gut to the brain, leaving intact the nerve fibers that send signals in the opposite direction, from the brain to the gut.

Related Links:

Brigham and Women's Hospital

Print article



view channel
Image: Glioblastoma multiforme (GBM) (Photo courtesy of the University of California, San Diego School of Medicine).

How Blocking TROY Signaling Slows Brain Cancer Growth

Cancer researchers have found how the low molecular weight drug propentofylline (PPF) slows the growth of the aggressive brain tumor glioblastoma multiforme (GBM). This form of brain cancer is the most... Read more

Lab Technologies

view channel
Image: The new ambr 15 fermentation micro-bioreactor system was designed to enhance microbial strain screening applications (Photo courtesy of Sartorius Stedim Biotech).

New Bioreactor System Streamlines Strain Screening and Culture

Biotechnology laboratories working with bacterial cultures will benefit from a new automated micro bioreactor system that was designed to enhance microbial strain screening processes. The Sartorius... Read more


view channel

Purchase of Biopharmaceutical Company Will Boost Development of Nitroxyl-Based Cardiovascular Disease Drugs

A major international biopharmaceutical company has announced the acquisition of a private biotech company that specializes in the development of drugs for treatment of cardiovascular disease. Bristol-Myers Squibb Co. (New York, NY, USA) has initiated the process to buy Cardioxyl Pharmaceuticals Inc. (Chapel Hill, NC, USA).... Read more
Copyright © 2000-2015 Globetech Media. All rights reserved.