Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH MEDIA
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC

Grape Seed Compound Slows Progression of Alzheimer’s Disease in Mouse Model

By BiotechDaily International staff writers
Posted on 15 May 2012
A team of neurobiologists has identified the specific polyphenolic compound responsible for improved cognitive function in a mouse model of Alzheimer's disease (AD).

Investigators at Mount Sinai School of Medicine (New York, NY, USA) had previously shown that compounds present in grape seed polyphenolic extract (GSPE) protected against the development of Alzheimer’s disease by blocking the formation of toxic amyloid-beta (A-beta) oligomers in brain tissue.

In the current study, which was published in the April 11, 2012, issue of the Journal of Neuroscience, they revealed new information relating to the bioavailability, metabolism, and bioactivity of this compound, especially in the brain.

They reported that GSPE is comprised of the proanthocyanidin (PAC) catechin and epicatechin in monomeric (Mo), oligomeric, and polymeric forms. Following oral administration of the independent GSPE forms, only Mo was able to improve cognitive function and only Mo metabolites could selectively reach and accumulate in the brain. Furthermore, they showed that a biosynthetic epicatechin metabolite, 3′-O-methyl-epicatechin-5-O-beta-glucuronide (3′-O-Me-EC-Gluc), one of the PAC metabolites identified in the brain following Mo treatment, promoted basal synaptic transmission and long-term potentiation at physiologically relevant concentrations in hippocampus slices through mechanisms associated with cAMP response element binding protein (CREB) signaling. This activity benefited cognition by improving synaptic plasticity in the brain.

“My team, along with many members of the scientific community, did not know how we could harness the efficacy of naturally occurring polyphenols in food for treatment of Alzheimer’s disease,” said senior author Dr. Giulio Maria Pasinetti, professor of neurology at Mount Sinai School of Medicine. “We were skeptical that these naturally occurring polyphenols would reach the brain because they are extensively metabolized following ingestion. While this is an exciting development, we have a lot to discover and many years of testing before this agent can be considered in humans. I look forward to further studying this compound to determine its feasibility as a treatment for Alzheimer’s disease.”

Related Links:

Mount Sinai School of Medicine




Channels

Drug Discovery

view channel
Image: Wafers like the one shown here are used to create “organ-on-a-chip” devices to model human tissue (Photo courtesy of Dr. Anurag Mathur, University of California, Berkeley).

Human Heart-on-a-Chip Cultures May Replace Animal Models for Drug Development and Safety Screening

Human heart cells growing in an easily monitored silicon chip culture system may one day replace animal-based model systems for drug development and safety screening. Drug discovery and development... Read more

Biochemistry

view channel
Image:  Model depiction of a novel cellular mechanism by which regulation of cryptochromes Cry1 and Cry2 enables coordination of a protective transcriptional response to DNA damage caused by genotoxic stress (Photo courtesy of the journal eLife, March 2015, Papp SJ, Huber AL, et al.).

Two Proteins Critical for Circadian Cycles Protect Cells from Mutations

Scientists have discovered that two proteins critical for maintaining healthy day-night cycles also have an unexpected role in DNA repair and protecting cells against genetic mutations that could lead... Read more

Business

view channel

Roche Acquires Signature Diagnostics to Advance Translational Research

Roche (Basel, Switzerland) will advance translational research for next generation sequencing (NGS) diagnostics by leveraging the unique expertise of Signature Diagnostics AG (Potsdam, Germany) in biobanks and development of novel NGS diagnostic assays. Signature Diagnostics is a privately held translational oncology... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.