Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Events

10 May 2016 - 16 May 2016
11 May 2016 - 13 May 2016

Omega-3 Fatty Acids of No Help Treating Multiple Sclerosis

By BiotechDaily International staff writers
Posted on 03 May 2012
Print article
A new study claims that supplementation with ω−3 fatty acids had no beneficial effects on multiple sclerosis (MS) disease activity.

Researchers at Haukeland University Hospital (Bergen, Norway), the Norwegian University of Science and Technology (NTNU; Trondheim), and other institutions conducted a randomized, double blind, placebo-controlled trial at 13 public neurology departments in Norway totaling 92 patients (ages 18 to 55) with relapsing-remitting MS. The patients were given either 1,350 mg of eicosapentaenoic acid (EPA) and 850 mg docosahexaenoic acid (DHA) every day, or placebo. After the first six months of the trial, all patients were also given 44 mcg of interferon beta-1a three times a week for another 18 months.

The primary outcome measure was magnetic resonance imaging (MRI) disease activity, as measured by the number of new enhancing lesions during the first six months. Secondary outcome measures included MRI disease activity after 9 and 24 months, relapse rate, disability progression, fatigue, quality of life, and safety.

The results showed that the cumulative number of MRI lesions during the first six months were similar in the ω−3 fatty acids and placebo groups. No difference in relapse rate was detected after six or 24 months; the proportion of patients without disability progression was 70% in both groups. No differences were detected in fatigue or quality-of-life scores, and no safety concerns appeared. Serum analyses of fatty acids showed an increase in ω−3 fatty in the patients treated with ω−3 fatty acids compared with the placebo group. The researchers found that the lesion rate ratio was significantly lower only after interferon treatment. The study was published ahead of print on April 16, 2012, in the Archives of Neurology.

“Omega-3 fatty acids have no beneficial effects on disease activity in MS, either as monotherapy or in combination with interferon beta-1a,” concluded lead author Oivind Torkildsen, MD, PhD, and colleagues of the Norwegian Multiple Sclerosis Competence Center. “As expected, the MRI disease activity was significantly reduced when interferon beta-1a was introduced.”

MS is an inflammatory disease in which the fatty myelin sheaths around the axons of the brain and spinal cord are damaged, leading to demyelination and scarring, as well as a broad spectrum of signs and symptoms resulting from the inability of nerve cells in the brain and spinal cord to communicate with each other effectively. Disease onset usually occurs in young adults, and it is more common in women.

Related Links:

Haukeland University Hospital
Norwegian University of Science and Technology




Print article

Channels

Genomics/Proteomics

view channel
Image: An artistic rendering of the Zika virus structure (Photo courtesy of Dr. Guntur Fibriansah, Duke-NUS Medical School).

High Resolution Structure of Zika virus Expected to Aid Vaccine Development

A team of molecular virologists used advanced cryo-electron microscopy techniques to establish a high-resolution structure for the Zika virus, a formerly neglected pathogen that has recently been associated... Read more

Drug Discovery

view channel

Experimental Small-Molecule Anticancer Drug Blocks RAS-binding Domains

The experimental small-molecule anticancer drug rigosertib was shown to block tumor growth by acting as an RAS-mimetic and interacting with the RAS binding domains of RAF kinases, resulting in their inability to bind to RAS, which inhibited the RAS-RAF-MEK pathway. Oncogenic activation of RAS genes due to point mutations... Read more

Biochemistry

view channel
Image: A space-filling model of the anticonvulsant drug carbamazepine (Photo courtesy of Wikimedia Commons).

Wastewater May Contaminate Crops with Potentially Dangerous Pharmaceuticals

Reclaimed wastewater used to irrigate crops is contaminated with pharmaceutical residues that can be detected in the urine of those who consumed such produce. Investigators at the Hebrew University... Read more

Lab Technologies

view channel

Huge Modifiable Biomedical Database to Be Available on the Wikidata Site

Genome researchers are exploiting the power of the open Internet community Wikipedia database to create a comprehensive resource for geneticists, molecular biologists, and other interested life scientists. While efficiency in generating scientific data improves almost daily, applying meaningful relationships between... Read more

Business

view channel

European Biotech Agreement to Promote Antigen-Drug Conjugation Technology

Two European biotech companies have joined forces to exploit and commercialize an innovative, site-specific ADC (antigen-drug conjugate) conjugation technology. ProBioGen (Berlin, Germany), a company specializing in the development and manufacture of complex glycoproteins and Eucodis Bioscience (Vienna, Austria), a... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.