Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC
PZ HTL SA

Oncolytic Viruses Shown to Target and Kill Pancreatic Cancer Stem Cells

By BiotechDaily International staff writers
Posted on 25 May 2011
Oncolytic viruses quickly infect and kill cancer stem cells, which may provide a treatment for tumors that are resistant to conventional chemotherapy and radiation, particularly pancreatic cancer, according to new research. The findings are particularly significant since pancreatic cancer has a poor prognosis and is difficult to detect and treat at early stages.

Investigators led by Joyce Wong, MD, a surgical researcher with Memorial Sloan-Kettering Cancer Center (New York, NY, USA), examined whether they could use oncolytic viruses, which are naturally occurring viruses that have been genetically engineered to be safe and express tracking genes, as a possible therapy against pancreatic cancer stem cells. These stem cells are thought to cause disease recurrence and metastasis, even after therapy, and oncolytic viruses may offer a new treatment strategy.

"What we learned is that oncolytic viruses have been engineered to selectively target cancer cells and have a low toxicity profile in animal studies," said Dr. Wong. "Targeting the cancer stem cell may enhance our ability to eradicate tumors and prevent future recurrence of disease."

While much research has been performed on isolating the cancer stem cell from various hematologic cancers, this research was based on the presence or absence of specific cell surface markers. Numerous mechanisms of how these cancer stem cells resist chemotherapy and radiation have also been examined. However, up to now, there has not been any research assessing whether genetically modified viruses can target and kill pancreatic cancer stem cells.

Investigators tried to determine whether the viruses containing a marker gene that expresses green fluorescent protein could infect pancreatic cancer stem cells and ultimately kill the cancer stem cell. Their findings were promising and validated that viral activity was correlated with green fluorescent protein expression.

Dr. Wong added that future studies are needed to determine whether oncolytic virus administration in vivo will help eradicate tumors and prevent future disease recurrence, and that while these initial findings are encouraging, further study is necessary to see whether oncolytic viruses will be clinically beneficial as a therapy.

Dr. Wong presented the study's findings at Digestive Disease Week 2011 (DDW) May 9, 2011, in Chicago (IL, USA). DDW is the largest international gathering of physicians, researchers, and academics in the fields of gastroenterology, hepatology, endoscopy, and gastrointestinal surgery.

Related Links:

Memorial Sloan-Kettering Cancer Center




SLAS - Society for Laboratory Automation and Screening
RANDOX LABORATORIES
BIOSIGMA S.R.L.
comments powered by Disqus

Channels

Genomics/Proteomics

view channel

MicroRNA Panel Identifies Mild Brain Trauma in a Mouse Model

A study conducted on a mouse model found that a panel of 13 serum microRNAs (miRNAs) could be used to identify the severity of damage to the brain and the risk of developing adverse effects following mild traumatic brain injury (mTBI). MTBI is a heterogeneous injury that may lead to the development of neurological and... Read more

Drug Discovery

view channel

Omega 3 Found to Improve Behavior in Children with ADHD

Supplements of the fatty acids omega 3 and 6 can help children and adolescents who have a specific kind of have attention deficit hyperactivity disorder (ADHD). Moreover, these findings indicate that a customized cognitive training program can improve problem behavior in children with ADHD. Statistics show that 3%–6%... Read more

Biochemistry

view channel

Blocking Enzyme Switch Turns Off Tumor Growth in T-Cell Acute Lymphoblastic Leukemia

Researchers recently reported that blocking the action of an enzyme “switch” needed to activate tumor growth is emerging as a practical strategy for treating T-cell acute lymphoblastic leukemia. An estimated 25% of the 500 US adolescents and young adults diagnosed yearly with this aggressive disease fail to respond to... Read more

Lab Technologies

view channel
Image: Mouse kidneys, liver, and pancreas imaged after treatment with a variety of protocols: a saline solution, Scale, SeeDB (see deep brain), CUBIC, and carotid body (CB) perfusion (which was used in this study) (Photo courtesy of RIKEN Quantitative Biology Center).

Nearly Transparent Mice Offers Potential of Whole-Organism Imaging

Japanese researchers have developed a method that combines tissue decolorization and light-sheet fluorescent microscopy to take extremely detailed images of the interior of individual organs and even entire... Read more

Business

view channel

Two Industry Partnerships Initiated to Fuel Neuroscience Research

Faster, more complex neural research is now attainable by combining technology from two research companies. Blackrock Microsystems, LLC (Salt Lake City, UT, USA), a developer of neuroscience research equipment, announced partnerships with two neuroscience research firms—PhenoSys, GmbH (Berlin, Germany) and NAN Instruments, Ltd.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.