Features | Partner Sites | Information | LinkXpress
Sign In
PZ HTL SA
GLOBETECH PUBLISHING
GLOBETECH PUBLISHING

Indian Spice Ingredient Kills Cancer Cells

By BiotechDaily International staff writers
Posted on 10 Nov 2009
A new study has revealed that curcumin, a compound found in the spice Turmeric, kills esophageal cancer cells in the laboratory via an unforeseen cell-death mechanism.

Researchers at University College Cork (UCC, Ireland) found that curcumin treatment of an esophageal cancer cell line reduced the viability of all cells within 24 hours of treatment. Since the common path of cell death is apoptosis--a cell suicide path triggered by proteins called caspases--the researchers added a molecule that stops the caspases triggering apoptosis, and found that it made no difference to the number of cells that died. The curcumin seems to induce cell death by a mechanism that was not reliant on apoptosis induction, and in fact, the cells began to digest themselves. The study was published in the October 28, 2009, issue of the British Journal of Cancer.

"The incidence of esophageal cancer has gone up by more than a half since the 70's, particularly in the Western world, and this is thought to be linked to rising rates of obesity, alcohol intake and reflux disease, so finding ways to both treat and prevent this disease is extremely important,” said study coauthor Professor Gerald O'Sullivan, M.D., Ph.D., who heads the Cork Cancer Research Center (CCRC) at UCC. "The development of natural compounds as chemo-preventative agents is also a very promising area of research.”

Curcumin is the principal curcuminoid of the ginger family (Zingiberaceae); the other two curcuminoids are desmethoxycurcumin and bis-desmethoxycurcumin. The curcuminoids are polyphenols and thus responsible for the yellow color of turmeric, which has been used historically as a component of Indian Ayurvedic medicine since 1900 BCE to treat a wide variety of ailments. A recent study on curcumin effects on cancer stated that curcumin modulates growth of tumor cells through regulation of multiple cell signaling pathways, including the cell proliferation pathway, cell survival pathway, caspase activation pathway, tumor suppressor pathway, death receptor pathway, mitochondrial pathways, and the protein kinase pathway.

Related Links:

University College Cork



Channels

Genomics/Proteomics

view channel
Image: The TheraCyte cell encapsulation device (Photo courtesy of TheraCyte, Inc.).

Encapsulated Human-Insulin-Producing Progenitor Cells Cure Diabetes in Mouse Model

A breakthrough system that allows subcutaneous implantation of encapsulated immature pancreatic cells (beta progenitor cells) was shown to produce enough insulin to correct the symptoms of diabetes in a mouse model.... Read more

Drug Discovery

view channel
Image: Chitosan is derived from the shells of shrimp and other sea crustaceans, including Alaskan pink shrimp, pictured here (Photo courtesy of NOAA - [US] National Oceanic and Atmospheric Administration).

Chitosan Treatment Clears the Way for Antibiotics to Eliminate Recurrent Urinary Tract Infections

Recurrent urinary tract infection was successfully resolved in a mouse model by treatment with the exfoliant chitosan followed by a round of antibiotics. Bacterial urinary tract infection (UTI), most... Read more

Biochemistry

view channel

Mitochondrial Cause of Aging Can Be Reversed

Researchers have found a cause of aging in lab animals that can be reversed, possibly providing an avenue for new treatments for age-related diseases including type 2 diabetes, cancer, muscle wasting, and inflammatory diseases. The researchers plan to begin human trials late 2014. The study, which was published December... Read more

Therapeutics

view channel

Cytokine Identified That Causes Mucositis in Cancer Therapy Patients

The action of the cytokine interleukin 1-beta (IL-1beta) has been found to underlie the onset of mucositis, a common, severe side effect of chemotherapy and irradiation of cancer patients. Mucositis occurs as a result of cell death in reaction to chemo- or radiotherapy. The mucosal lining of the mouth becomes thin, may... Read more

Business

view channel

Analytical Sciences Trade Fair Declared a Rousing Success

Organizers of this year's 24th "analytica" biosciences trade fair have reported significant increases in both the number of visitors and exhibitors compared to the 2012 event. The analytica trade fair for laboratory technology, analysis, and biotechnology has been held at the Munich (Germany) Trade Fair Center every... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.