We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
INTEGRA BIOSCIENCES AG

Download Mobile App




Review Focuses on Lipid Nanoparticles as Gene Therapy Carriers

By LabMedica International staff writers
Posted on 01 Mar 2017
Print article
Image: A micrograph showing lipid nanoparticles (Photo courtesy of the University of the Basque Country).
Image: A micrograph showing lipid nanoparticles (Photo courtesy of the University of the Basque Country).
A recent review article focused on the potential of solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) for gene therapy, including the main advances in their application for the treatment of ocular diseases, infectious diseases, lysosomal storage disorders, and cancer and current research for their future clinical application.

The review was written by investigators in the PharmaNanoGene: a pharmacokinetics, nanotechnology, and gene therapy research group at the University of the Basque Country. This team has been working on the design and evaluation of SLNs for treatment of diseases using gene therapy. They have been studying the relationship between formulation factors and the processes involving the intracellular internalization and disposition of the genetic material that condition the effectiveness of the vectors and which is essential in the optimization process.

The investigators wrote in the December 2016 issue of the European Journal of Pharmaceutics and Biopharmaceutics that non-viral vectors, including SLNs and NLCs, were less effective than viral vectors but much safer, and that their effectiveness has increased significantly in recent years. Lipid nanoparticles are able to overcome the main biological barriers for cell transfection, including degradation by nucleases, cell internalization intracellular trafficking, and selectively targeting to a specific cell type. They stressed that these nanoparticles were made up of biocompatible, biodegradable materials, that they were easy to produce on a large scale, that they could be sterilized and freeze-dried, and that they were very stable both in biological fluids and in storage.

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Specimen Collection & Transport
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
Gold Member
Real-time PCR System
GentierX3 Series

Print article

Channels

Clinical Chemistry

view channel
Image: Reaching speeds up to 6,000 RPM, this centrifuge forms the basis for a new type of inexpensive, POC biomedical test (Photo courtesy of Duke University)

POC Biomedical Test Spins Water Droplet Using Sound Waves for Cancer Detection

Exosomes, tiny cellular bioparticles carrying a specific set of proteins, lipids, and genetic materials, play a crucial role in cell communication and hold promise for non-invasive diagnostics.... Read more

Molecular Diagnostics

view channel
Image: MOF materials efficiently enrich cfDNA and cfRNA in blood through simple operational process (Photo courtesy of Science China Press)

Blood Circulating Nucleic Acid Enrichment Technique Enables Non-Invasive Liver Cancer Diagnosis

The ability to diagnose diseases early can significantly enhance the effectiveness of clinical treatments and improve survival rates. One promising approach for non-invasive early diagnosis is the use... Read more

Hematology

view channel
Image: The low-cost portable device rapidly identifies chemotherapy patients at risk of sepsis (Photo courtesy of 52North Health)

POC Finger-Prick Blood Test Determines Risk of Neutropenic Sepsis in Patients Undergoing Chemotherapy

Neutropenia, a decrease in neutrophils (a type of white blood cell crucial for fighting infections), is a frequent side effect of certain cancer treatments. This condition elevates the risk of infections,... Read more

Pathology

view channel
Image: The OvaCis Rapid Test discriminates benign from malignant epithelial ovarian cysts (Photo courtesy of INEX)

Intra-Operative POC Device Distinguishes Between Benign and Malignant Ovarian Cysts within 15 Minutes

Ovarian cysts represent a significant health issue for women globally, with up to 10% experiencing this condition at some point in their lives. These cysts form when fluid collects within a thin membrane... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.