Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Events

06 Jun 2016 - 09 Jun 2016
22 Jun 2016 - 24 Jun 2016
04 Jul 2016 - 06 Jul 2016

X-Ray Imaging System Enables Scientists to See in Real Time How Effective Treatments are for Cystic Fibrosis

By BiotechDaily International staff writers
Posted on 25 Aug 2014
Print article
Image: Dr. Kaye Morgan, Monash University (Photo courtesy of Monash University).
Image: Dr. Kaye Morgan, Monash University (Photo courtesy of Monash University).
A new imaging approach allows researchers to monitor the effectiveness of a treatment for the life-threatening genetic disorder.

Cystic fibrosis affects many of the body’s systems, but most severely the lungs, and currently it can take several months to measure how effective treatment is for the early-fatal lung disease.

Dr. Kaye Morgan, from Monash University (Melbourne; VIC, Australia), and lead researcher of the study, reported that the new X-ray imaging strategy allows researchers to visualize soft tissue structures, for example, the airways, brain, and lungs, which are effectively hidden in standard X-ray images. “At the moment we typically need to wait for a cystic fibrosis treatment to have an effect on lung health, measured by either a lung CT [computed tomography] scan or breath measurement, to see how effective that treatment is,” Dr. Morgan said. “However the new imaging technique allows us for the first time to noninvasively see how the treatment is working ‘live’ on the airway surface.”

Dr. Morgan noted that this X-ray imaging method would enable clinicians and researchers to measure how effective treatments are, and progress new treatments to the clinic at a much quicker rate, a key goal of the investigators. “Because we will be able to see how effectively treatments are working straight away, we’ll be able to develop new treatments a lot more quickly, and help better treat people with cystic fibrosis,” Dr. Morgan said.

Dr. Morgan noted that the new imaging technology, which was developed using a synchrotron X-ray source, may also create new avenues for assessing how effective treatments were for other lung, heart, and brain diseases.

The study’s findings were published August 15, 2014, in the American Journal of Respiratory and Critical Care Medicine.

Related Links:

Monash University



Print article

Channels

Genomics/Proteomics

view channel
Image: Follicular helper T-cells (TFH cells, shown in blue) play a crucial role in the maturation of antibody-producing B-cells (shown in green). Activated B-cells give rise germinal centers (shown in red), where mature B-cells proliferate and produce highly specific antibodies against pathogens. Top left: normal germinal center in a mouse tonsil. All others: Germinal centers fail to form when the interaction between ICOS and TBK1 is interrupted (Photo courtesy of Dr. Kok-Fai Kong, La Jolla Institute for Allergy and Immunology).

Molecular Pathway Controlling High-affinity Antibody Production Identified

A molecular pathway has been identified that controls formation of follicular helper T-cells (TFH cells) germinal centers and production of high-affinity antibodies through interaction with the inducible... Read more

Drug Discovery

view channel

Experimental Small-Molecule Anticancer Drug Blocks RAS-binding Domains

The experimental small-molecule anticancer drug rigosertib was shown to block tumor growth by acting as an RAS-mimetic and interacting with the RAS binding domains of RAF kinases, resulting in their inability to bind to RAS, which inhibited the RAS-RAF-MEK pathway. Oncogenic activation of RAS genes due to point mutations... Read more

Biochemistry

view channel
Image: A space-filling model of the anticonvulsant drug carbamazepine (Photo courtesy of Wikimedia Commons).

Wastewater May Contaminate Crops with Potentially Dangerous Pharmaceuticals

Reclaimed wastewater used to irrigate crops is contaminated with pharmaceutical residues that can be detected in the urine of those who consumed such produce. Investigators at the Hebrew University... Read more

Lab Technologies

view channel

Huge Modifiable Biomedical Database to Be Available on the Wikidata Site

Genome researchers are exploiting the power of the open Internet community Wikipedia database to create a comprehensive resource for geneticists, molecular biologists, and other interested life scientists. While efficiency in generating scientific data improves almost daily, applying meaningful relationships between... Read more

Business

view channel

European Biotech Agreement to Promote Antigen-Drug Conjugation Technology

Two European biotech companies have joined forces to exploit and commercialize an innovative, site-specific ADC (antigen-drug conjugate) conjugation technology. ProBioGen (Berlin, Germany), a company specializing in the development and manufacture of complex glycoproteins and Eucodis Bioscience (Vienna, Austria), a... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.