Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC
PZ HTL SA

Mass Spectrometry Technology Maps Chemicals as They Migrate Into Skin

By BiotechDaily International staff writers
Posted on 14 May 2014
A mass spectrometry technique gaining acceptance for medical applications such as imaging tumor surfaces can also be used to analyze the migration of small-molecule compounds applied to the skin. Because skin is such a complicated organ, the technology could be a helpful for developing transdermal drugs.

The study’s findings were published April 28, 2014, in the Journal of the American Chemical Society. Stanford University (Stanford, CA, USA) chemistry Profs. Richard N. Zare and Justin Du Bois, postdoc Livia S. Eberlin, graduate student John V. Mulcahy, and colleagues revealed that desorption electrospray ionization-mass spectrometry (DESI-MS) imaging has many advantages over other approaches that require complicated preparation of skin samples.

Moreover, DESI-MS imaging can be performed under ambient settings, instead of in a vacuum condition, as other MS methods require. Furthermore, test compounds do not have to be radioactively labeled or tagged with unwieldy dye molecules that could affect the compounds’ normal migration through skin. “That’s why this method is very appealing,” said Mark R. Prausnitz, a chemical and biomolecular engineering professor who heads the Laboratory for Drug Delivery at Georgia Institute of Technology (Atlanta, GA, USA).

DESI-MS was developed 10 years ago and involves spraying charged solvent droplets at a surface. Backsplash droplets containing dissolved molecules are then captured and examined using a mass spectrometer. The technology has been used for medical applications such as imaging drugs in tissue samples.

The Stanford scientists chose a number of small molecules that change sodium channels in skin cells, including lidocaine and a shellfish toxin. They applied them to the surface of skin samples and were able to track the compounds’ migration to a depth of 1.2 mm.

Such studies of drug migration are required to enlarge the limited selection of transdermal drugs, according to Prof. Prausnitz. Only approximately 30 agents, such as nicotine, have transdermal versions. The drugs must be small, lipophilic, and effective at a low dose. With this newly adapted tool, however, scientists could more readily study methods to enhance skin permeation, Prof. Prausnitz reported. “We’re very interested in the pathway--which part of the skin did the drug go through?”

Related Links:

Stanford University



RANDOX LABORATORIES
SLAS - Society for Laboratory Automation and Screening
BIOSIGMA S.R.L.
comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: The Human Protein Atlas is tissue-based map of the human proteome (Photo courtesy of the Human Protein Atlas).

Open Source Tissue-Based Map of the Human Proteome Launched

Constructed with 13 million annotated images, an interactive database has been created to show the distribution of proteins in all major tissues and organs of the human body. Ten years after the completion... Read more

Drug Discovery

view channel

Omega 3 Found to Improve Behavior in Children with ADHD

Supplements of the fatty acids omega 3 and 6 can help children and adolescents who have a specific kind of have attention deficit hyperactivity disorder (ADHD). Moreover, these findings indicate that a customized cognitive training program can improve problem behavior in children with ADHD. Statistics show that 3%–6%... Read more

Biochemistry

view channel

Blocking Enzyme Switch Turns Off Tumor Growth in T-Cell Acute Lymphoblastic Leukemia

Researchers recently reported that blocking the action of an enzyme “switch” needed to activate tumor growth is emerging as a practical strategy for treating T-cell acute lymphoblastic leukemia. An estimated 25% of the 500 US adolescents and young adults diagnosed yearly with this aggressive disease fail to respond to... Read more

Business

view channel

Two Industry Partnerships Initiated to Fuel Neuroscience Research

Faster, more complex neural research is now attainable by combining technology from two research companies. Blackrock Microsystems, LLC (Salt Lake City, UT, USA), a developer of neuroscience research equipment, announced partnerships with two neuroscience research firms—PhenoSys, GmbH (Berlin, Germany) and NAN Instruments, Ltd.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.