Features | Partner Sites | Information | LinkXpress
Sign In
PZ HTL SA
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC

Tissue-Penetrating Light Releases Chemotherapy inside Cancer Cells

By BiotechDaily International staff writers
Posted on 02 Mar 2014
Researchers have developed an advanced way of using light to convey chemotherapy safely to cancer cells. A light-activated drug delivery system is particularly promising, because it can accomplish spatial and temporal control of drug release.

Drs. Jeffrey Zink, professor of chemistry and biochemistry, and Fuyu Tamanoi, professor of microbiology, immunology, and molecular genetics, and colleagues, from the University of California, Los Angeles’ (UCLA) Jonsson Comprehensive Cancer Center (JCCC; Los Angeles, USA) published their findings February 20, 2014, in the journal Small.

Finding ways to deliver and release anticancer drugs in a controlled way that only targets the tumor can greatly decrease the amount of side effects from treatment, and greatly increase the cancer-killing efficacy of the drugs. The challenges of treating cancer frequently comes from the difficulty of getting anticancer chemotherapy drugs to tumor cells without damaging healthy tissue in the process. Many cancer patients experience treatment side effects that are the result of drug exposure to healthy tissues.

A major challenge in the development of light-activated drug delivery is to design a system that can respond to tissue-penetrating light. Drs. Tamanoi and Zink joined their diverse teams and collaborated with Dr. Jean-Olivier Durand at University of Montpellier, France to develop a new type of microscopic particles (nanoparticles) that can absorb energy from tissue-penetrating light that releases pharmaceutical agents in cancer cells.

These new nanoparticles are armed with specially designed nanovalves that can control release of anticancer drugs from thousands of pores, or tiny tubes, which hold molecules of chemotherapy drugs within them. The ends of the pores are blocked with capping molecules that hold the drug in similar to a cork in a bottle. The nanovalves contain special molecules that respond to the energy from two-photon light exposure, which opens the pores and releases the anticancer drugs. The performance of the nanoparticles was demonstrated in the laboratory using human breast cancer cells.

Because the effective depth range of the two-photon laser in the infrared red wavelength can reach 4 cm from the skin surface, this delivery system is best suited for tumors that can be reached within that range, which possibly include stomach breast, colon, and ovarian cancers.

Another facet of the nanoparticles is that they are fluorescent and therefore can be monitored in the body with molecular imaging techniques. This allows the researchers to track the progress of the nanoparticle into the cancer cell to safeguard that it is in its target before light activation. This ability to track a targeted therapy to its target has been called “theranostics” in the scientific nomenclature. “We have a wonderful collaboration,” said Dr. Zink. “When the JCCC brings together totally diverse fields, in this case a physical chemist and a cell signaling scientist, we can do things that neither one could do alone.”

“Our collaboration with scientists at Charles Gerhardt Institute was important to the success of this two-photon activated technique,” said Dr. Tamanoi. “It provides controls over drug delivery to allow local treatment that dramatically reduces side effects.”

Related Links:

University of California, Los Angeles’ Jonsson Comprehensive Cancer Center




comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: This novel, flexible film that can react to light is a promising step toward an artificial retina (Photo courtesy of the American Chemical Society).

Novel Nanofilm May Be Artificial Retina Precursor

Researchers have used advanced nanotechnology techniques to develop a light-sensitive film that has potential for future artificial retina applications. Investigators at the Hebrew University of Jerusalem... Read more

Drug Discovery

view channel
Image: Disruption and removal of malaria parasites by the experimental drug (+)-SJ733 (Photo courtesy of the University of California, San Francisco).

Experimental Antimalaria Drug Induces the Immune System to Destroy Infected Red Blood Cells

An experimental drug for the treatment of malaria was found to induce morphological changes in infected erythrocytes that enabled the immune system to recognize and eliminate them. Investigators at... Read more

Biochemistry

view channel

Blocking Enzyme Switch Turns Off Tumor Growth in T-Cell Acute Lymphoblastic Leukemia

Researchers recently reported that blocking the action of an enzyme “switch” needed to activate tumor growth is emerging as a practical strategy for treating T-cell acute lymphoblastic leukemia. An estimated 25% of the 500 US adolescents and young adults diagnosed yearly with this aggressive disease fail to respond to... Read more

Business

view channel

R&D Partnership Initiated to Reduce Development Time for New Drugs

nanoPET Pharma, GmbH (Berlin, Germany) signed an open-ended framework contract with the international pharmaceutical company Boehringer Ingelheim (Ridgefield, CT, USA). By developing customized contrast agents for research in both basic and preclinical studies, nanoPET Pharma will contribute to the enhancement of Boehringer... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.